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Aptamer/Graphene Oxide Nanocomplex for in Situ Molecular Probing in Living Cells

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Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing 100084, People’s Republic of China, and Pacific Northwest National Laboratory, Richland, Washington 99352
[email protected]; [email protected]
†Tsinghua University.
‡Pacific Northwest National Laboratory.
Cite this: J. Am. Chem. Soc. 2010, 132, 27, 9274–9276
Publication Date (Web):June 21, 2010
https://doi.org/10.1021/ja103169v
Copyright © 2010 American Chemical Society
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    Abstract

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    Graphene has shown fascinating applications in bionanotechnology, including DNA sensing, protein assays, and drug delivery. However, exploration of graphene with intracellular monitoring and in situ molecular probing is still at an early stage. In this regard, we have designed an aptamer-carboxyfluorescein (FAM)/graphene oxide nanosheet (GO-nS) nanocomplex to investigate its ability for molecular probing in living cells. Results demonstrate that uptake of aptamer-FAM/GO-nS nanocomplex and cellular target monitoring were realized successfully. The dramatic delivery, protection, and sensing capabilities of GO-nS in living cells indicate that graphene oxide could be a robust candidate for many biological fields, such as DNA and protein analysis, gene and drug delivering, and intracellular tracking.

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