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Synthetic Charge-Invertible Polymer for Rapid and Complete Implantation of Layer-by-Layer Microneedle Drug Films for Enhanced Transdermal Vaccination

  • Yanpu He
    Yanpu He
    Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    More by Yanpu He
  • , 
  • Celestine Hong
    Celestine Hong
    Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    More by Celestine Hong
  • , 
  • Jiahe Li
    Jiahe Li
    Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    More by Jiahe Li
    Orcidhttp://orcid.org/0000-0002-9889-8546
  • , 
  • MayLin T. Howard
    MayLin T. Howard
    Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    More by MayLin T. Howard
  • , 
  • Yingzhong Li
    Yingzhong Li
    Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    More by Yingzhong Li
  • , 
  • Michelle E. Turvey
    Michelle E. Turvey
    Infectious Diseases Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology (SMART), Singapore, Singapore
    More by Michelle E. Turvey
  • , 
  • Divakara S. S. M. Uppu
    Divakara S. S. M. Uppu
    Infectious Diseases Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology (SMART), Singapore, Singapore
    More by Divakara S. S. M. Uppu
  • , 
  • John R. Martin
    John R. Martin
    Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    More by John R. Martin
  • , 
  • Ketian Zhang
    Ketian Zhang
    Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    More by Ketian Zhang
  • , 
  • Darrell J. Irvine
    Darrell J. Irvine
    Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, United States
    More by Darrell J. Irvine
    Orcidhttp://orcid.org/0000-0002-8637-1405
  • , and 
  • Paula T. Hammond*
    Paula T. Hammond
    Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States
    *E-mail: [email protected]
    More by Paula T. Hammond
    Orcidhttp://orcid.org/0000-0002-9835-192X
Cite this: ACS Nano 2018, 12, 10, 10272–10280
Publication Date (Web):October 1, 2018
https://doi.org/10.1021/acsnano.8b05373
Copyright © 2018 American Chemical Society
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    Abstract

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    The utility of layer-by-layer (LbL) coated microneedle (MN) skin patches for transdermal drug delivery has proven to be a promising approach, with advantages over hypodermal injection due to painless and easy self-administration. However, the long epidermal application time required for drug implantation by existing LbL MN strategies (15–90 min) can lead to potential medication noncompliance. Here, we developed a MN platform to shorten the application time in MN therapies based on a synthetic pH-induced charge-invertible polymer poly(2-(diisopropylamino) ethyl methacrylate-b-methacrylic acid) (PDM), requiring only 1 min skin insertion time to implant LbL films in vivo. Following MN-mediated delivery of 0.5 μg model antigen chicken ovalbumin (OVA) in the skin of mice, this system achieved sustained release over 3 days and led to an elevated immune response as demonstrated by significantly higher humoral immunity compared with OVA administration via conventional routes (subcutaneously and intramuscularly). Moreover, in an ex vivo experiment on human skin, we achieved efficient immune activation through MN-delivered LbL films, demonstrated by a rapid uptake of vaccine adjuvants by the antigen presenting cells. These features, rapid administration and the ability to elicit a robust immune response, can potentially enable a broad application of microneedle-based vaccination technologies.

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acsnano.8b05373.

