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Once again, Pfizer will have to fend off claims by New York University that the drug maker owes “hundreds of millions of dollars” in royalties on a best-selling lung cancer treatment.

A New York state appeals court on Tuesday revived a four-year-old lawsuit in which the university maintains that Pfizer breached a long-standing contract and should pay 2.5 percent royalties on Xalkori, which racked up $561 million in sales last year. The New York State Supreme Court had dismissed the suit two years ago.

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The medication was developed in 1996 by an NYU professor, Dr. Joseph Schlessinger, who later formed a company called Sugen, which struck a research and licensing deal with the school. However, Sugen was later purchased by Pharmacia, which Pfizer acquired in 2003.

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