Abstract
In addition to its previously characterized, six different polypeptide components, signal recognition protein--which functions in protein translocation across and integration into the endoplasmic reticulum membrane--contains a 7S RNA molecule. The RNA is closely identified with the small cytoplasmic 7SL RNA and is required for both structural and functional properties of signal recognition protein--which we therefore rename signal recognition particle.
Publication types
- Research Support, Non-U.S. Gov't
- Research Support, U.S. Gov't, P.H.S.
MeSH terms
- Animals
- Base Sequence
- Biological Transport
- Dogs
- Endoplasmic Reticulum / physiology*
- Macromolecular Substances
- Membrane Proteins / physiology
- Peptides / metabolism*
- Peptides / physiology
- Protein Precursors / metabolism*
- Protein Sorting Signals
- RNA / physiology*
- RNA, Small Nuclear
- Ribonucleoproteins / physiology
- Ribonucleoproteins, Small Nuclear
- Ribosomes / metabolism*
Substances
- Macromolecular Substances
- Membrane Proteins
- Peptides
- Protein Precursors
- Protein Sorting Signals
- RNA, Small Nuclear
- Ribonucleoproteins
- Ribonucleoproteins, Small Nuclear
- RNA