Accumulation and toxicity of intravenously-injected functionalized graphene oxide in mice
Kai-Ping Wen
National Tsing Hua University, Department of Materials Science and Engineering, Hsinchu City, Taiwan, 30013
Search for more papers by this authorCorresponding Author
Ying-Chieh Chen
National Hsinchu University of Education, Department of Applied Science, Hsinchu City, Taiwan, 30014
Correspondence to: Ying-Chieh Chen, National Hsinchu University of Education, Department of Applied Science, Hsinchu City, Taiwan 30014.
E-mail: [email protected]
Nyan-Hwa Tai, National Tsing Hua University, Department of Materials Science and Engineering, Hsinchu City, Taiwan 30013.
E-mail: [email protected]
Search for more papers by this authorChia-Hui Chuang
National Hsinchu University of Education, Department of Applied Science, Hsinchu City, Taiwan, 30014
Search for more papers by this authorHwan-You Chang
National Tsing Hua University, Department of Life Science, Hsinchu City, Taiwan, 30013
Search for more papers by this authorChi-Young Lee
National Tsing Hua University, Department of Materials Science and Engineering, Hsinchu City, Taiwan, 30013
Search for more papers by this authorCorresponding Author
Nyan-Hwa Tai
National Tsing Hua University, Department of Materials Science and Engineering, Hsinchu City, Taiwan, 30013
Correspondence to: Ying-Chieh Chen, National Hsinchu University of Education, Department of Applied Science, Hsinchu City, Taiwan 30014.
E-mail: [email protected]
Nyan-Hwa Tai, National Tsing Hua University, Department of Materials Science and Engineering, Hsinchu City, Taiwan 30013.
E-mail: [email protected]
Search for more papers by this authorKai-Ping Wen
National Tsing Hua University, Department of Materials Science and Engineering, Hsinchu City, Taiwan, 30013
Search for more papers by this authorCorresponding Author
Ying-Chieh Chen
National Hsinchu University of Education, Department of Applied Science, Hsinchu City, Taiwan, 30014
Correspondence to: Ying-Chieh Chen, National Hsinchu University of Education, Department of Applied Science, Hsinchu City, Taiwan 30014.
E-mail: [email protected]
Nyan-Hwa Tai, National Tsing Hua University, Department of Materials Science and Engineering, Hsinchu City, Taiwan 30013.
E-mail: [email protected]
Search for more papers by this authorChia-Hui Chuang
National Hsinchu University of Education, Department of Applied Science, Hsinchu City, Taiwan, 30014
Search for more papers by this authorHwan-You Chang
National Tsing Hua University, Department of Life Science, Hsinchu City, Taiwan, 30013
Search for more papers by this authorChi-Young Lee
National Tsing Hua University, Department of Materials Science and Engineering, Hsinchu City, Taiwan, 30013
Search for more papers by this authorCorresponding Author
Nyan-Hwa Tai
National Tsing Hua University, Department of Materials Science and Engineering, Hsinchu City, Taiwan, 30013
Correspondence to: Ying-Chieh Chen, National Hsinchu University of Education, Department of Applied Science, Hsinchu City, Taiwan 30014.
E-mail: [email protected]
Nyan-Hwa Tai, National Tsing Hua University, Department of Materials Science and Engineering, Hsinchu City, Taiwan 30013.
E-mail: [email protected]
Search for more papers by this authorAbstract
Graphene and its functionalized derivatives have recently emerged as interesting nanomaterials with promising applications in biomedicine. In this study, the long-term in vivo biodistribution of intravenously injected nanographene oxide (NGO) functionalized with poly sodium 4-styrenesulfonate (PSS) was systematically examined and the potential toxicity over 6 months of NGO-PSS nanoparticles was investigated. Our results showed that the nanoparticles mainly accumulate in the lung, liver and spleen, where they persist for at least 6 months. These nanoparticles result in acute liver injury and chronic inflammation of the lung, liver and spleen, as evidenced by blood biochemistry results and histological examinations. Copyright © 2015 John Wiley & Sons, Ltd.
Supporting Information
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