Sulfur revisited

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Abstract

Sulfur is a time-honored therapeutic agent useful in a variety of dermatologie disorders. Its keratolytic action is due to formation of hydrogen sulfide through a reaction that depends upon direct interaction between sulfur particles and keratinocytes. The smaller the partiele size, the greater the degree of such interaction and the greater the therapeutic efficacy. When applied topically, sulfur induces various histologie changes, including hyperkeratosis, acanthosis, and dilatation of dermal vasculature. One study showed that sulfur was comedogenic when applied onto human and rabbit skin, findings that were not reproduced in other studies. About 1% of topically applied sulfur is systemically absorbed. Adverse effects from topically applied sulfur are uncommon and are mainly limited to the skin. In infants, however, fatal outcome after extensive application has been reported.

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    Supported in part by a General Clinical Research Center Grant (RR00102) from the National Institutes of Health to the Rockefeller University Hospital and with general support from the Pew Trusts.

    1

    From the Laboratory for Investigative Dermatology, The Rockefeller University.

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