The Cancer Spectrum Theory.
Lee HY, Song M, Stopsack KH, Peng C, Phipps AI, Wang M, Ogino S, Sasamoto N, Ugai T.
Cancer Discov. 2024 Apr 04. 14(4):589-593. PMID: 38571425
Other Positions
Instructor in Pathology
Pathology-Brigham and Women's Hospital
Harvard Medical School
Links
Overview
Dr. Ugai is a junior faculty member at Brigham and Women's Hospital/Harvard Medical School and an MD/PhD physician scientist with expertise in pathology, clinical oncology, cancer epidemiology, and molecular epidemiology. His current research focuses on early-onset cancers and tumor biomarkers, including immune and microbial characteristics of cancer. Dr. Ugai is a founder of the International Cancer Spectrum Consortium, which is an interdisciplinary working group with faculty, postdocs, and students from various institutions all over the world. Dr. Ugai's group aims to build up a resource that integrates lifestyles and biomarkers including genetics and tissue molecular markers to (a) develop effective prevention and early-detection strategies, and (b) identify novel biomarkers to guide early-stage clinical decisions.
AACR Scholar-in-Training Award for AACR Annual Meeting 2023
American Association for Cancer Research
Brigham and Women's Hospital Faculty Career Development Award
Brigham and Women's Hospital
MPE Rising Faculty Investigator Award
The 6th International MPE Meeting
Rose Traveling Fellowship Program in Chronic Disease Epidemiology and Biostatistics
Harvard Th. Chan School of Public Health
AACR Scholar-in-Training Award for AACR Special Conference: Colorectal Cancer
American Association for Cancer Research
Harvey V. Fineberg Fellowship in Cancer Prevention
Harvard Th. Chan School of Public Health
AACR Scholar-in-Training Award for AACR Annual Meeting 2022
American Association for Cancer Research
Japanese Cancer Association Young Investigator Award
Japanese Cancer Association
Bibliography
Alcohol and colorectal cancer risk subclassified by mutational signatures of DNA mismatch repair deficiency.
Fang A, Ugai T, Gurjao C, Zhong R, Liu Z, Zhang X, Wang P, Nowak J, Wang M, Giannakis M, Ogino S, Zhang X, Giovannucci E.
J Natl Cancer Inst. 2024 Apr 04. PMID: 38574386
Epidemiologic Factors in Relation to Colorectal Cancer Risk and Survival by Genotoxic Colibactin Mutational Signature.
Thomas CE, Georgeson P, Qu C, Steinfelder RS, Buchanan DD, Song M, Harrison TA, Um CY, Hullar MA, Jenkins MA, Van Guelpen B, Lynch BM, Melaku YA, Huyghe JR, Aglago EK, Berndt SI, Boardman LA, Campbell PT, Cao Y, Chan AT, Drew DA, Figueiredo JC, French AJ, Giannakis M, Goode EL, Gruber SB, Gsur A, Gunter MJ, Hoffmeister M, Hsu L, Huang WY, Moreno V, Murphy N, Newcomb PA, Newton CC, Nowak JA, Obón-Santacana M, Ogino S, Sun W, Toland AE, Trinh QM, Ugai T, Zaidi SH, Peters U, Phipps AI.
Cancer Epidemiol Biomarkers Prev. 2024 Apr 03. 33(4):534-546. PMID: 38252034
Metabolomic signatures of inflammation and metabolic dysregulation in relation to colorectal cancer risk.
Bever AM, Hang D, Lee DH, Tabung FK, Ugai T, Ogino S, Meyerhardt JA, Chan AT, Eliassen AH, Liang L, Stampfer MJ, Song M.
J Natl Cancer Inst. 2024 Mar 01. PMID: 38430005
Body size and risk of colorectal cancer molecular defined subtypes and pathways: Mendelian randomization analyses.