    • TEM micrographs of PDM in pH 4.2 and pH 7.5, images of (lyso/PAA) LbL film coated silicon wafers, synthesis scheme of HMDS-mediated NCA ring-opening polymerization of PBLA backbone, and the following amination reaction to form PAsp(EDDPA), scanning electron microscopic images of the cross sections of (A) uncoated PLLA MN and (B) [PAsp(EDDPA)/OVA]40-PDM coated PLLA MN, cell viability test with NIH3T3 cells subject to 50, 10, 1, 0.2, and 0.1 μg/mL PDM polymer, and materials and methods (PDF)

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    3. Eugene Froimchuk, Sean T. Carey, Camilla Edwards, Christopher M. Jewell. Self-Assembly as a Molecular Strategy to Improve Immunotherapy. Accounts of Chemical Research 2020, 53 (11) , 2534-2545. https://doi.org/10.1021/acs.accounts.0c00438
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    7. Dan Dan Zhu, Xiao Li Wang, Xiao Peng Zhang, Jing Jing Ma, De Ling Kong, Ming Ming Zhang, Xin Dong Guo, Chun Wang. A Dissolvable Microneedle Formulation of Bordetella pertussis Subunit Vaccine: Translational Development and Immunological Evaluation in Mice. ACS Applied Bio Materials 2019, 2 (11) , 5053-5061. https://doi.org/10.1021/acsabm.9b00730
    8. Gu Cheng, Chengcheng Yin, Hu Tu, Shan Jiang, Qun Wang, Xue Zhou, Xin Xing, Congyong Xie, Xiaowen Shi, Yuming Du, Hongbing Deng, Zubing Li. Controlled Co-delivery of Growth Factors through Layer-by-Layer Assembly of Core–Shell Nanofibers for Improving Bone Regeneration. ACS Nano 2019, 13 (6) , 6372-6382. https://doi.org/10.1021/acsnano.8b06032
    9. Haolan Zhang, Danyu Wang, Xingang Zuo, Changyou Gao. UV-Responsive Multilayers with Multiple Functions for Biofilm Destruction and Tissue Regeneration. ACS Applied Materials & Interfaces 2019, 11 (19) , 17283-17293. https://doi.org/10.1021/acsami.9b04428
    10. Sadegh Shabani, Sara Hadjigol, Wenyi Li, Zhangyong Si, Dicky Pranantyo, Mary B. Chan-Park, Neil M. O’Brien-Simpson, Greg G. Qiao. Synthetic peptide branched polymers for antibacterial and biomedical applications. Nature Reviews Bioengineering 2024, 2 (4) , 343-361. https://doi.org/10.1038/s44222-023-00143-4
    11. Yue Yin, Junyuan Yang, Ge Gao, Huaijuan Zhou, Bowen Chi, Hong Yu Yang, Jinhua Li, Yilong Wang. Enhancing cell-scale performance via sustained release of the varicella-zoster virus antigen from a microneedle patch under simulated microgravity. Biomaterials Science 2024, 12 (3) , 763-775. https://doi.org/10.1039/D3BM01440A
    12. João Borges, Jinfeng Zeng, Xi Qiu Liu, Hao Chang, Claire Monge, Charlotte Garot, Ke‐feng Ren, Paul Machillot, Nihal E. Vrana, Philippe Lavalle, Takami Akagi, Michiya Matsusaki, Jian Ji, Mitsuru Akashi, João F. Mano, Varvara Gribova, Catherine Picart. Recent Developments in Layer‐by‐Layer Assembly for Drug Delivery and Tissue Engineering Applications. Advanced Healthcare Materials 2024, 8 https://doi.org/10.1002/adhm.202302713
    13. Qian Wu, Chen Pan, Puhuan Shi, Lei Zou, Shiya Huang, Ningning Zhang, Sen-Sen Li, Qian Chen, Yi Yang, Lu-Jian Chen, Xuejia Hu. On-demand transdermal drug delivery platform based on wearable acoustic microneedle array. Chemical Engineering Journal 2023, 477 , 147124. https://doi.org/10.1016/j.cej.2023.147124
