Issue 45, 2015
From the journal:

Nanoscale

Graphene quantum dots for the inhibition of β amyloid aggregation†

Yibiao Liu,ab   Li-Ping Xu,*ab   Wenhao Dai,ab   Haifeng Dong,ab   Yongqiang Wenab  and  Xueji Zhang*ab  

* Corresponding authors

a Research Center for Bioengineering and Sensing Technology, University of Science & Technology Beijing, Beijing 100083, P.R. China
E-mail: xuliping@ustb.edu.cn, zhangxueji@ustb.edu.cn
Fax: +86-10-82375840
Tel: +86-10-82375840

b School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, P.R. China

Abstract

The aggregation of Aβ peptides is a crucial factor leading to Alzheimer's disease (AD). Inhibiting the Aβ peptide aggregation has become one of the most essential strategies to treat AD. In this work, efficient and low-cytotoxicity inhibitors, graphene quantum dots (GQDs) are reported for their application in inhibiting the aggregation of Aβ peptides. Compared to other carbon materials, the low cytotoxicity and great biocompatibility of GQDs give an advantage to the clinical research for AD. In addition, the GQDs may cross the blood–brain barrier (BBB) because of the small size. It is believed that GQDs may be therapeutic agents against AD. This work provides a novel insight into the development of Alzheimer's drugs.

Graphical abstract: Graphene quantum dots for the inhibition of β amyloid aggregation

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Article information

DOI
https://doi.org/10.1039/C5NR06282A
Article type
Paper
Submitted
12 Sep 2015
Accepted
07 Oct 2015
First published
09 Oct 2015

Nanoscale, 2015,7, 19060-19065

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Graphene quantum dots for the inhibition of β amyloid aggregation

Y. Liu, L. Xu, W. Dai, H. Dong, Y. Wen and X. Zhang, Nanoscale, 2015, 7, 19060 DOI: 10.1039/C5NR06282A

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