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Taxol from Corylus avellana: paving the way for a new source of this anti-cancer drug

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An Erratum to this article was published on 10 February 2017

Abstract

Taxol is amongst the most effective anti-cancer drugs available in market. The increasing demand of this compound due to its use in treating wide range of cancers, as well as its high cost have triggered efforts to find alternative ways to obtain this drug. Hazel (Corylus avellana), which is already cultivated for nutritional aspects, is now attracting attention for its phytochemical content. Notably the discovery of taxol and related taxanes in this plant species prompted extensive interest to explore biotechnological production of these compounds using in vitro cultures of C. avellana. This review emphasizes the potential of C. avellana cells for production of taxol and related taxanes. The botanical description of C. avellana, its pharmacological uses and various biotechnological approaches, such as micropropagation, cell culture and genetic engineering to increase the production of taxol and related taxanes are discussed. To present an overall overview, the experience of researchers working on these aspects is mentioned and major highlights or discoveries are presented. A review of the literature suggests that C. avellana may act as a commercial and alternative source for taxol production in an eco-friendly way, which will meet the ever-increasing demand, and also help reducing the cost of this anti-cancer compound.

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References

  • Abbasin Z, Zamani S, Movahedi S, Khaksar G, Sayed Tabatabaei BE (2010) In vitro micropropagation of yew (Taxus baccata) and production of plantlets. Biotechnology 9:48–54

    Article  CAS  Google Scholar 

  • Alasalvar C, Shahidi F (2008) Tree nuts: composition, phytochemicals, and health effects. An overview. In: Alasalvar C, Shahidi F (eds) Tree nuts: composition, phytochemicals, and health effects. CRC press, Boca Raton, pp 1–10

    Google Scholar 

  • Alasalvar C, Amaral JS, Shahidi F (2006) Functional lipid characteristics of Turkish Tombul hazelnut (Corylus avellana L.). J Agric Food Chem 54:10177–10183

    Article  CAS  PubMed  Google Scholar 

  • Bacchetta L, Aramini M, Bernardini C (2008) In vitro propagation of traditional Italian hazelnut cultivars as a tool for the valorization and conservation of local genetic resources. Hortic Sci 43(2):562–566

    Google Scholar 

  • Badi HN, Abdoosi V, Farzin N (2015) New approach to improve taxol biosynthetic. Trak J Sci 2:115–124

    Article  Google Scholar 

  • Baebler Š, Hren M, Camloh M et al (2005) Establishment of cell suspension cultures of yew (Taxus × media Rehd.) and assessment of their genomic stability. In Vitro Cell Dev Biol Plant 41:338–343

    Article  CAS  Google Scholar 

  • Bedi YS, Ogra RK, Koul K, Kaul BL, Kapil RS (1993) Yew (Taxus spp). A new look on utilization, cultivation and conservation. In: Handa SS, Kaul MK (eds) Supplement to cultivation and utilization of medicinal plants. Jammu-Tawi: Regional Research Laboratory, Council of Scientific and Industrial Research, New Delhi, pp 443–456

    Google Scholar 

  • Belabbassi O, Khelifi-Slaoui M, Zaoui D, Benyammi R, Khalfallah N, Malik S, Makhzoum A, Khelifi L (2016) Synergistic effects of polyploidization and elicitation on biomass and hyoscyamine content in hairy roots of Datura stramonium. Biotechnol Agron Soc EnviroN 20:3

    Google Scholar 

  • Bemani E, Ghanati F, Yousefzadeh Boroujeni L, Khatami F (2012) Antioxidant activity, total phenolics and taxol contents response of hazel (Corylus avellana L.) cells to benzoic acid and cinnamic Acid. Notulae Botanicae Horti Agrobotanici Cluj-Napoca 40(1):69–73

    CAS  Google Scholar 

  • Bemani E, Ghanati F, Razaei A, Jamshidi M (2013) Effect of phenylalanine on taxol production and antioxidant activity of extracts of suspension-cultured hazel (Corylus avellana L) cells. Nat Med 67:446–451

    Article  CAS  Google Scholar 

  • Benyammi R, Paris C, Khelifi-Slaoui M, Zaoui D, Belabbassi O, Bakiri N, Aci MM, Harfi B, Malik S, Makhzoum A, Desobry S, Khelifi L (2016) Screening and kinetic studies of catharanthine and ajmalicine accumulation and their correlation with growth biomass in Catharanthus roseus hairy roots. Pharm Biol 17:1–11

    Google Scholar 

  • Bestoso F, Ottaggio L, Armirtti A, Balbi A, Damonte G, Degan P, Mazzei M, Cavalli F, Ledda B, Miele M (2006) In vitro cell cultures obtained from different explants of Corylus avellana produce taxol and taxanes. BMC Biotechnol 6:45

