A War on Obesity, Not the Obese
Abstract
In their efforts to lose weight, obese individuals may be fighting a powerful set of evolutionary forces honed in an environment drastically different from that of today.
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REFERENCES AND NOTES
1
Flegal K. M., Carroll M. D., Ogden C. L., Johnson C. L., JAMA 288, 1723 (2002).
2
Editorial, New York Times, 24 November 2002.
3
Flegal K., Troiano R., Int. J. Obes. 24, 807 (2000).
4
Calle E., Thun M., Petrelli J., Rodriquez C., Heath C., N. Engl. J. Med. 341, 1097 (1999).
5
K. Flegal, personal communication.
6
Rose G., Int. J. Epidemiol. 14, 32 (1985).
7
G. Critser, Fat Land: How Americans Became the Fattest People in the World (Houghton Mifflin, Boston, 2003).
8
Allison D., et al., Int. J. Obes. 20, 501 (1996).
9
Stunkard A. J., Harris J. R., Pedersen N. L., McClearn G. E., N. Engl. J. Med. 322, 1483 (1990).
10
Murray J., J. Econ. Hist. 57, 585 (1997).
11
Montague C. T., et al., Nature 387, 903 (1997).
12
Farooqi I. S., et al., J. Clin. Invest. 110, 1093 (2002).
13
S. Farooqi, S. O'Rahilly, personal communication.
14
Yeo G., et al., Nature Genet. 20, 111 (1998).
15
Krude H., et al., Nature Genet. 19, 155 (1998).
16
Clement K., et al., Nature 392, 398 (1998).
17
Jackson R. S., et al., Nature Genet. 16, 303 (1997).
18
Spiegelman B. M., Flier J. S., Cell 104, 531 (2001).
19
Zhang Y., et al., Nature 372, 425 (1994).
20
Weigle D. S., FASEB J. 8, 302 (1994).
21
Leibel R. L., Rosenbaum M., Hirsch J., N. Eng. J. Med. 332, 621 (1995).
22
Friedman J. M., Halaas J. L., Nature 395, 763 (1998).
23
Heymsfield S., et al., JAMA 282, 1568 (1999).
24
DeFalco J., et al., Science 291, 2608 (2001).
25
Wadden T. A., et al., J. Clin. Endocrinol. Metab. 83, 214 (1998).
26
Tuomilehto J., et al., N. Engl. J. Med. 344, 1343 (2001).
27
Knowler W. C., et al., N. Engl. J. Med. 346, 393 (2002).
28
Kumanyika S., Ethn. Dis. 12, 316 (2002).
29
Dowse G., et al., Diabetes 39, 390 (1990).
30
Zimmet P., et al., Diabetes Res. 1, 13 (1984).
31
Howard B., et al., Am. J. Clin. Nutr. 53, 1577S (1991).
32
Neel J. V., Am. J. Hum. Genet. 14, 353 (1962).
33
Ravussin E., Metabolism 44, 12 (1995).
34
J. Diamond, Guns, Germs, and Steel: The Fates of Human Societies (Norton, New York, 1999).
35
Diamond J., Nature 357, 362 (1992).
36
Hawkes K., O'Connell J., Jones N., Alvarez H., Charnov E., Proc. Natl. Acad. Sci. U.S.A. 95, 1336 (1998).
37
J. Weiner, The Beak of the Finch: A Story of Evolution in Our Time (Vintage Books, New York, 1995).
38
I thank S. Korres for assistance in preparing this manuscript; M. Stoffel, J. Breslow, S. Heymesfield, P. Cohen, A. Soukas, and S. O'Rahilly for helpful comments; and K. Flegal for generously providing advice, data, and figures. Supported by NIH grant R01-DK41096.
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Science
Volume 299 | Issue 5608
7 February 2003
7 February 2003
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Published in print: 7 February 2003
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