    14. Minhui Lu, Xiaoxuan Zhang, Zhiqiang Luo, Yuanjin Zhao. Developing hierarchical microneedles for biomedical applications. Engineered Regeneration 2023, 4 (3) , 316-327. https://doi.org/10.1016/j.engreg.2023.04.004
    15. Mohammad Dahri, Nima Beheshtizadeh, Nasrin Seyedpour, Amin Nakhostin-Ansari, Faezeh Aghajani, Simin Seyedpour, Moein Masjedi, Fatemeh Farjadian, Reza Maleki, Khosro Adibkia. Biomaterial-based delivery platforms for transdermal immunotherapy. Biomedicine & Pharmacotherapy 2023, 165 , 115048. https://doi.org/10.1016/j.biopha.2023.115048
    16. Eduardo Guzmán, Francisco Ortega, Ramón G. Rubio. Layer-by-Layer Nanoassemblies for Vaccination Purposes. Pharmaceutics 2023, 15 (5) , 1449. https://doi.org/10.3390/pharmaceutics15051449
    17. Weiqiang Han, Fengyu Liu, Guoxin Liu, Hongjuan Li, Yongqian Xu, Shiguo Sun. Research progress of physical transdermal enhancement techniques in tumor therapy. Chemical Communications 2023, 59 (23) , 3339-3359. https://doi.org/10.1039/D2CC06219D
    18. Tomás Bauleth-Ramos, Nesma El-Sayed, Flavia Fontana, Maria Lobita, Mohammad-Ali Shahbazi, Hélder A. Santos. Recent approaches for enhancing the performance of dissolving microneedles in drug delivery applications. Materials Today 2023, 63 , 239-287. https://doi.org/10.1016/j.mattod.2022.12.007
    19. Selvaraj Sengottiyan, Alicja Mikolajczyk, Tomasz Puzyn. How Does the Study MD of pH-Dependent Exposure of Nanoparticles Affect Cellular Uptake of Anticancer Drugs?. International Journal of Molecular Sciences 2023, 24 (4) , 3479. https://doi.org/10.3390/ijms24043479
    20. Jinying Lv, Hongyu Ma, Gengsheng Ye, Shiami Jia, Juan He, Wuni Jiaduo, Jie Ma, Yan Qu, Kaijun Gou, Rui Zeng. Bilayer microneedles based on Bletilla striata polysaccharide containing asiaticoside effectively promote scarless wound healing. Materials & Design 2023, 226 , 111655. https://doi.org/10.1016/j.matdes.2023.111655
    21. André F. Moreira, Carolina F. Rodrigues, Natanael Fernandes, André Figueiredo, Duarte de Melo-Diogo, Ilídio J. Correia. Polymeric Microneedle-Based Drug Delivery Platforms for Application in Cancer Therapy. 2023, 309-324. https://doi.org/10.1007/978-3-031-17831-3_11
    22. Simin Seyedpour, Nima Rezaei. Clinical Applications of Novel Delivery Routes of Immunotherapy Drugs and Vaccines. 2023, 1-25. https://doi.org/10.1007/978-3-030-80962-1_209-1
    23. Shuo Wang, Mengmeng Zhao, Yibo Yan, Peng Li, Wei Huang. Flexible Monitoring, Diagnosis, and Therapy by Microneedles with Versatile Materials and Devices toward Multifunction Scope. Research 2023, 6 https://doi.org/10.34133/research.0128
    24. Kentaro Yoshida, Toshio Kamijo, Tetsuya Ono, Takenori Dairaku, Shigehiro Takahashi, Yoshitomo Kashiwagi, Katsuhiko Sato. Electrical Stimuli-Responsive Decomposition of Layer-by-Layer Films Composed of Polycations and TEMPO-Modified Poly(acrylic acid). Polymers 2022, 14 (24) , 5349. https://doi.org/10.3390/polym14245349
    25. Guo Xu, Yukuan Mao, Tianyue Jiang, Bingbing Gao, Bingfang He. Structural design strategies of microneedle-based vaccines for transdermal immunity augmentation. Journal of Controlled Release 2022, 351 , 907-922. https://doi.org/10.1016/j.jconrel.2022.10.008