    Article  PubMed  PubMed Central  Google Scholar 

  • Bonfill M, Bentebibel S, Moyano E, Palazón J, Cusidó RM, Eibl R, Piñol MT (2007) Paclitaxel and baccatin III production induced by methyljasmonate in free and immobilized cells of Taxus baccata. Biol Plant 51(4):647–652

    Article  CAS  Google Scholar 

  • Bonfill M, Malik S, Mirjalili MH, Goleniowski M, Cusido R, Palazón J (2013) Production and genetic engineering of terpenoids production in plant cell and organ cultures. In: Ramawat K G, Merillon J M, Henry M (eds) Handbook of natural products: phytochemistry, botany. Metabolism Springer-Verlag, Germany, pp 2763–2792

    Google Scholar 

  • Cang S, Ma Y, Chiao J, Liu D (2014) Phenethyl isothiocyanate and paclitaxel synergistically enhanced apoptosis and alpha-tubulin hyperacetylation in breast cancer cells. Exp Hematol Int Soc Cell 3(1):1

    Google Scholar 

  • Caruso M, Colombo AL, Fedeli L, Pavesi A, Quaroni S, Saracchi M, Ventrella G (2000) Isolation of endophytic fungi and actinomycetes taxane producers. Ann Microbiol 50:3–13

    CAS  Google Scholar 

  • Contessa C, Valentini N, Caviglione M, Botta R (2011a) Propagation of Corylus avellana L. by means of semi-hardwood cuttings: rooting and bud retention in four Italian cultivars. Eur J Hortic Sci 76:170–175

  • Contessa C, Valentini N, Botta R (2011b) Decreasing the concentration of IBA or combination with ethylene inhibitors improve bud retention in semi-hardwood cuttings of hazelnut cultivar “Tona Gentile delle Langhe”. Scentia Hortic 131:103–106

  • Cristofori V, Rouphael Y, Rugini E (2010) Collection time, cutting age, IBA and putrescine effets on root formation in Corylus avellana L. cuttings. Sci Hortic 124:189–194

    Article  CAS  Google Scholar 

  • Cusidó RM, Vidal H, Gallego A, Abdoli M, Palazón J (2013) Biotechnological production of taxanes: a molecular approach. In: Torrero DM, Cortés A, Mariño EL (eds) Recent advances in pharmaceutical sciences III. Kerala Transworld Research Network, India, pp 91–107

    Google Scholar 

  • Diaz-Sala C, Rey M, Rodríguez R (1990) In vitro establishment of a cyclonal chain from nodal segments and apicl buds on adult hazel (Corylus avellana L.). Plant Cell Tissue Organ Cult 23:151–157

    CAS  Google Scholar 

  • Diaz-Sala C, Rey M, Rodríguez R (1994) Temporary modification of adult filbert proliferation capacity by sequential subcultures: intensive pruning as a pre-treatment for in vitro reinvigoration. J Horticult Sci 69(4):673–678

    Article  Google Scholar 

  • Diaz-Sala C, Rey M, Boronat A, Besford R, Rodrı´guez R (1995) Variations in the DNA methylation and polypeptide patterns of adult hazel (Corylus avellana L.) associated with sequential in vitro subcultures. Plant Cell Rep 15:218–221

    Article  CAS  PubMed  Google Scholar 

  • Florea AM, Büsselberg D (2011) Cisplatin as an anti-tumor drug: Cellular mechanisms of activity, drug resistance and induced side effects. Cancers 3(1):1351–1371

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Flores-Bustamante ZR, Rivera-Orduña FN, Martínez-Cárdenas A, Flores-Cotera LB (2010) Microbial paclitaxel: advances and perspectives. J Antibiot 63(8):460–467

    Article  CAS  PubMed  Google Scholar 

  • Frense D (2007) Taxanes: perspectives for biotechnological production. Appl Microbiol Biotechnol 73(6):1233–1240

    Article  CAS  PubMed  Google Scholar 

  • Gallego A, Bonfill M, Cusido RM, Pastor M, Palazon J, Moyano E (2015a) Assessing factors that affect the growth of C. avellana cell suspension cultures: a statistical approach. In Vitro Cell Dev Biol Plant. doi:10.1007/s11627-015-9693-x

  • Gallego A, Imseng N, Bonfill M, Cusido RM, Palazon J, Eibl R, Moyano E (2015b) Development of a hazel cell culture-based paclitaxel and baccatin III production process on a benchtop scale. J Biotechnol 195:93–102

  • Gallego A, Jáuregui O, Moyano E, Palazon J, Casals I, Bonfill M (2015c) Optimization of a liquid chromatography-tandem mass spectrometry method for the quantification of traces of taxanes in a Corylus avellana cell suspension medium. RSC Adv 5:17976–17983

  • Gamborg OL, Miller RA, Ojima O (1968) Nutrient requirements of suspension cultures of soybean root cell. Exp Cell Res 50:151–158

