This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
Insights into the structural and functional analysis of impact of the missense mutations on α-synuclein: an in silico study
Egyptian Journal of Medical Human Genetics Open Access 14 May 2024
Whole-genome resequencing of Chinese indigenous sheep provides insight into the genetic basis underlying climate adaptation
Genetics Selection Evolution Open Access 02 April 2024
Explicable prioritization of genetic variants by integration of rule-based and machine learning algorithms for diagnosis of rare Mendelian disorders
Human Genomics Open Access 21 March 2024
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Ramensky, V., Bork, P. & Sunyaev, S. Nucleic Acids Res. 30, 3894–3900 (2002).
Schmidt, S. et al. PLoS Genet. 4, e1000281 (2008).
Capriotti, E., Calabrese, R. & Casadio, R. Bioinformatics 22, 2729–2734 (2006).
Ng, P.C. & Henikoff, S. Nucleic Acids Res. 31, 3812–3814 (2003).
Bromberg, Y., Yachdav, G. & Rost, B. Bioinformatics 24, 2397–2398 (2008).
Yue, P., Melamud, E. & Moult, J. BMC Bioinformatics 7, 166 (2006).
Acknowledgements
We thank Y. Bromberg for help with the SNAP analysis. V.E.R. acknowledges support by the Russian Academy of Sciences Program in Molecular and Cellular Biology. This work was supported by the US National Institutes of Health (R01 GM078598 and in part by R01 MH084676).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Supplementary information
Supplementary Text and Figures
Supplementary Figures 1–4, Supplementary Tables 1–2, Supplementary Methods (PDF 646 kb)
Supplementary Software
PolyPhen-2 standalone software for Linux/Mac OS X (ZIP 414 kb)
Rights and permissions
About this article
Cite this article
Adzhubei, I., Schmidt, S., Peshkin, L. et al. A method and server for predicting damaging missense mutations. Nat Methods 7, 248–249 (2010). https://doi.org/10.1038/nmeth0410-248
Issue Date:
DOI: https://doi.org/10.1038/nmeth0410-248
This article is cited by
Whole-genome resequencing of Chinese indigenous sheep provides insight into the genetic basis underlying climate adaptation
Genetics Selection Evolution (2024)
Advances in understanding the genetic architecture of antibody response to paratuberculosis in sheep by heritability estimate and LDLA mapping analyses and investigation of candidate regions using sequence-based data
Genetics Selection Evolution (2024)
A novel missense COL9A3 variant in a pedigree with multiple lumbar disc herniation
Journal of Orthopaedic Surgery and Research (2024)
Mitochondrial point heteroplasmy: insights from deep-sequencing of human replicate samples
BMC Genomics (2024)
Whole genome sequencing in clinical practice
BMC Medical Genomics (2024)