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Earthbound and Microgravity Pathophysiology of Increased Intracranial Pressure

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Microgravity and Vision Impairments in Astronauts

Part of the book series: SpringerBriefs in Space Development ((BRIEFSSPACE))

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Abstract

Idiopathic intracranial hypertension (IIH) is a syndrome that shares many of the mechanisms observed in space. IIH is caused by an increase in cerebrospinal fluid pressure, and it is characterized by elevated intracranial pressure, although there is no neurological explanation for this. The ophthalmic changes these IIH patients are similar to those reported by astronauts.

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Notes

  1. 1.

    This is when people see flashes of light.

  2. 2.

    This is the space behind the eye.

References

  1. Corbett, JJ, Savino PJ, Thompson HS, et al. Visual loss in pseudotumor cerebri. Follow-up of 57 patients from five to 41 years and a profile of 14 patients with permanent severe visual loss. Arch Neurol. 1982;39:461–474.

    Article  CAS  PubMed  Google Scholar 

  2. Wall M, Hart WM, Jr., Burde RM. Visual field defects in idiopathic intracranial hypertension (pseudotumor cerebri) Am J Ophthalmol. 1983;96:654–669.

    Article  CAS  PubMed  Google Scholar 

  3. Wall M. Idiopathic intracranial hypertension Neurol Clin. 2010 Aug;28(3):593–617.

    Article  PubMed Central  PubMed  Google Scholar 

  4. Durcan FJ, Corbett, J. J., Wall M. The incidence of pseudotumor cerebri. Population studies in Iowa and Louisiana. Arch Neurol. 1988;45:875–877.

    Article  CAS  PubMed  Google Scholar 

  5. Radhakrishnan, K, Ahlskog JE, Cross SA, Kurland LT, O’Fallon WM. Idiopathic intracranial hypertension (pseudotumor cerebri). Descriptive epidemiology in Rochester, Minn, 1976 to 1990. Arch Neurol. 1993;50:78–80.

    Article  CAS  PubMed  Google Scholar 

  6. Giuseffi, V, Wall M, Siegel PZ, Rojas PB. Symptoms and disease associations in idiopathic intracranial hypertension (pseudotumor cerebri): a case-control study. Neurology. 1991;41:239–244.

    Article  CAS  PubMed  Google Scholar 

  7. Wall, M. The headache profile of idiopathic intracranial hypertension. Cephalagia. 1990; 10:331–335.

    Article  CAS  Google Scholar 

  8. Frisén, L. Swelling of the optic nerve head: a staging scheme. J Neurol Neurosurg Psychiatr.1982;45:13–18. Scott CJ, Kardon RH, Lee AG, Frisen L, Wall M. Diagnosis and Grading of Papilledema in Patients with Raised Intracranial Pressure Using Optical Coherence Tomography (OCT) Compared to Clinical Expert Assessment using a Clinical Staging Scale. Arch Ophthalmol. 2010.

    Google Scholar 

  9. Corbett, JJ, Jacobson DM, Mauer RC, Thompson HS. Enlargement of the blind spot caused by papilledema. Am J Ophthalmol. 1988;105:261–265.

    Article  CAS  PubMed  Google Scholar 

  10. Corbett, JJ, Thompson HS. The rational management of idiopathic intracranial hypertension. Arch Neurol. 1989;46:1049–1051.

    Google Scholar 

  11. Johnston, I, Paterson A. Benign intracranial hypertension. II. CSF pressure and circulation. Brain.1974;97:301–312.

    Article  CAS  PubMed  Google Scholar 

  12. Johnson, LN, Krohel GB, Madsen RW, March, G. A. Jr. The role of weight loss and acetazolamide in the treatment of idiopathic intracranial hypertension (pseudotumor cerebri) Ophthalmology.1998;105:2313–2317.

    Article  CAS  PubMed  Google Scholar 

  13. McCarthy, KD, Reed, D. J., The effect of acetazolamide and furosemide on CSF production and choroid plexus carbonic anhydrase activity. J Pharmacol Exp Ther. 1974;189:194–201.

    CAS  PubMed  Google Scholar 

  14. Celebisoy, N, Gokcay, F, Sirin H, Akyurekli O. Treatment of idiopathic intracranial hypertension: topiramate vs acetazolamide, an open-label study. Acta Neurol Scand. 2007;116:322–327.

    Article  CAS  PubMed  Google Scholar 

  15. Pollay, M, Fullenwider, C, Roberts, P. A., Stevens, F. A. Effect of mannitol and furosemide on blood-brain osmotic gradient and intracranial pressure. J. Neurosurg. 1983;59:945–950.

    Article  CAS  PubMed  Google Scholar 

  16. Goh, KY, Schatz, NJ, Glaser, JS. Optic nerve sheath fenestration for pseudotumor cerebri. J Neuro-Ophthalmol. 1997;17:86–91.

    Article  CAS  Google Scholar 

  17. Chandrasekaran, S, McCluskey, P, Minassian, D, Assaad, N. Visual outcomes for optic nerve sheath fenestration in pseudotumour cerebri and related conditions. Clin Experiment Ophthalmol.2006;34:661–665.

    Article  PubMed  Google Scholar 

  18. Degnan, AJ, Levy, LM. Pseudotumor cerebri: Brief review of clinical syndrome and imaging findings. Am. J. Neuroradiol. 2011, 32, 1986–1993.

    Google Scholar 

  19. Arora, A, Upreti, L, Kapoor, A, Gupta, R, Sharma, P, Puri, SK. Pseudotumor Cerebri: MR Imaging Findings; Department of Radiodiagnosis, G.B. Pant Hospital and associated Maulana Azad Medical College: New Delhi, India, 2010.

    Google Scholar 

  20. George, U, Bansal, G, Pandian, J. Magnetic resonance “flip-flop” in idiopathic intracranial hypertension. J. Neurosci. Rural Pract. 2011, 2, 84–86.

    Article  PubMed Central  PubMed  Google Scholar 

  21. Kramer, LA, Sargsyan, AE, Hasan, KM, Polk, JD, Hamilton DR. Orbital and intracranial effects of microgravity: Findings at 3-T MR imaging. Radiology 2012, 263, 819–827.

    Article  PubMed  Google Scholar 

  22. Brodsky MC, Vaphiades M. Magnetic resonance imaging in pseudotumor cerebri. Ophthalmology 1998, 105, 1686–1693.

    Article  CAS  PubMed  Google Scholar 

  23. Jonas JB, Berenshtein E, Holbach L. Anatomic relationship between lamina cribrosa, intraocular space, and cerebrospinal fluid space. Invest Ophthalmol Vis Sci. 2003 Dec;44(12):5189–95.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Manned Spaceflight Consultant, Sandefjord, Norway

    Erik Seedhouse

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  1. Erik Seedhouse
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Correspondence to Erik Seedhouse .

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Seedhouse, E. (2015). Earthbound and Microgravity Pathophysiology of Increased Intracranial Pressure. In: Microgravity and Vision Impairments in Astronauts. SpringerBriefs in Space Development. Springer, Cham. https://doi.org/10.1007/978-3-319-17870-7_3

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  • DOI: https://doi.org/10.1007/978-3-319-17870-7_3

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-17869-1

  • Online ISBN: 978-3-319-17870-7

  • eBook Packages: MedicineMedicine (R0)

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