Equine Veterinary Journal

Volume 34, Issue 6 p. 563-571

Effect of chronic airway inflammation and exercise on pulmonary and systemic antioxidant status of healthy and heaves-affected horses

N. KIRSCHVINK,

Corresponding Author

N. KIRSCHVINK

Laboratory for Functional Investigation, Faculty of Veterinary Medicine, University of Liege, Liege, Belgium

Laboratory for Functional Investigation, Faculty of Veterinary Medicine, University of Liege, Liege, BelgiumSearch for more papers by this author

N. SMITH,

N. SMITH

Centre for Equine Studies, Animal Health Trust, Newmarket, UK

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L. FIÉVEZ,

L. FIÉVEZ

Laboratory for Functional Investigation, Faculty of Veterinary Medicine, University of Liege, Liege, Belgium

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V. BOUGNET,

V. BOUGNET

Laboratory for Functional Investigation, Faculty of Veterinary Medicine, University of Liege, Liege, Belgium

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T. ART,

T. ART

Laboratory for Functional Investigation, Faculty of Veterinary Medicine, University of Liege, Liege, Belgium

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G. DEGAND,

G. DEGAND

Laboratory for Analysis of Foodstuffs of Animal Origin, Faculty of Veterinary Medicine, University of Liege, Liege, Belgium

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D. MARLIN,

D. MARLIN

Centre for Equine Studies, Animal Health Trust, Newmarket, UK

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C. ROBERTS,

C. ROBERTS

Centre for Equine Studies, Animal Health Trust, Newmarket, UK

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B. GÉNICOT,

B. GÉNICOT

Biostatistics, Limburgs Universitair Centrum, Diepenbeek, Belgium

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P. LINDSEY,

P. LINDSEY

Biostatistics, Limburgs Universitair Centrum, Diepenbeek, Belgium

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P. LEKEUX,

P. LEKEUX

Laboratory for Functional Investigation, Faculty of Veterinary Medicine, University of Liege, Liege, Belgium

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N. KIRSCHVINK,

Corresponding Author

N. KIRSCHVINK

Laboratory for Functional Investigation, Faculty of Veterinary Medicine, University of Liege, Liege, Belgium

Laboratory for Functional Investigation, Faculty of Veterinary Medicine, University of Liege, Liege, BelgiumSearch for more papers by this author

N. SMITH,

N. SMITH

Centre for Equine Studies, Animal Health Trust, Newmarket, UK

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L. FIÉVEZ,

L. FIÉVEZ

Laboratory for Functional Investigation, Faculty of Veterinary Medicine, University of Liege, Liege, Belgium

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V. BOUGNET,

V. BOUGNET

Laboratory for Functional Investigation, Faculty of Veterinary Medicine, University of Liege, Liege, Belgium

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T. ART,

T. ART

Laboratory for Functional Investigation, Faculty of Veterinary Medicine, University of Liege, Liege, Belgium

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G. DEGAND,

G. DEGAND

Laboratory for Analysis of Foodstuffs of Animal Origin, Faculty of Veterinary Medicine, University of Liege, Liege, Belgium

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D. MARLIN,

D. MARLIN

Centre for Equine Studies, Animal Health Trust, Newmarket, UK

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C. ROBERTS,

C. ROBERTS

Centre for Equine Studies, Animal Health Trust, Newmarket, UK

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B. GÉNICOT,

B. GÉNICOT

Biostatistics, Limburgs Universitair Centrum, Diepenbeek, Belgium

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P. LINDSEY,

P. LINDSEY

Biostatistics, Limburgs Universitair Centrum, Diepenbeek, Belgium

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P. LEKEUX,

P. LEKEUX

Laboratory for Functional Investigation, Faculty of Veterinary Medicine, University of Liege, Liege, Belgium

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First published: 05 January 2010

https://doi.org/10.2746/042516402776180223

Citations: 39

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Summary

In heaves-affected horses the relation between oxidant status, airway inflammation (AI) and pulmonary function (PF) is unknown. The oxidant status of blood and pulmonary epithelial lining fluid (PELF) of healthy (H, n = 6) and heaves-affected horses in clinical remission (REM, n = 6) and in crisis (CR, n = 7) was assessed at rest, during and afterstandardised exercise test by measurement of reduced and oxidised glutathione, glutathione redox ratio [GRR%]; uric acid and 8-epi-PGF_2α. Oxidant status was related to PF parameters (mechanics of breathing and arterial blood gas tension) and AI parameters (bronchoalveolar lavage [BAL] neutrophil% and AI score). Haemolysate glutathione was significantly different between groups and was correlated with PF and AI parameters; GRR in PELF was increased during CR and was correlated with PF and AI parameters. Exercise induced an increase of plasma uric acid that was significantly higherboth in REM and CR. PELF 8-epi-PGF_2α was significantly increased in CR and correlated with PF and AI parameters. These results suggest that oxidative stress occurring in heaves is correlated with PF and AI and may be locally assessed by PELFglutathione status, uric acid and 8-epi-PGF_2α. Systemic repercussions are reflected by assay of GSH in resting horses and by uric acid in exercising horses.

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Volume34, Issue6

September 2002

Pages 563-571

Effect of chronic airway inflammation and exercise on pulmonary and systemic antioxidant status of healthy and heaves-affected horses

Summary

References

Citing Literature

References

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Effect of chronic airway inflammation and exercise on pulmonary and systemic antioxidant status of healthy and heaves-affected horses

Summary

References

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