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Inhibitory Effects of Viburnum dilatatum Thunb. (Gamazumi) on Oxidation and Hyperglycemia in Rats with Streptozotocin-Induced Diabetes

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Division of Environmental Technology, Aomori Industrial Research Center, 4-11-6, Daini-tonyamachi, Aomori 030-0113, Japan; Onodera Brewhouse Company, 46 Yokamachi, Sannohe town, Aomori 039-0132, Japan; and Aomori University of Health and Welfare, 58-1 Mase, Hamadate, Aomori 030-8505, Japan
Cite this: J. Agric. Food Chem. 2004, 52, 4, 1002–1007
Publication Date (Web):January 29, 2004
https://doi.org/10.1021/jf0302557
Copyright © 2004 American Chemical Society
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    Abstract

    The fruit of Viburnum dilatatum Thunb. (gamazumi) was found in a previous study to have strong radical scavenging activity. The present study investigated the antioxidative functions of gamazumi crude extract (GCE) in rats having diabetes induced by the administration of streptozotocin. In rats given water (H2O group), plasma levels of glucose, total cholesterol, and lipid peroxide (TBARS) and erythrocyte levels of TBARS increased with time over the experimental period of 10 weeks. These increases were inhibited in rats given GCE (GCE group). After 10 weeks, hepatic, renal, and pancreatic TBARS in the GCE group were significantly lower than those in the H2O group. GCE contains a high concentration of polyphenols, and it is expected that they are the active components. These results demonstrate that GCE has an inhibitory effect on the oxidative stress induced by diabetes and suggest that GCE may be useful for the prevention of diabetic complications. Furthermore, as the increase of plasma glucose and total cholesterol was inhibited in the GCE group, GCE may also have anti-hyperglycemic activity in diabetes.

    Keywords: Viburnum dilatatum (gamazumi); diabetes; lipid peroxidation; antioxidation; hyperglycemia; streptozotocin

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    *

     Author to whom correspondence should be addressed (telephone +81-17-739-9676; fax +81-17-739-9613; e-mail [email protected]).

    †

     Aomori Industrial Research Center.

    ‡

     Onodera Brewhouse Co.

    #

     Aomori University of Health and Welfare.

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    20. >Mehmet Levent Altun, Gülçin Saltan Çitoğlu, Betül Sever Yilmaz, Tülay Çoban. Antioxidant properties of Viburnum opulus and Viburnum lantana growing in Turkey. International Journal of Food Sciences and Nutrition 2008, 59 (3) , 175-180. https://doi.org/10.1080/09637480701381648
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    22. Syng-Ook Lee, Shin-Kyo Chung, Io-Seon Lee. The Antidiabetic Effect of Dietary Persimmon (Diospyros kaki L. cv. Sangjudungsi) Peel in Streptozotocin-induced Diabetic Rats. Journal of Food Science 2006, 71 (3) , S293-S298. https://doi.org/10.1111/j.1365-2621.2006.tb15656.x
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