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Space physiology VI: exercise, artificial gravity, and countermeasure development for prolonged space flight

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Abstract

When applied individually, exercise countermeasures employed to date do not fully protect the cardiovascular and musculoskeletal systems during prolonged spaceflight. Recent ground-based research suggests that it is necessary to perform exercise countermeasures within some form of artificial gravity to prevent microgravity deconditioning. In this regard, it is important to provide normal foot-ward loading and intravascular hydrostatic-pressure gradients to maintain musculoskeletal and cardiovascular function. Aerobic exercise within a centrifuge restores cardiovascular function, while aerobic exercise within lower body negative pressure restores cardiovascular function and helps protect the musculoskeletal system. Resistive exercise with vibration stimulation may increase the effectiveness of resistive exercise by preserving muscle function, allowing lower intensity exercises, and possibly reducing risk of loss of vision during prolonged spaceflight. Inexpensive methods to induce artificial gravity alone (to counteract head-ward fluid shifts) and exercise during artificial gravity (for example, by short-arm centrifuge or exercise within lower body negative pressure) should be developed further and evaluated as multi-system countermeasures.

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References

  • Akima H, Kubo K, Kanehisa H, Suzuki Y, Gunji A, Fukunaga T (2000) Leg-press resistance training during 20 days of 6 degrees head-down-tilt bed rest prevents muscle deconditioning. Eur J Appl Physiol 82:30–38

    Article  PubMed  CAS  Google Scholar 

  • Akima H, Ushiyama J, Kubo J, Tonosaki S, Itoh M, Kawakami Y, Fukuoka H, Kanehisa H, Fukunaga T (2003) Resistance training during unweighting maintains muscle size and function in human calf. Med Sci Sports Exerc 35:655–662

    Article  PubMed  Google Scholar 

  • Alkner BA, Tesch PA (2004) Efficacy of a gravity-independent resistance exercise device as a countermeasure to muscle atrophy during 29-day bed rest. Acta Physiol Scand 181:345–357

    Article  PubMed  CAS  Google Scholar 

  • Aratow M, Fortney SM, Watenpaugh DE, Crenshaw AG, Hargens AR (1993) Transcapillary fluid responses to lower body negative pressure. J Appl Physiol 74:2763–2770

    PubMed  CAS  Google Scholar 

  • Arbeille PP, Besnard SS, Kerbeci PP, Mohty DM (2005) Portal vein cross-sectional area and flow and orthostatic tolerance: a 90-day bed rest study. J Appl Physiol 99:1853–1857

    Article  PubMed  Google Scholar 

  • Arbeille P, Kerbeci P, Mattar L, Shoemaker JK, Hughson R (2008) Insufficient flow reduction during LBNP in both splanchnic and lower limb areas is associated with orthostatic intolerance after bedrest. Am J Physiol Heart Circ Physiol 295:H1846–H1854

    Article  PubMed  CAS  Google Scholar 

  • Arya M, Paloski WH, Young LR (2007) Centrifugation protocol for the NASA Artificial Gravity-Bed Rest Pilot Study. J Gravit Physiol: J Int Soc Gravit Physiol 14:P5–P8

    Google Scholar 

  • Baecker N, Tomic A, Mika C, Gotzmann A, Platen P, Gerzer R, Heer M (2003) Bone resorption is induced on the second day of bed rest: results of a controlled crossover trial. J Appl Physiol 95:977–982

    PubMed  CAS  Google Scholar 

  • Baecker N, Frings-Meuthen P, Heer M, Mester J, Liphardt AM (2012) Effects of vibration training on bone metabolism: results from a short-term bed rest study. Eur J Appl Physiol 112:1741–1750

    Article  PubMed  CAS  Google Scholar 

  • Bamman MM, Clarke MS, Feeback DL, Talmadge RJ, Stevens BR, Lieberman SA, Greenisen MC (1998) Impact of resistance exercise during bed rest on skeletal muscle sarcopenia and myosin isoform distribution. J Appl Physiol 84:157–163

    PubMed  CAS  Google Scholar 

  • Behnke BJ, Zawieja DC, Gashev AA, Ray CA, Delp MD (2008) Diminished mesenteric vaso- and venoconstriction and elevated plasma ANP and BNP with simulated microgravity. J Appl Physiol 104:1273–1280