    26. Shiqi Huang, Yining Zhu, Ling Zhang, Zhirong Zhang. Recent Advances in Delivery Systems for Genetic and Other Novel Vaccines. Advanced Materials 2022, 34 (46) https://doi.org/10.1002/adma.202107946
    27. Nejla Cini, Ferah Calisir. Layer-by-layer self-assembled emerging systems for nanosized drug delivery. Nanomedicine 2022, 17 (25) , 1961-1980. https://doi.org/10.2217/nnm-2022-0254
    28. Deepak Poddar, Purnima Jain. Surface modification of three-dimensional porous polymeric scaffolds in tissue engineering applications: A focus review on physical modifications methods. Polymer-Plastics Technology and Materials 2022, 61 (12) , 1308-1333. https://doi.org/10.1080/25740881.2022.2061863
    29. Junli Meng, Peisen Zhang, Qizhe Chen, Zihua Wang, Yuan Gu, Jie Ma, Wang Li, Chen Yang, Yuanyuan Qiao, Yi Hou, Lihong Jing, Yong Wang, Zi Gu, Lichong Zhu, Haozhen Xu, Xueguang Lu, Mingyuan Gao. Two‐Pronged Intracellular Co‐Delivery of Antigen and Adjuvant for Synergistic Cancer Immunotherapy. Advanced Materials 2022, 34 (21) https://doi.org/10.1002/adma.202202168
    30. Minki Jin, Woo-Jin Jeon, Haesoo Lee, Minwoo Jung, Ha-Eun Kim, Hyelim Yoo, Jong-Hee Won, Jong Chan Kim, Jung-Hwan Park, Mi-Jin Yang, Hong-Ki Lee, Cheong-Weon Cho. Preparation and evaluation of rapid disintegrating formulation from coated microneedle. Drug Delivery and Translational Research 2022, 12 (2) , 415-425. https://doi.org/10.1007/s13346-021-01046-w
    31. Yun Hao Feng, Bo Zhi Chen, Wen Min Fei, Yong Cui, Can Yang Zhang, Xin Dong Guo. Mechanism studies on the cellular internalization of nanoparticles using computer simulations: A review. AIChE Journal 2022, 68 (2) https://doi.org/10.1002/aic.17507
    32. Fateme Nazary Abrbekoh, Leila Salimi, Sepideh Saghati, Hassan Amini, Sonia Fathi Karkan, Keyvan Moharamzadeh, Emel Sokullu, Reza Rahbarghazi. Application of microneedle patches for drug delivery; doorstep to novel therapies. Journal of Tissue Engineering 2022, 13 , 204173142210853. https://doi.org/10.1177/20417314221085390
    33. Jing Liu, Si Si Liew, Jun Wang, Kanyi Pu. Bioinspired and Biomimetic Delivery Platforms for Cancer Vaccines. Advanced Materials 2022, 34 (1) https://doi.org/10.1002/adma.202103790
    34. Shuyao Ruan, Yongtai Zhang, Nianping Feng. Microneedle-mediated transdermal nanodelivery systems: a review. Biomaterials Science 2021, 9 (24) , 8065-8089. https://doi.org/10.1039/D1BM01249E
    35. Rayen Yanara Valdivia-Olivares, Maria Rodriguez-Fernandez, María Javiera Álvarez-Figueroa, Alexis M. Kalergis, José Vicente González-Aramundiz. The Importance of Nanocarrier Design and Composition for an Efficient Nanoparticle-Mediated Transdermal Vaccination. Vaccines 2021, 9 (12) , 1420. https://doi.org/10.3390/vaccines9121420
    36. Jingbo Yang, Haoxiang Zhang, Tianli Hu, Chenjie Xu, Lelun Jiang, Yu Shrike Zhang, Maobin Xie. Recent advances of microneedles used towards stimuli-responsive drug delivery, disease theranostics, and bioinspired applications. Chemical Engineering Journal 2021, 426 , 130561. https://doi.org/10.1016/j.cej.2021.130561
