Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiovascular disease, affecting 0.2% of the general US population. While individuals with HCM overall have less physical disability than individuals suffering from other severe cardiac illnesses, they often suffer from more psychiatric disability. Much has been written about the medical management of symptoms and complications of HCM, but there has been limited investigation of the psychologic and social issues inherent to HCM. Overall, studies have reported that patients with HCM have more psychologic distress, increased anxiety and depression, and an impaired quality of life compared to the general population. Specifically, studies have shown that mood disorders in HCM patients were significantly associated with chest pain, older age, higher perceived risk of death, poorer social adjustment, and problems with sexual relations. Those at risk for anxiety disorders included individuals who were divorced or widowed, more likely to suffer chest pain, more likely to perceive themselves to be at higher risk of death, and to have more recent diagnoses. There is a need for further research in many different psychosocial issues of HCM such as determining whether there is an association between psychologic co-morbidities and cardiovascular prognosis in patients; the prevalence and risk factors for PTSD; and which psychologic interventions best alleviate patient and family distress.