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Integrated Antimicrobial and Nonfouling Hydrogels to Inhibit the Growth of Planktonic Bacterial Cells and Keep the Surface Clean

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† Department of Chemical Engineering, University of Washington, Seattle, Washington 98195
*Corresponding author. E-mail: [email protected]
Cite this: Langmuir 2010, 26, 13, 10425–10428
Publication Date (Web):June 2, 2010
https://doi.org/10.1021/la101542m
Copyright © 2010 American Chemical Society
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    Abstract

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    A new strategy integrating antimicrobial and nonfouling/biocompatible properties is presented. A mild antimicrobial agent (salicylate) was incorporated into a carboxybetaine ester hydrogel, poly(N,N-dimethyl-N-(ethylcarbonylmethyl)-N-[2-(methacryloyloxy)-ethyl]ammonium salicylate) (pCBMA-1 C2 SA) hydrogel, as its anionic counterion. This new hydrogel provides a sustained release of antimicrobial agents to inhibit the growth of planktonic bacteria and create a nonfouling surface to prevent protein adsorption or bacterial accumulation upon the hydrolysis of carboxybetaine esters into zwitterionic groups. The pCBMA-1 C2 SA hydrogel inhibited the growth of both gram-negative Escherichia coli K12 and gram-positive Staphylococcus epidermidis by 99.9%. This hydrogel holds great potential in applications such as wound dressing and surface coatings for medical devices.

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    Synthesis of N,N-dimethyl-N-(ethylcarbonylmethyl)-N-[2- (methacryloyloxy)ethyl]ammonium salicylate (CBMA-1 C2 SA). In vitro salycilate release and HPLC analysis experiments. 1H NMR of CBMA-1 C2 SA at 300 MHz, D2O. In vitro SA release from pCBMA-2 hydrogels and pCBMA-1 C2 SA hydrogels as a function of time at 37 °C in water. This material is available free of charge via the Internet at http://pubs.acs.org.

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