Abstract
Hypoxia-inducible factor (HIF)-1α and HIF-2α expression were investigated immunohistochemically as determinants of prognosis in 42 cases of astrocytic tumors associated with necrosis grade on magnetic resonance (MR) imaging. Expression of HIF-1α was determined immunohistologically. The degree of necrosis on MR images was divided into four grades. Kaplan–Meier analysis revealed a significant effect of necrosis grade on MR images on cumulative overall survival. Median survival times were 26, 14, and 13 months for patients with necrosis grades 1, 2, and 3, respectively (not defined for grade 0). Kaplan–Meier analysis revealed a significant effect of HIF-1α expression on cumulative overall survival. Median survival time of patients with HIF-1α expression was 17 months, whereas it was 80 months for patients without HIF-1α expression. However, overexpression of HIF-2α did not correlate with malignant features, for example angiogenesis or necrosis, and had no impact on overall survival of patients with glial tumors. In conclusion, HIF-1α, but not HIF-2α, is a useful prognostic factor in astrocytic tumor associated with necrosis on MR images.
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Abbreviations
- HIF:
-
Hypoxia-inducible factor
- GBM:
-
Glioblastoma multiforme
- VEGF:
-
Vascular endothelial growth factor
- MR image:
-
Magnetic resonance image
- MVD:
-
Microvascular density
- ELISA:
-
Enzyme-linked immunosorbent assay
- AA:
-
Anaplastic astrocytoma
- DA:
-
Diffuse astrocytoma
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Acknowledgements
We gratefully acknowledge Yoshiko Tsukada and Makiko Miyakawa for their excellent technical assistance. This study was supported by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science and by grants provided by the Tsukuba Advanced Research Alliance, the Japan Brain Foundation, the Japanese Foundation for Research and Promotion of Endoscopy, and the Japanese Foundation for Multidisciplinary Treatment of Cancer.
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Mashiko, R., Takano, S., Ishikawa, E. et al. Hypoxia-inducible factor 1α expression is a prognostic biomarker in patients with astrocytic tumors associated with necrosis on MR image. J Neurooncol 102, 43–50 (2011). https://doi.org/10.1007/s11060-010-0292-8
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DOI: https://doi.org/10.1007/s11060-010-0292-8