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High glucose promotes cell proliferation and enhances GDNF and RET expression in pancreatic cancer cells

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Abstract

Hyperglycemia promotes pancreatic cancer progression, while the underlying mechanism is uncertain. We investigated the cell proliferation, glial cell line-derived neuotrophic factor (GDNF) and its tyrosine kinase receptor RET expression in BxPC-3 and MIA PaCa-2 cells when exposed to different concentrations of glucose. Proliferation of both cells was effected by glucose in a concentration-dependent manner. Definite expression of GDNF and RET was detected in both cells. Glucose concentrations could alter the expression of GDNF and RET in a concentration-dependent manner, correspondingly with the alterations of cell proliferation. Up-regulation of GDNF and RET ligand-receptor interaction might participate in the glucose-induced cancer progression.

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Acknowledgments

This study was supported by grant from National Natural Scientific Foundation on China (2009 No. 30900705) and Scientific Grant of Xi’an City (2009 No. GG06718).

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Authors and Affiliations

  1. Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi’an Jiaotong University, 227 West Yan-ta Road, Xi’an, 710061, China

    Han Liu, Qingyong Ma & Junhui Li

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  1. Han Liu
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  2. Qingyong Ma
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  3. Junhui Li
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Correspondence to Qingyong Ma.

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Liu, H., Ma, Q. & Li, J. High glucose promotes cell proliferation and enhances GDNF and RET expression in pancreatic cancer cells. Mol Cell Biochem 347, 95–101 (2011). https://doi.org/10.1007/s11010-010-0617-0

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