    37. Olivia M. Saouaf, Gillie A. Roth, Ben S. Ou, Anton A. A. Smith, Anthony C. Yu, Emily C. Gale, Abigail K. Grosskopf, Vittoria C.T.M. Picece, Eric A. Appel. Modulation of injectable hydrogel properties for slow co‐delivery of influenza subunit vaccine components enhance the potency of humoral immunity. Journal of Biomedical Materials Research Part A 2021, 109 (11) , 2173-2186. https://doi.org/10.1002/jbm.a.37203
    38. Li Zhao, Chunyang Zhang, Juhaina M. Abu‐Ershaid, Mingshan Li, Yaocun Li, Yara Naser, Xianbing Dai, Marco T. A. Abbate, Ryan F. Donnelly. Smart Responsive Microarray Patches for Transdermal Drug Delivery and Biological Monitoring. Advanced Healthcare Materials 2021, 10 (20) https://doi.org/10.1002/adhm.202100996
    39. Beibei Yang, Yating Dong, Yifeng Shen, Ailin Hou, Guilan Quan, Xin Pan, Chuanbin Wu. Bilayer dissolving microneedle array containing 5-fluorouracil and triamcinolone with biphasic release profile for hypertrophic scar therapy. Bioactive Materials 2021, 6 (8) , 2400-2411. https://doi.org/10.1016/j.bioactmat.2021.01.014
    40. Ting Liu, Minglong Chen, Jintao Fu, Ying Sun, Chao Lu, Guilan Quan, Xin Pan, Chuanbin Wu. Recent advances in microneedles-mediated transdermal delivery of protein and peptide drugs. Acta Pharmaceutica Sinica B 2021, 11 (8) , 2326-2343. https://doi.org/10.1016/j.apsb.2021.03.003
    41. Nae-Won Kang, Sungho Kim, Jae-Young Lee, Ki-Taek Kim, Yuji Choi, Yujeong Oh, Jongchan Kim, Dae-Duk Kim, Jung-Hwan Park. Microneedles for drug delivery: recent advances in materials and geometry for preclinical and clinical studies. Expert Opinion on Drug Delivery 2021, 18 (7) , 929-947. https://doi.org/10.1080/17425247.2021.1828860
    42. Dong Huang, Junshi Li, Tingyu Li, Zhongyan Wang, Qining Wang, Zhihong Li. Recent advances on fabrication of microneedles on the flexible substrate. Journal of Micromechanics and Microengineering 2021, 31 (7) , 073001. https://doi.org/10.1088/1361-6439/ac0513
    43. Ruxuan Wang, Qiong Bian, Yihua Xu, Donghang Xu, Jianqing Gao. Recent advances in mechanical force-assisted transdermal delivery of macromolecular drugs. International Journal of Pharmaceutics 2021, 602 , 120598. https://doi.org/10.1016/j.ijpharm.2021.120598
    44. Suman Pahal, Kedar Badnikar, Vivek Ghate, Utkarsh Bhutani, Mangalore Manjunatha Nayak, Dinesh Narasimhaiah Subramanyam, Praveen Kumar Vemula. Microneedles for Extended Transdermal Therapeutics: A Route to Advanced Healthcare. European Journal of Pharmaceutics and Biopharmaceutics 2021, 159 , 151-169. https://doi.org/10.1016/j.ejpb.2020.12.020
    45. Zhixiao Yao, Tong Xue, Hao Xiong, Chuandong Cai, Xudong Liu, Fei Wu, Shen Liu, Cunyi Fan. Promotion of collagen deposition during skin healing through Smad3/mTOR pathway by parathyroid hormone-loaded microneedle. Materials Science and Engineering: C 2021, 119 , 111446. https://doi.org/10.1016/j.msec.2020.111446
    46. Yanjun Li, Jingbo Yang, Ying Zheng, Rui Ye, Bin Liu, Yong Huang, Wei Zhou, Lelun Jiang. Iontophoresis-driven porous microneedle array patch for active transdermal drug delivery. Acta Biomaterialia 2021, 121 , 349-358. https://doi.org/10.1016/j.actbio.2020.12.023
    47. Joëlle Bizeau, Damien Mertz. Design and applications of protein delivery systems in nanomedicine and tissue engineering. Advances in Colloid and Interface Science 2021, 287 , 102334. https://doi.org/10.1016/j.cis.2020.102334