    Article  PubMed  CAS  Google Scholar 

  • Belavy DL, Beller G, Ritter Z, Felsenberg D (2011) Bone structure and density via HR-pQCT in 60d bed-rest, 2-years recovery with and without countermeasures. J Musculoskelet Neuronal Interact 11:215–226

    PubMed  CAS  Google Scholar 

  • Belavy DL, Wilson SJ, Armbrecht G, Rittweger J, Felsenberg D, Richardson CA (2012) Resistive vibration exercise during bed-rest reduces motor control changes in the lumbo-pelvic musculature. J Electromyogr Kinesiol 22(1):21–30

    Article  PubMed  Google Scholar 

  • Bloomfield SA (2006) Does altered blood flow to bone in microgravity impact on mechanotransduction? J Musculoskelet Neuronal Interact 6:324–326

    PubMed  CAS  Google Scholar 

  • Boda WL, Watenpaugh DE, Ballard RE, Hargens AR (2000) Supine lower body negative pressure exercise simulates metabolic and kinetic features of upright exercise. J Appl Physiol 89:649–654

    PubMed  CAS  Google Scholar 

  • Booth FW, Lees SJ (2007) Fundamental questions about genes, inactivity, and chronic diseases. Physiological genomics 28:146–157

    Google Scholar 

  • Caiozzo VJ, Haddad F, Lee S, Baker M, Paloski W, Baldwin KM (2009) Artificial gravity as a countermeasure to microgravity: a pilot study examining the effects on knee extensor and plantar flexor muscle groups. J Appl Physiol 107:39–46

    Article  PubMed  CAS  Google Scholar 

  • Cao P, Kimura S, Macias BR, Ueno T, Watenpaugh DE, Hargens AR (2005) Exercise within lower body negative pressure partially counteracts lumbar spine deconditioning associated with 28-day bed rest. J Appl Physiol 99:39–44

    Article  PubMed  Google Scholar 

  • Colleran PN, Wilkerson MK, Bloomfield SA, Suva LJ, Turner RT, Delp MD (2000) Alterations in skeletal perfusion with simulated microgravity: a possible mechanism for bone remodeling. J Appl Physiol 89:1046–1054

    PubMed  CAS  Google Scholar 

  • Convertino VA (1996) Exercise and adaptation to microgravity environments. Handbook of physiology, pp 815–843

  • Demiot C, Dignat-George F, Fortrat JO, Sabatier F, Gharib C, Larina I, Gauquelin-Koch G, Hughson R, Custaud MA (2007) WISE 2005: chronic bed rest impairs microcirculatory endothelium in women. Am J Physiol Heart Circ Physiol 293:H3159–H3164

    Article  PubMed  CAS  Google Scholar 

  • Dickerman RD, Smith GH, Langham-Roof L, McConathy WJ, East JW, Smith AB (1999) Intra-ocular pressure changes during maximal isometric contraction: does this reflect intra-cranial pressure or retinal venous pressure? Neurol Res 21:243–246

    PubMed  CAS  Google Scholar 

  • Diedrich A, Paranjape SY, Robertson D (2007) Plasma and blood volume in space. Am J Med Sci 334:80–85

    Article  PubMed  Google Scholar 

  • Dorfman TA, Levine BD, Tillery T, Peshock RM, Hastings JL, Schneider SM, Macias BR, Biolo G, Hargens AR (2007) Cardiac atrophy in women following bed rest. J Appl Physiol 103:8–16

    Article  PubMed  Google Scholar 

  • Ferrando AA, Lane HW, Stuart CA, Davis-Street J, Wolfe RR (1996) Prolonged bed rest decreases skeletal muscle and whole body protein synthesis. Am J Physiol 270:E627–E633

    PubMed  CAS  Google Scholar 

  • Ferrando AA, Tipton KD, Bamman MM, Wolfe RR (1997) Resistance exercise maintains skeletal muscle protein synthesis during bed rest. J Appl Physiol 82:807–810

    PubMed  CAS  Google Scholar 

  • Fogarty JA, Otto C, Kerstman E, Oubre C, Wu J (2011) The visual impairment intracranial pressure summit Report. NASA Johnson Space Center, Houston, TX

  • Fong KJ, Arya M, Paloski WH (2007) Gender differences in cardiovascular tolerance to short radius centrifugation. J Gravit Physiol: J Int Soc Gravit Physiol 14:P15–P19

    Google Scholar 

  • Garber CE, Blissmer B, Deschenes MR, Franklin BA, Lamonte MJ, Lee IM, Nieman DC, Swain DP (2011) American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc 43:1334–1359

