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History of Changes in the Protocol of Clinical Trial of Zinc Supplementation in Treatment of COVID-19 by Hydroxychloroquine

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Abstract

An article published in this journal used a randomized controlled trial to evaluate the efficacy of combining chloroquine/hydroxychloroquine (CQ/HCQ) and zinc in the treatment of COVID-19 patients. Findings from this study indicate that zinc supplements did not enhance the clinical efficacy of hydroxychloroquine in improving COVID-19 treatment. Although this finding is consistent with many previous studies, several concerns regarding study protocol and trial registration, including interventions and primary outcomes, have been raised in which the protocol has been changed after the completion of the recruitment.

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References

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Author information

Authors and Affiliations

  1. Department of Social Epidemiology, Kyoto University Graduate School of Medicine, Kyoto, 6068501, Japan

    Dorn Sornsil

  2. Department of Health Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan

    Kouji H. Harada

  3. Department of Environmental Health Sciences, Faculty of Public Health, Mahidol University, Bangkok, Thailand

    Arthit Phosri

Authors
  1. Dorn Sornsil
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  2. Kouji H. Harada
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  3. Arthit Phosri
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Contributions

DS and KHH drafted the manuscript. All the authors read and approved the final manuscript.

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Correspondence to Dorn Sornsil.

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The authors declare no competing interests.

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Sornsil, D., Harada, K.H. & Phosri, A. History of Changes in the Protocol of Clinical Trial of Zinc Supplementation in Treatment of COVID-19 by Hydroxychloroquine. Biol Trace Elem Res 202, 1926–1927 (2024). https://doi.org/10.1007/s12011-023-03807-9

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  • DOI: https://doi.org/10.1007/s12011-023-03807-9

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