Disease penetrance and risk stratification for sudden cardiac death in asymptomatic hypertrophic cardiomyopathy mutation carriers

Eur Heart J. 2009 Nov;30(21):2593-8. doi: 10.1093/eurheartj/ehp306. Epub 2009 Aug 6.

Abstract

Aims: To investigate the outcome of cardiac evaluation and the risk stratification for sudden cardiac death (SCD) in asymptomatic hypertrophic cardiomyopathy (HCM) mutation carriers.

Methods and results: Seventy-six HCM mutation carriers from 32 families identified by predictive DNA testing underwent cardiac evaluation including history, examination, electrocardiography, Doppler echocardiography, exercise testing, and 24 h Holter monitoring. The published diagnostic criteria for HCM in adult members of affected families were used to diagnose HCM. Thirty-three (43%) men and 43 (57%) women with a mean age of 42 years (range 16-79) were examined; in 31 (41%) HCM was diagnosed. Disease penetrance was age related and men were more often affected than women (P = 0.04). Myosin Binding Protein C (MYBPC3) mutation carriers were affected at higher age than Myosin Heavy Chain (MYH7) mutation carriers (P = 0.01). Risk factors for SCD were present in affected and unaffected carriers.

Conclusion: Hypertrophic cardiomyopathy was diagnosed in 41% of carriers. Disease penetrance was age dependent, warranting repeated cardiologic evaluation. The MYBPC3 mutation carriers were affected at higher age than MYH7 mutation carriers. Risk factors for SCD were present in carriers with and without HCM. Follow-up studies are necessary to evaluate the effectiveness of risk stratification for SCD in this population.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Cardiac Myosins / genetics
  • Cardiomyopathy, Hypertrophic / genetics*
  • Carrier Proteins / genetics
  • Death, Sudden, Cardiac / etiology*
  • Female
  • Genetic Testing
  • Heterozygote*
  • Humans
  • Male
  • Middle Aged
  • Mutation / genetics*
  • Myosin Heavy Chains / genetics
  • Pedigree
  • Penetrance*
  • Risk Assessment
  • Young Adult

Substances

  • Carrier Proteins
  • MYH7 protein, human
  • myosin-binding protein C
  • Cardiac Myosins
  • Myosin Heavy Chains