    Article  PubMed  Google Scholar 

  • Genc KO, Mandes VE, Cavanagh PR (2006) Gravity replacement during running in simulated microgravity. Aviat Space Environ Med 77:1117–1124

    PubMed  Google Scholar 

  • Gibson EG (1977) Skylab 4 Crew Observations. In: Johnston RS, F. DL (eds) Biomedical results from skylab (NASA SP-377), Washington D.C., pp 22–26

  • Greenleaf JE, Chou JL, Stad NJ, Leftheriotis GP, Arndt NF, Jackson CG, Simonson SR, Barnes PR (1999) Short-arm (1.9 m) +2.2 Gz acceleration: isotonic exercise load-O2 uptake relationship. Aviat Space Environ Med 70:1173–1182

    PubMed  CAS  Google Scholar 

  • Guinet P, Schneider SM, Macias BR, Watenpaugh DE, Hughson RL, Le Traon AP, Bansard JY, Hargens AR (2009) WISE-2005: effect of aerobic and resistive exercises on orthostatic tolerance during 60 days bed rest in women. Eur J Appl Physiol 106:217–227

    Article  PubMed  Google Scholar 

  • Hamilton MT, Hamilton DG, Zderic TW (2007) Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease. Diabetes 56:2655–2667

    Article  PubMed  CAS  Google Scholar 

  • Hargens AR, Cologne JB, Menninger FJ, Hogan JS, Tucker BJ, Peters RM (1981) Normal transcapillary pressures in human skeletal muscle and subcutaneous tissues. Microvasc Res 22:177–189

    Article  PubMed  CAS  Google Scholar 

  • Hargens AR, Macias B, Echon CM, Brzezinski E, Hawkins A, Hawkins K, Meyer RS (2006) Testing exercise countermeasures during 30 days of simulated microgravity: Lessons learned from studies of identical twins. Gravitational and Space Biology 19:53–64

    Google Scholar 

  • Hargens AR, Richardson S (2009) Cardiovascular adaptations, fluid shifts, and countermeasures related to space flight. Respir Physiol Neurobiol 169(Suppl 1):S30–S33

    Article  PubMed  Google Scholar 

  • Holguin N, Uzer G, Chiang FP, Rubin CT, Judex S (2011) Brief daily exposure to low intensity vibration mitigates the degradation of the intervertebral disc in a frequency-specific manner. J Appl Physiol 111(6):1846–1853

    Article  PubMed  Google Scholar 

  • Iwasaki KI, Sasaki T, Hirayanagi K, Yajima K (2001) Usefulness of daily +2Gz load as a countermeasure against physiological problems during weightlessness. Acta Astronaut 49:227–235

    Article  PubMed  CAS  Google Scholar 

  • Iwase S (2005) Effectiveness of centrifuge-induced artificial gravity with ergometric exercise as a countermeasure during simulated microgravity exposure in humans. Acta Astronaut 57:75–80

    Article  PubMed  Google Scholar 

  • Iwase S, Takada H, Watanabe Y, Ishida K, Akima H, Katayama K, Iwase M, Hirayanagi K, Shiozawa T, Hamaoka T, Masuo Y, Custaud MA (2004) Effect of centrifuge-induced artificial gravity and ergometric exercise on cardiovascular deconditioning, myatrophy, and osteoporosis induced by a -6 degrees head-down bedrest. J Gravit Physiol: J Int Soc Gravitat Physiol 11:P243–P244

    Google Scholar 

  • Kang CY, Zou L, Yuan M, Wang Y, Li TZ, Zhang Y, Wang JF, Li Y, Deng XW, Liu CT (2011) Impact of simulated microgravity on microvascular endothelial cell apoptosis. Eur J Appl Physiol 111:2131–2138

    Article  PubMed  Google Scholar 

  • Katkov VE, Chestukhin VV (1980) Blood pressure and oxygenation in different cardiovascular compartments of a normal man during postural exposures. Aviat Space Environ Med 51:1234–1242

    PubMed  CAS  Google Scholar 

  • Kirsch KA, Baartz FJ, Gunga HC, Rocker L (1993) Fluid shifts into and out of superficial tissues under microgravity and terrestrial conditions. Clin Investig 71:687–689