    48. Lin-yu Long, Jieyu Zhang, Zeyu Yang, Yi Guo, Xuefeng Hu, Yunbing Wang. Transdermal delivery of peptide and protein drugs: Strategies, advantages and disadvantages. Journal of Drug Delivery Science and Technology 2020, 60 , 102007. https://doi.org/10.1016/j.jddst.2020.102007
    49. Rezvan Jamaledin, Pooyan Makvandi, Cynthia K. Y. Yiu, Tarun Agarwal, Raffaele Vecchione, Wujin Sun, Tapas Kumar Maiti, Franklin R. Tay, Paolo Antonio Netti. Engineered Microneedle Patches for Controlled Release of Active Compounds: Recent Advances in Release Profile Tuning. Advanced Therapeutics 2020, 3 (12) https://doi.org/10.1002/adtp.202000171
    50. Yuanpeng Wang, Haozheng Wang, X. X. Zhu, Ying Guan, Yongjun Zhang. Smart microneedle patches for rapid, and painless transdermal insulin delivery. Journal of Materials Chemistry B 2020, 8 (40) , 9335-9342. https://doi.org/10.1039/D0TB01822H
    51. Shuangqian Yan, Zichao Luo, Zhenglin Li, Yu Wang, Jun Tao, Changyang Gong, Xiaogang Liu. Improving Cancer Immunotherapy Outcomes Using Biomaterials. Angewandte Chemie International Edition 2020, 59 (40) , 17332-17343. https://doi.org/10.1002/anie.202002780
    52. Shuangqian Yan, Zichao Luo, Zhenglin Li, Yu Wang, Jun Tao, Changyang Gong, Xiaogang Liu. Improving Cancer Immunotherapy Outcomes Using Biomaterials. Angewandte Chemie 2020, 132 (40) , 17484-17495. https://doi.org/10.1002/ange.202002780
    53. Zhixiao Yao, Tong Xue, Chuandong Cai, Juehong Li, Mingkuan Lu, Xudong Liu, Tuo Jin, Fei Wu, Shen Liu, Cunyi Fan. Parathyroid Hormone‐Loaded Microneedle Promotes Tendon Healing Through Activation of mTOR. Advanced Therapeutics 2020, 3 (8) https://doi.org/10.1002/adtp.202000025
    54. Luis Abelardo Villarruel Mendoza, Natalia Antonela Scilletta, Martin Gonzalo Bellino, Martin Federico Desimone, Paolo Nicolas Catalano. Recent Advances in Micro-Electro-Mechanical Devices for Controlled Drug Release Applications. Frontiers in Bioengineering and Biotechnology 2020, 8 https://doi.org/10.3389/fbioe.2020.00827
    55. Dahlia Alkekhia, Paula T. Hammond, Anita Shukla. Layer-by-Layer Biomaterials for Drug Delivery. Annual Review of Biomedical Engineering 2020, 22 (1) , 1-24. https://doi.org/10.1146/annurev-bioeng-060418-052350
    56. Apoorva Sarode, Akshaya Annapragada, Junling Guo, Samir Mitragotri. Layered self-assemblies for controlled drug delivery: A translational overview. Biomaterials 2020, 242 , 119929. https://doi.org/10.1016/j.biomaterials.2020.119929
    57. Sharon W. T. Chew, Ankur H. Shah, Mengjia Zheng, Hao Chang, Christian Wiraja, Terry W. J. Steele, Chenjie Xu. A self‐adhesive microneedle patch with drug loading capability through swelling effect. Bioengineering & Translational Medicine 2020, 5 (2) https://doi.org/10.1002/btm2.10157
    58. Hao Chang, Mengjia Zheng, Sharon Wan Ting Chew, Chenjie Xu. Advances in the Formulations of Microneedles for Manifold Biomedical Applications. Advanced Materials Technologies 2020, 5 (4) https://doi.org/10.1002/admt.201900552
    59. Divakara S.S.M. Uppu, Michelle E. Turvey, Abdul Rahim Mohammed Sharif, Katell Bidet, Yanpu He, Victor Ho, Anagha D. Tambe, Julien Lescar, Ern Yu Tan, Katja Fink, Jianzhu Chen, Paula T. Hammond. Temporal release of a three-component protein subunit vaccine from polymer multilayers. Journal of Controlled Release 2020, 317 , 130-141. https://doi.org/10.1016/j.jconrel.2019.11.022
