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Hypertrophic Cardiomyopathy and Left Ventricular Non-Compaction

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Sport-related sudden cardiac death

Abstract

Hypertrophic cardiomyopathy (HCM) is a genetic myocardial disease leading to left ventricular (LV) hypertrophy (exceeding 15 mm). HCM is one of the causes of exercise-related sudden death/cardiac arrest (SD/CA) in competitive athletes. In the United States, it is the most frequent cause of SD in athletes. However, not all individuals with HCM are vulnerable to fatal arrhythmias during exercise. Therefore, a systematic approach for risk stratification is required when assessing an individual with HCM who requests exercise advice. In particular, a baseline evaluation should include a comprehensive personal and family history with consideration of the age of the individual and years of exercise prior to diagnosis, assessment of the phenotype severity, and the presence of any conventional risk factors for SD/CA. It is indisputable, however, that absence of all major risk factors does not convey immunity to SD, and even patients with low risk may die suddenly.

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Cavigli, L., D’Ascenzi, F., Pelliccia, A., Cecchi, F. (2022). Hypertrophic Cardiomyopathy and Left Ventricular Non-Compaction. In: Delise, P., Zeppilli, P. (eds) Sport-related sudden cardiac death. Springer, Cham. https://doi.org/10.1007/978-3-030-80447-3_4

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  • DOI: https://doi.org/10.1007/978-3-030-80447-3_4

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