    Article  PubMed  CAS  Google Scholar 

  • Kozlovskaya IB, Grigoriev AI, Stepantzov VI (1995) Countermeasure of the negative effects of weightlessness on physical systems in long-term space flights. Acta Astronaut 36:661–668

    Article  PubMed  CAS  Google Scholar 

  • Leach CS, Alfrey CP, Suki WN, Leonard JI, Rambaut PC, Inners LD, Smith SM, Lane HW, Krauhs JM (1996) Regulation of body fluid compartments during short-term spaceflight. J Appl Physiol 81:105–116

    Google Scholar 

  • LeBlanc AD, Spector ER, Evans HJ, Sibonga JD (2007) Skeletal responses to space flight and the bed rest analog: a review. J Musculoskelet Neuronal Interact 7:33–47

    PubMed  CAS  Google Scholar 

  • Lee SM, Bennett BS, Hargens AR, Watenpaugh DE, Ballard RE, Murthy G, Ford SR, Fortney SM (1997) Upright exercise or supine lower body negative pressure exercise maintains exercise responses after bed rest. Med Sci Sports Exerc 29:892–900

    Article  PubMed  CAS  Google Scholar 

  • Lee SM, Schneider SM, Boda WL, Watenpaugh DE, Macias BR, Meyer RS, Hargens AR (2007) Supine LBNP exercise maintains exercise capacity in male twins during 30-d bed rest. Med Sci Sports Exerc 39:1315–1326

    Article  PubMed  Google Scholar 

  • Lee SM, Schneider SM, Boda WL, Watenpaugh DE, Macias BR, Meyer RS, Hargens AR (2009) LBNP exercise protects aerobic capacity and sprint speed of female twins during 30 days of bed rest. J Appl Physiol 106:919–928

    Article  PubMed  Google Scholar 

  • Levine BD, Zuckerman JH, Pawelczyk JA (1997) Cardiac atrophy after bed-rest deconditioning: a nonneural mechanism for orthostatic intolerance. Circulation 96:517–525

    Article  PubMed  CAS  Google Scholar 

  • Lueken SA, Arnaud SB, Taylor AK, Baylink DJ (1993) Changes in markers of bone formation and resorption in a bed rest model of weightlessness. J Bone Miner Res: Off J Am Soc Bone Miner Res 8:1433–1438

    Article  CAS  Google Scholar 

  • MacDougall JD, Tuxen D, Sale DG, Moroz JR, Sutton JR (1985) Arterial blood pressure response to heavy resistance exercise. J Appl Physiol 58:785–790

    PubMed  CAS  Google Scholar 

  • Macias BR, Cao P, Watenpaugh DE, Hargens AR (2007) LBNP treadmill exercise maintains spine function and muscle strength in identical twins during 28-day simulated microgravity. J Appl Physiol 102:2274–2278

    Article  PubMed  Google Scholar 

  • Mader TH, Gibson CR, Pass AF, Kramer LA, Lee AG, Fogarty J, Tarver WJ, Dervay JP, Hamilton DR, Sargsyan A, Phillips JL, Tran D, Lipsky W, Choi J, Stern C, Kuyumjian R, Polk JD (2011) Optic disc edema, globe flattening, choroidal folds, and hyperopic shifts observed in astronauts after long-duration space flight. Ophthalmology 118:2058–2069

    Article  PubMed  Google Scholar 

  • McCrory JL, Lemmon DR, Sommer HJ, Prout B, Smith D, Korth DW, Lucero J, Greenisen M, Moore J, Kozlovskaya I, Pestov I, Stepansov V, Miyakinchenko Y, Cavanagh PR (1999) Evaluation of a Treadmill with Vibration Isolation and Stabilization (TVIS) for use on the International Space Station. J Appl Biomech 15:292–302

    PubMed  CAS  Google Scholar 

  • Miokovic T, Armbrecht G, Felsenberg D, Belavy DL (2011) Differential atrophy of the postero-lateral hip musculature during prolonged bedrest and the influence of exercise countermeasures. J Appl Physiol 110:926–934

    Article  PubMed  Google Scholar 

  • Monga M, Macias B, Groppo E, Kostelec M, Hargens A (2006) Renal stone risk in a simulated microgravity environment: impact of treadmill exercise with lower body negative pressure. J Urol 176:127–131

    Article  PubMed  Google Scholar 

  • Moore AD, Lee SMC, Stenger MB, Platts SH (2010) Cardiovascular exercise in the U.S. space program: past, present and future. Acta astronautica 66:974–978