Papadimitriou N, Qu C, Harrison TA, Bever AM, Martin RM, Tsilidis KK, Newcomb PA, Thibodeau SN, Newton CC, Um CY, Obón-Santacana M, Moreno V, Brenner H, Mandic M, Chang-Claude J, Hoffmeister M, Pellatt AJ, Schoen RE, Harlid S, Ogino S, Ugai T, Buchanan DD, Lynch BM, Gruber SB, Cao Y, Hsu L, Huyghe JR, Lin Y, Steinfelder RS, Sun W, Van Guelpen B, Zaidi SH, Toland AE, Berndt SI, Huang WY, Aglago EK, Drew DA, French AJ, Georgeson P, Giannakis M, Hullar M, Nowak JA, Thomas CE, Le Marchand L, Cheng I, Gallinger S, Jenkins MA, Gunter MJ, Campbell PT, Peters U, Song M, Phipps AI, Murphy N.
EBioMedicine. 2024 Mar. 101:105010. PMID: 38350331
Genotoxic colibactin mutational signature in colorectal cancer is associated with clinicopathological features, specific genomic alterations and better survival.
Georgeson P, Steinfelder RS, Harrison TA, Pope BJ, Zaidi SH, Qu C, Lin Y, Joo JE, Mahmood K, Clendenning M, Walker R, Aglago EK, Berndt SI, Brenner H, Campbell PT, Cao Y, Chan AT, Chang-Claude J, Dimou N, Doheny KF, Drew DA, Figueiredo JC, French AJ, Gallinger S, Giannakis M, Giles GG, Goode EL, Gruber SB, Gsur A, Gunter MJ, Harlid S, Hoffmeister M, Hsu L, Huang WY, Huyghe JR, Manson JE, Moreno V, Murphy N, Nassir R, Newton CC, Nowak JA, Obón-Santacana M, Ogino S, Pai RK, Papadimitrou N, Potter JD, Schoen RE, Song M, Sun W, Toland AE, Trinh QM, Tsilidis K, Ugai T, Um CY, Macrae FA, Rosty C, Hudson TJ, Winship IM, Phipps AI, Jenkins MA, Peters U, Buchanan DD.
medRxiv. 2024 Jan 30. PMID: 37090539
The microbiome and rise of early-onset cancers: knowledge gaps and research opportunities.
Mima K, Hamada T, Inamura K, Baba H, Ugai T, Ogino S.
Gut Microbes. 2023 12. 15(2):2269623. PMID: 37902043
Vitamin C intake and colorectal cancer survival according to KRAS and BRAF mutation: a prospective study in two US cohorts.
Shi S, Wang K, Ugai T, Giannakis M, Cazaubiel J, Chan AT, Giovannucci EL, Nowak JA, Meyerhardt JA, Ogino S, Song M.
Br J Cancer. 2023 11. 129(11):1793-1800. PMID: 37775523
Mumps vaccine hesitancy: Current evidence and an evidence-based campaign in Japan.
Ugai S, Ugai T, Kanayama T, Kamiya H, Saitoh A, Slopen N.
Vaccine. 2023 09 22. 41(41):6036-6041. PMID: 37640569
Inverse relationship between Fusobacterium nucleatum amount and tumor CD274 (PD-L1) expression in colorectal carcinoma.
Ugai T, Shimizu T, Kawamura H, Ugai S, Takashima Y, Usui G, Väyrynen JP, Okadome K, Haruki K, Akimoto N, Masugi Y, da Silva A, Mima K, Zhang X, Chan AT, Wang M, Garrett WS, Freeman GJ, Meyerhardt JA, Nowak JA, Song M, Giannakis M, Ogino S.
Clin Transl Immunology. 2023. 12(8):e1453. PMID: 37538192
News
Lifestyle changes may be driving higher cancer rates in people under 50
Cancers are on the rise among people younger than 50, and experts think that lifestyle changes may have something to do with it—although data is not firm.
Cancer rising in people under 50
Incidence of early onset cancers—including breast, colon, esophagus, kidney, liver, and pancreas—has been dramatically increasing around the world since 1990.
