Elsevier

Results in Immunology

Volume 6, 2016, Pages 8-10
Results in Immunology

Short communication
Ascorbic acid serum levels are reduced in patients with hematological malignancies

https://doi.org/10.1016/j.rinim.2016.01.001 Get rights and content
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Abstract

In this paper we demonstrate that patients treated with chemotherapy and/or hematopoietic stem cell transplantation (HSCT) have highly significant reduced serum ascorbic acid (AA) levels compared to healthy controls. We recently observed in in vitro experiments that growth of both T and NK cells from hematopoietic stem cells is positively influenced by AA. It might be of clinical relevance to study the function and recovery of immune cells after intensive treatment, its correlation to AA serum levels and the possible effect of AA supplementation.

Keywords

Ascorbic acid
Vitamin C
Hematological malignancy
Hematopoietic stem cell transplantation
Chemotherapy

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