    Google Scholar 

  • Mulder ER, Stegeman DF, Gerrits KH, Paalman MI, Rittweger J, Felsenberg D, de Haan A (2006) Strength, size and activation of knee extensors followed during 8 weeks of horizontal bed rest and the influence of a countermeasure. Eur J Appl Physiol 97:706–715

    Article  PubMed  CAS  Google Scholar 

  • Paddon-Jones D, Sheffield-Moore M, Cree MG, Hewlings SJ, Aarsland A, Wolfe RR, Ferrando AA (2006) Atrophy and impaired muscle protein synthesis during prolonged inactivity and stress. J Clin Endocrinol Metab 91:4836–4841

    Article  PubMed  CAS  Google Scholar 

  • Parazynski SE, Hargens AR, Tucker B, Aratow M, Styf J, Crenshaw A (1991) Transcapillary fluid shifts in tissues of the head and neck during and after simulated microgravity. J Appl Physiol 71:2469–2475

    PubMed  CAS  Google Scholar 

  • Pavy-Le Traon A, Heer M, Narici MV, Rittweger J, Vernikos J (2007) From space to Earth: advances in human physiology from 20 years of bed rest studies (1986-2006). Eur J Appl Physiol 101:143–194

  • Prisby RD, Wilkerson MK, Sokoya EM, Bryan RM Jr, Wilson E, Delp MD (2006) Endothelium-dependent vasodilation of cerebral arteries is altered with simulated microgravity through nitric oxide synthase and EDHF mechanisms. J Appl Physiol 101:348–353

    Article  PubMed  CAS  Google Scholar 

  • Polk JD (2009) Flight Surgeon Perspective: Gaps in human health, performance, and safety. In: Committee of the decadal survey on biological and physical sciences in space. National Research Council, Washington, D.C

  • Rice L, Alfrey CP (2005) The negative regulation of red cell mass by neocytolysis: physiologic and pathophysiologic manifestations. Cell Physiol Biochem: Int J Exp Cell Physiol Biochem Pharmacol 15:245–250

    Article  CAS  Google Scholar 

  • Schneider SM, Schneider VS, Greenleaf JE (1996) The Physiology of bed rest. Handbook of physiology, pp 889–939

  • Schneider SM, Watenpaugh DE, Lee SM, Ertl AC, Williams WJ, Ballard RE, Hargens AR (2002) Lower-body negative-pressure exercise and bed-rest-mediated orthostatic intolerance. Med Sci Sports Exerc 34:1446–1453

    Article  PubMed  Google Scholar 

  • Schneider SM, Lee SM, Macias BR, Watenpaugh DE, Hargens AR (2009) WISE-2005: exercise and nutrition countermeasures for upright VO2pk during bed rest. Med Sci Sports Exerc 41:2165–2176

    Article  PubMed  Google Scholar 

  • Smith SM, Davis-Street JE, Fesperman JV, Calkins DS, Bawa M, Macias BR, Meyer RS, Hargens AR (2003) Evaluation of treadmill exercise in a lower body negative pressure chamber as a countermeasure for weightlessness-induced bone loss: a bed rest study with identical twins. J Bone Miner Res: Off J Am Soc Bone Miner Res 18:2223–2230

    Article  Google Scholar 

  • Smith SM, Zwart SR, Block G, Rice BL, Davis-Street JE (2005) The nutritional status of astronauts is altered after long-term space flight aboard the International Space Station. J Nutr 135:437–443

    PubMed  CAS  Google Scholar 

  • Stein TP, Leskiw MJ, Schluter MD, Donaldson MR, Larina I (1999a) Protein kinetics during and after long-duration spaceflight on MIR. Am J Physiol 276:E1014–E1021

    PubMed  CAS  Google Scholar 

  • Stein TP, Leskiw MJ, Schluter MD, Hoyt RW, Lane HW, Gretebeck RE, LeBlanc AD (1999b) Energy expenditure and balance during spaceflight on the space shuttle. Am J Physiol 276:R1739–R1748

    PubMed  CAS  Google Scholar 

  • Stenger MB, Evans JM, Knapp CF, Lee SM, Phillips TR, Perez SA, Moore AD Jr, Paloski WH, Platts SH (2012) Artificial gravity training reduces bed rest-induced cardiovascular deconditioning. Eur J Appl Physiol 112:605–616

