European Journal of Clinical Investigation

Volume 31, Issue 10 p. 836-842

ACE and angiotensinogen gene genotypes and left ventricular mass in athletes

F. Diet,

F. Diet

Universität zu Köln,

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C. Graf,

C. Graf

Institut für Kreislaufforschung und Sportmedizin, Deutsche Sporthochschule, Köln,

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N. Mahnke,

N. Mahnke

Universität zu Köln,

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G. Wassmer,

G. Wassmer

Universität zu Köln,

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H. G. Predel,

H. G. Predel

Institut für Kreislaufforschung und Sportmedizin, Deutsche Sporthochschule, Köln,

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I. Palma-Hohmann,

I. Palma-Hohmann

Institut für Kreislaufforschung und Sportmedizin, Deutsche Sporthochschule, Köln,

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R. Rost,

R. Rost

Institut für Kreislaufforschung und Sportmedizin, Deutsche Sporthochschule, Köln,

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M. Böhm,

M. Böhm

Innere Medizin III, Universitätskliniken des Saarlandes, Homburg/Saar, Germany

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F. Diet,

F. Diet

Universität zu Köln,

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C. Graf,

C. Graf

Institut für Kreislaufforschung und Sportmedizin, Deutsche Sporthochschule, Köln,

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N. Mahnke,

N. Mahnke

Universität zu Köln,

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G. Wassmer,

G. Wassmer

Universität zu Köln,

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H. G. Predel,

H. G. Predel

Institut für Kreislaufforschung und Sportmedizin, Deutsche Sporthochschule, Köln,

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I. Palma-Hohmann,

I. Palma-Hohmann

Institut für Kreislaufforschung und Sportmedizin, Deutsche Sporthochschule, Köln,

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R. Rost,

R. Rost

Institut für Kreislaufforschung und Sportmedizin, Deutsche Sporthochschule, Köln,

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M. Böhm,

M. Böhm

Innere Medizin III, Universitätskliniken des Saarlandes, Homburg/Saar, Germany

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First published: 07 July 2008

https://doi.org/10.1046/j.1365-2362.2001.00886.x

Citations: 34

Klinik III für Innere Medizin (F. Diet, N. Mahnke), and Institut für Medizinische Statistik Informatik und Epidemiologie (G. Wassmer), Universität zu Köln, Joseph-Stelzmann-Strasse 9, 50924 Köln, Germany; Institut für Kreislaufforschung und Sportmedizin, Deutsche Sporthochschule, 50927 Köln, Germany (C. Graf, H. G. Predel, I. Palma-Hohmann, R. Rost); Innere Medizin III, Universitätskliniken des Saarlandes, 66421 Homburg/Saar, Germany (M. Böhm).Correspondence to: Frank Diet MD, Klinik III für Innere Medizin, Joseph-Stelzmann-Strasse 9, 50924 Köln, Germany. Tel.: + 49–221–478 4414; fax: + 49–221–478 3137; e-mail: [email protected]

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Abstract

Background Genetic factors may be important in modifying heart size due to long-term athletic training. The significance of polymorphisms of genes of the renin–angiotensin system in myocardial mass in a population of athletes participating in different disciplines is not known.

Methods The angiotensin I-converting enzyme gene insertion/deletion (I/D) polymorphism, angiotensinogen gene M235T polymorphism and angiotensin II type 1 receptor gene A1166C polymorphism were determined in 83 male Caucasian endurance athletes and associated with left ventricular mass.

Results No association with left ventricular mass was found for the polymorphisms of angiotensin I-converting enzyme gene I/D, angiotensinogen gene M235T and angiotensin II type 1 gene A1166C when studied separately. However, combined analysis of the angiotensin I-converting enzyme gene I/D polymorphism and angiotensinogen gene M235T polymorphism genotypes suggested an association with left ventricular mass (g m⁻²) (P = 0·023). Athletes with the angiotensin I-converting enzyme gene DD/angiotensinogen gene TT genotype combination had greater left ventricular mass compared with all other genotype combinations (179·8 ± 26·1 g m⁻² vs. 145·2 ± 27·3 g m⁻², P = 0·003).

Conclusions These results suggest an association of combined angiotensin I-converting enzyme gene I/D polymorphism genotypes, and angiotensinogen gene M235T polymorphism genotypes with left ventricular hypertrophy due to long-term athletic training. A synergistic effect of angiotensin I-converting enzyme gene DD genotype and angiotensinogen gene TT genotype on left ventricular mass in endurance athletes appears to occur.

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Volume31, Issue10

October 2001

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ACE and angiotensinogen gene genotypes and left ventricular mass in athletes

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