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Effectiveness of Periodic Treatment of Quercetin against Influenza A Virus H1N1 through Modulation of Protein Expression

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† Department of Food Science and Technology, BK21 Plus Program, and Foodborne Virus Research Center, Chonnam National University, Gwangju 61186, South Korea
‡ Bioenergy Research Center, Chonnam National University, Gwangju 61186, South Korea
∥ Hygienic Safety and Analysis Center, World Institute of Kimchi, Gwangju 61755, South Korea
⊥ Division of Applied Bioscience and Biotechnology, Institute of Environmentally-Friendly Agriculture, Chonnam National University, Gwangju 61186, South Korea
# Korea Basic Science Institute, Daejeon 34133, South Korea
*Department of Food Science and Technology and Foodborne Virus Research Centre, Chonnam National University, Gwangju 61186, South Korea; Tel.: 82-62-530-2144, Fax: 82-62-530-2149, E-mail: [email protected]
*Biological Disaster Analysis Group, Korea Basic Science Institute, Daejeon 34133, South Korea. Tel: 82-42-865-3446. Fax: 82-42-865-3419. E-mail: [email protected]
Cite this: J. Agric. Food Chem. 2016, 64, 21, 4416–4425
Publication Date (Web):May 9, 2016
https://doi.org/10.1021/acs.jafc.6b00148
Copyright © 2016 American Chemical Society
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    Abstract

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    Kimchi, a traditional fermented food regularly consumed in Korea, contains various types of antimicrobial compounds. Among the tested compounds present in common spices used in Kimchi, quercetin showed the highest selectivity index against influenza A virus (IAV) H1N1. In this study, the effect of pretreatment and periodic treatment with quercetin against IAV in Madin–Darby canine kidney cells was observed. Compared to pretreatment, periodic treatment resulted in significantly higher cell viability but lower relative expression of the IAV PA gene and total apoptosis and cell death. To explain the mechanisms underlying the antiviral effects of quercetin treatment, a comparative proteomic analysis was performed in four samples (mock, quercetin-treated, IAV-infected, and quercetin-treated IAV-infected). Among the 220 proteins, 56 proteins were classified nonhierarchically into three clusters and were differentially modulated by quercetin treatment in IAV-infected cells. Post-translational modifications were identified in 68 proteins. In conclusion, periodic treatment with quercetin is effective in reducing IAV infection, and differentially regulates the expression of key proteins, including heat shock proteins, fibronectin 1, and prohibitin to reduce IAV replication.

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.jafc.6b00148.

    • Identified proteins, peptide counts, and relative fold change in expression and post-translational modification of proteins, normalized abundance, and mean relative change (PDF)

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