    Article  PubMed  Google Scholar 

  • Trappe SW, Trappe TA, Lee GA, Widrick JJ, Costill DL, Fitts RH (2001) Comparison of a space shuttle flight (STS-78) and bed rest on human muscle function. J Appl Physiol 91:57–64

    PubMed  CAS  Google Scholar 

  • Trappe S, Trappe T, Gallagher P, Harber M, Alkner B, Tesch P (2004) Human single muscle fibre function with 84 day bed-rest and resistance exercise. J Physiol 557:501–513

    Article  PubMed  CAS  Google Scholar 

  • Trappe S, Creer A, Slivka D, Minchev K, Trappe T (2007) Single muscle fiber function with concurrent exercise or nutrition countermeasures during 60 days of bed rest in women. J Appl Physiol 103:1242–1250

    Article  PubMed  Google Scholar 

  • Trappe S, Creer A, Minchev K, Slivka D, Louis E, Luden N, Trappe T (2008) Human soleus single muscle fiber function with exercise or nutrition countermeasures during 60 days of bed rest. Am J Physiol Regul Integr Comp Physiol 294:R939–R947

    Article  PubMed  CAS  Google Scholar 

  • Trappe S, Costill D, Gallagher P, Creer A, Peters JR, Evans H, Riley DA, Fitts RH (2009) Exercise in space: human skeletal muscle after 6 months aboard the International Space Station. J Appl Physiol 106:1159–1168

    Article  PubMed  Google Scholar 

  • Watenpaugh DE (2001) Fluid volume control during short-term space flight and implications for human performance. J Exp Biol 204:3209–3215

    PubMed  CAS  Google Scholar 

  • Watenpaugh DE, Ballard RE, Schneider SM, Lee SM, Ertl AC, William JM, Boda WL, Hutchinson KJ, Hargens AR (2000) Supine lower body negative pressure exercise during bed rest maintains upright exercise capacity. J Appl Physiol 89:218–227

    PubMed  CAS  Google Scholar 

  • Watenpaugh DE, Hargens AR (1996) The cardiovascular system in microgravity. Handbook of physiology, pp 631–674

  • Watenpaugh DE, O’Leary DD, Schneider SM, Lee SM, Macias BR, Tanaka K, Hughson RL, Hargens AR (2007) Lower body negative pressure exercise plus brief postexercise lower body negative pressure improve post-bed rest orthostatic tolerance. J Appl Physiol 103:1964–1972

    Article  PubMed  Google Scholar 

  • Wilkerson MK, Lesniewski LA, Golding EM, Bryan RM Jr, Amin A, Wilson E, Delp MD (2005) Simulated microgravity enhances cerebral artery vasoconstriction and vascular resistance through endothelial nitric oxide mechanism. Am J Physiol Heart Circ Physiol 288:H1652–H1661

    Article  PubMed  CAS  Google Scholar 

  • Yuan M, Coupe M, Bai Y, Gauquelin-Koch G, Jiang S, Aubry P, Wan Y, Custaud MA, Li Y, Arbeille P (2012) Peripheral arterial and venous response to tilt test after a 60-day bedrest with and without countermeasures (ES-IBREP). PLoS One 7:e32854

    Article  PubMed  CAS  Google Scholar 

  • Zhang LF (2004) Vascular adaptation to microgravity. J Appl Physiol 97:1584–1585 author reply 1585–1587

    Article  PubMed  Google Scholar 

  • Zwart SR, Hargens AR, Lee SM, Macias BR, Watenpaugh DE, Tse K, Smith SM (2007) Lower body negative pressure treadmill exercise as a countermeasure for bed rest-induced bone loss in female identical twins. Bone 40:529–537

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Orthopedic Surgery, University of California San Diego, San Diego, CA, 92103-8894, USA

    Alan R. Hargens & Roshmi Bhattacharya

  2. Department of Health, Exercise and Sports Sciences, University of New Mexico, Albuquerque, NM, 87131, USA

    Suzanne M. Schneider

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  1. Alan R. Hargens
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  2. Roshmi Bhattacharya
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  3. Suzanne M. Schneider
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Correspondence to Alan R. Hargens.

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Communicated by Nigel A.S. Taylor.

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Hargens, A.R., Bhattacharya, R. & Schneider, S.M. Space physiology VI: exercise, artificial gravity, and countermeasure development for prolonged space flight. Eur J Appl Physiol 113, 2183–2192 (2013). https://doi.org/10.1007/s00421-012-2523-5

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