Cell Reports
Volume 2, Issue 4, 25 October 2012, Pages 889-901
Article
Nucleocytoplasmic Coagulation: An Injury-Induced Aggregation Event that Disulfide Crosslinks Proteins and Facilitates Their Removal by Plasmin
Under a Creative Commons license
open access
Graphical Abstract
Highlights
► Cell death triggers the process of nucleocytoplasmic coagulation (NCC) ► NCC is the abrupt misfolding and disulfide crosslinking of intracellular proteins ► NCC-aggregated proteins facilitate plasmin formation and subsequent proteolysis ► Thus, NCC limits release and promotes proteolytic clearance of dead cell debris
Cited by (0)
Copyright © 2012 The Authors. Published by Elsevier Inc.