    60. M. Patricia D'Souza, Shyam Rele, Barton F. Haynes, Dale J. Hu, David L. Kaplan, Shadi Mamaghani, David Rampulla. Engineering immunity for next generation HIV vaccines: The intersection of bioengineering and immunology. Vaccine 2020, 38 (2) , 187-193. https://doi.org/10.1016/j.vaccine.2019.10.036
    61. Kevin J. McHugh, Lihong Jing, Sean Y. Severt, Mache Cruz, Morteza Sarmadi, Hapuarachchige Surangi N. Jayawardena, Collin F. Perkinson, Fridrik Larusson, Sviatlana Rose, Stephanie Tomasic, Tyler Graf, Stephany Y. Tzeng, James L. Sugarman, Daniel Vlasic, Matthew Peters, Nels Peterson, Lowell Wood, Wen Tang, Jihyeon Yeom, Joe Collins, Philip A. Welkhoff, Ari Karchin, Megan Tse, Mingyuan Gao, Moungi G. Bawendi, Robert Langer, Ana Jaklenec. Biocompatible near-infrared quantum dots delivered to the skin by microneedle patches record vaccination. Science Translational Medicine 2019, 11 (523) https://doi.org/10.1126/scitranslmed.aay7162
    62. Parbeen Singh, Andrew Carrier, Yongli Chen, Sujing Lin, Jinlin Wang, Shufen Cui, Xu Zhang. Polymeric microneedles for controlled transdermal drug delivery. Journal of Controlled Release 2019, 315 , 97-113. https://doi.org/10.1016/j.jconrel.2019.10.022
    63. Yi Li, Hong Yu Yang, Thavasyappan Thambi, Jae-Hyung Park, Doo Sung Lee. Charge-convertible polymers for improved tumor targeting and enhanced therapy. Biomaterials 2019, 217 , 119299. https://doi.org/10.1016/j.biomaterials.2019.119299
    64. André F. Moreira, Carolina F. Rodrigues, Telma A. Jacinto, Sónia P. Miguel, Elisabete C. Costa, Ilídio J. Correia. Microneedle-based delivery devices for cancer therapy: A review. Pharmacological Research 2019, 148 , 104438. https://doi.org/10.1016/j.phrs.2019.104438
    65. Karoline E. Eckhart, Brian D. Holt, Michaela G. Laurencin, Stefanie A. Sydlik. Covalent conjugation of bioactive peptides to graphene oxide for biomedical applications. Biomaterials Science 2019, 7 (9) , 3876-3885. https://doi.org/10.1039/C9BM00867E
    66. Won-Gyu Bae, Hangil Ko, Jin-Young So, Hoon Yi, Chan-Ho Lee, Dong-Hun Lee, Yujin Ahn, Sang-Hyeon Lee, Kyunghun Lee, Joonha Jun, Hyoung-Ho Kim, Noo Li Jeon, Woonggyu Jung, Chang-Seon Song, Taesung Kim, Yeu-Chun Kim, Hoon Eui Jeong. Snake fang–inspired stamping patch for transdermal delivery of liquid formulations. Science Translational Medicine 2019, 11 (503) https://doi.org/10.1126/scitranslmed.aaw3329
    67. Zhipeng Chen, Rui Ye, Weihsien Lee, Dianwen Jin, Yuanxi Zhang, Liyuan Jiang, Yilin Yang, Lei Ren, Lelun Jiang. Magnetization‐Induced Self‐Assembling of Bendable Microneedle Arrays for Triboelectric Nanogenerators. Advanced Electronic Materials 2019, 5 (5) https://doi.org/10.1002/aelm.201800785
    68. Tan Tang, Tujun Weng, Hongxing Jia, Sida Luo, Ye Xu, Liuhe Li, Peipei Zhang. Harnessing the layer-by-layer assembly technique to design biomaterials vaccines for immune modulation in translational applications. Biomaterials Science 2019, 7 (3) , 715-732. https://doi.org/10.1039/C8BM01219A
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