Volume 90, Issue 2 p. 315-318
Brief Communication

Guillain–Barré Syndrome Variant Occurring after SARS-CoV-2 Vaccination

Christopher Martin Allen iBSc, MBBS, MRCP

Christopher Martin Allen iBSc, MBBS, MRCP

Department of Neurology, Nottingham University Hospitals National Health Service Trust, Nottingham, UK

School of Medicine, University of Nottingham, Nottingham, UK

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Shelby Ramsamy MBChB, MRCP

Shelby Ramsamy MBChB, MRCP

Department of Neurology, Nottingham University Hospitals National Health Service Trust, Nottingham, UK

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Alexander William Tarr BSc, PhD

Alexander William Tarr BSc, PhD

National Institute for Health Research Nottingham Biomedical Research Centre, Nottingham University Hospitals National Health Service Trust, Nottingham, UK

School of Life Sciences, University of Nottingham, Nottingham, UK

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Patrick Jason Tighe BSc, PhD

Patrick Jason Tighe BSc, PhD

National Institute for Health Research Nottingham Biomedical Research Centre, Nottingham University Hospitals National Health Service Trust, Nottingham, UK

School of Life Sciences, University of Nottingham, Nottingham, UK

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William Lucien Irving MB BChir, MA, PhD, MRCP, FRCPath

William Lucien Irving MB BChir, MA, PhD, MRCP, FRCPath

National Institute for Health Research Nottingham Biomedical Research Centre, Nottingham University Hospitals National Health Service Trust, Nottingham, UK

School of Life Sciences, University of Nottingham, Nottingham, UK

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Radu Tanasescu MD, PhD

Radu Tanasescu MD, PhD

Department of Neurology, Nottingham University Hospitals National Health Service Trust, Nottingham, UK

School of Medicine, University of Nottingham, Nottingham, UK

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Jonathan Rhys Evans MB BChir, MA, PhD, MRCP

Corresponding Author

Jonathan Rhys Evans MB BChir, MA, PhD, MRCP

Department of Neurology, Nottingham University Hospitals National Health Service Trust, Nottingham, UK

Address correspondence to Dr Evans, Department of Neurology, Queen's Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham NG7 2UH, UK. E-mail: [email protected]

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First published: 10 June 2021
Citations: 108

Abstract

Although SARS-CoV-2 vaccines are very safe, we report 4 cases of the bifacial weakness with paresthesias variant of Guillain–Barré syndrome (GBS) occurring within 3 weeks of vaccination with the Oxford–AstraZeneca SARS-CoV-2 vaccine. This rare neurological syndrome has previously been reported in association with SARS-CoV-2 infection itself. Our cases were given either intravenous immunoglobulin, oral steroids, or no treatment. We suggest vigilance for cases of bifacial weakness with paresthesias variant GBS following vaccination for SARS-CoV-2 and that postvaccination surveillance programs ensure robust data capture of this outcome, to assess for causality. ANN NEUROL 2021;90:315–318

Potential Conflicts of Interest

Nothing to report.

The full text of this article hosted at iucr.org is unavailable due to technical difficulties.

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