Effects of turmeric and curcumin on oral mucositis: A systematic review
Ana Gabriela Costa Normando
Laboratory of Oral Histopathology, Health Sciences Faculty, University of Brasilia, Brasilia, Brazil
Search for more papers by this authorAmanda Gomes de Menêses
Interdisciplinary Laboratory of Applied Research on Clinical Practice in Oncology, Health Sciences Faculty, University of Brasilia, Brasilia, Brazil
Search for more papers by this authorIsabela Porto de Toledo
Laboratory of Oral Histopathology, Health Sciences Faculty, University of Brasilia, Brasilia, Brazil
Brazilian Centre for Evidence-Based Research, Department of Dentistry, Federal University of Santa Catarina, Florianópolis, Brazil
Search for more papers by this authorGabriel Álvares Borges
Laboratory of Oral Histopathology, Health Sciences Faculty, University of Brasilia, Brasilia, Brazil
Search for more papers by this authorCaroline Lourenço de Lima
Laboratory of Oral Histopathology, Health Sciences Faculty, University of Brasilia, Brasilia, Brazil
Search for more papers by this authorPaula Elaine Diniz dos Reis
Interdisciplinary Laboratory of Applied Research on Clinical Practice in Oncology, Health Sciences Faculty, University of Brasilia, Brasilia, Brazil
Search for more papers by this authorCorresponding Author
Eliete Neves Silva Guerra
Laboratory of Oral Histopathology, Health Sciences Faculty, University of Brasilia, Brasilia, Brazil
Correspondence
Prof. Dr. Eliete Neves Silva Guerra SQN 205, bloco H, apto 201, Asa Norte, Brasília 70843-080, DF, Brazil.
Email: [email protected]
Search for more papers by this authorAna Gabriela Costa Normando
Laboratory of Oral Histopathology, Health Sciences Faculty, University of Brasilia, Brasilia, Brazil
Search for more papers by this authorAmanda Gomes de Menêses
Interdisciplinary Laboratory of Applied Research on Clinical Practice in Oncology, Health Sciences Faculty, University of Brasilia, Brasilia, Brazil
Search for more papers by this authorIsabela Porto de Toledo
Laboratory of Oral Histopathology, Health Sciences Faculty, University of Brasilia, Brasilia, Brazil
Brazilian Centre for Evidence-Based Research, Department of Dentistry, Federal University of Santa Catarina, Florianópolis, Brazil
Search for more papers by this authorGabriel Álvares Borges
Laboratory of Oral Histopathology, Health Sciences Faculty, University of Brasilia, Brasilia, Brazil
Search for more papers by this authorCaroline Lourenço de Lima
Laboratory of Oral Histopathology, Health Sciences Faculty, University of Brasilia, Brasilia, Brazil
Search for more papers by this authorPaula Elaine Diniz dos Reis
Interdisciplinary Laboratory of Applied Research on Clinical Practice in Oncology, Health Sciences Faculty, University of Brasilia, Brasilia, Brazil
Search for more papers by this authorCorresponding Author
Eliete Neves Silva Guerra
Laboratory of Oral Histopathology, Health Sciences Faculty, University of Brasilia, Brasilia, Brazil
Correspondence
Prof. Dr. Eliete Neves Silva Guerra SQN 205, bloco H, apto 201, Asa Norte, Brasília 70843-080, DF, Brazil.
Email: [email protected]
Search for more papers by this authorAbstract
The aim of this study was to evaluate the effects of turmeric and curcumin in the management of oral mucositis in cancer patients undergoing chemo and/or radiotherapy. The systematic review was reported according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses. The search was performed in the following database: Cochrane Library, LILACS, LIVIVO, PubMed, Scopus, and Web of Science. A gray literature search was undertaken using Google Scholar, Open Grey, and ProQuest. The methodology of included studies was evaluated by the Meta-Analysis of Statistics Assessment and Review Instrument. After a two-step selection process, four randomized and one nonrandomized clinical trials were included in the analysis. Two studies were categorized as low and three as moderate risk of bias. Turmeric/curcumin was applied topically as a gel or as a mouthwash. Patients treated with turmeric/curcumin experienced reduced grade of mucositis, pain, erythema intensity, and ulcerative area. Current evidence suggests that topical application of turmeric or curcumin is effective in controlling signs and symptoms of oral mucositis. Thus, further investigation is required to confirm the promising effect of turmeric and curcumin in oral inflammatory lesions.
CONFLICTS OF INTEREST
None declared.
Supporting Information
| Filename | Description |
|---|---|
| ptr6326-sup-0001-Appendix 1.docxWord 2007 document , 498.6 KB | Data S1. Appendix 1. Search strategies with appropriated key words and Mesh terms. |
| ptr6326-sup-0002-Appendix 2.docxWord 2007 document , 506.2 KB | Data S2. Appendix 2. Excluded articles and reasons for exclusion (n = 17). |
| ptr6326-sup-0003-Appendix 3.docxWord 2007 document , 50.5 KB | Data S3. Appendix 3. Risk of bias assessed by Meta Analysis of Statistics Assessment and Review Instrument (MAStARI)1 critical appraisal tools. Risk of bias was categorized as High when the study reaches up to 49% score “yes”, Moderate when the study reached 50% to 69% score “yes”, and Low when the study reached more than 70% score “yes”. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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