    Article  CAS  PubMed  Google Scholar 

  • Garrison W, Dale A, Saxena PK (2013) Improved shoot multiplication and development in hybrid hazelnut nodal cultures by ethylenediamine di-2-hydroxy-phenylacetic acid (Fe-EDDHA). Can J Plant Sci 93(3):511–521

    Article  CAS  Google Scholar 

  • Ghanati F, Safari M, Hajnorouzi A (2015) Partial clarification of signaling pathway of taxanes increase biosynthesis by low intensity ultrasound treatment in hazel (Corylus avellana) cells. S Afr J Bot 96:65–70

    Article  CAS  Google Scholar 

  • Gligorov J, Lotz JP (2004) Preclinical pharmacology of the taxanes: implications of the differences. Oncologist 9(2):3–8

    Article  CAS  PubMed  Google Scholar 

  • GLOBOCAN (2012) International agency for research on cancer. Estimated incidence, mortality and prevalence worldwide in 2012. Lyon: IARC. Available from: http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx. Accessed Jan 2015

  • Hand C, Reed BM (2014) Minor nutrients are critical for the improved growth of Corylus avellana shoot cultures. Plant Cell Tissue Organ Cult 119:427–439

    Article  CAS  Google Scholar 

  • Hand C, Maki S, Reed BM (2014) Modeling optimal mineral nutrition for hazelnut micropropagation. Plant Cell Tissue Organ Cult 119:411–425

    Article  CAS  Google Scholar 

  • Heinig U, Jennewein S (2009) Taxol: a complex diterpenoid natural product with an evolutionary obscure origin. Afr J Biotechnol 8(8):1370–1385

    CAS  Google Scholar 

  • Heinig U, Scholz S, Jennewein S (2013) Getting to the bottom of taxol biosynthesis by fungi. Fungal Divers 60(1):161–170

    Article  Google Scholar 

  • Hoffman A, Shahidi F (2009) Paclitaxel and other taxanes in hazelnut. J Funct Foods 1:33–37

    Article  CAS  Google Scholar 

  • Hoffman A, Khan W, Worapong J, Strobel G, Griffin D, Arbogast B, Borofsky D, Boone RB, Ning L, Zheng P, Daley L (1998) Bioprospecting for taxol angiosperm plant extracts. Spectroscopy 13:22–32

    CAS  Google Scholar 

  • Holton RA, Somoza C, Kim HB, Liang F, Biediger RJ, Boatman PD, Shindo M, Smith CC, Kim S (1994) First total synthesis of taxol. 1. Functionalization of the B ring. J Am Chem Soc 116(4):1597–1598

    Article  CAS  Google Scholar 

  • Jamshidi M, Ghanati F, Rezaei A, Bemani E (2014) Change of antioxidant enzymes activity of hazel (Corylus avellana L.) cells by AgNPs. Cytotechnology. doi:10.1007/s10616-014-9808-y

    PubMed  Google Scholar 

  • Karasawa MMG, Chiancone B, Gianguzzi V, Abdelgalel AM, Botta R, Sartor C, Germanà MA (2016) Gametic embryogenesis through isolated microspore culture in Corylus avellana L. Plant Cell Tissue Organ Cult 124(3):635–647

    Article  Google Scholar 

  • Kasapligil B (1972) A bibliography on Corylus (Betulaceae) with annotations. Ann Rep N Nut Growers Assoc 63:107–162

    Google Scholar 

  • Kolewe ME, Gaurav V, Roberts SC (2008) Pharmaceutically active natural product synthesis and supply via plant cell culture technology. Mol Pharm 5:243–256

    Article  CAS  PubMed  Google Scholar 

  • Kumar R, Sharma N, Malik S, Bhushan S, Sharma UK, Kumari D, Sinha AK, Sharma M, Ahuja PS (2011) Cell suspension culture of Arnebia euchroma (Royle) Johnston: a potential source of naphthoquinone pigments. J Med Plants Res 5(25):6048–6054

    CAS  Google Scholar 

  • Latawa J, Shukla MR, Saxena PK (2016) An efficient temporary immersion system for micropropagation of hybrid hazelnut. Botany 94(1):1–8. doi:10.1139/cjb-2015-0111

    Article  CAS  Google Scholar 

  • Lavelle F, Gueritte-Voegelein F, Guenard D (1993) Taxotere: from yew’s needles to clinical practice. Bull Cancer 80:326–338

    CAS  PubMed  Google Scholar 

  • Linsmaier EM, Skoog F (1965) Organic growth factor requirements of tobacco tissue cultures. Physiol Plant 18:100–127

    Article  CAS  Google Scholar 

  • Liu K, Cang S, Ma Y, Chiao JW (2013) Synergistic effect of paclitaxel and epigenetic agent phenethyl isothiocyanate on growth inhibition, cell cycle arrest and apoptosis in breast cancer cells. Cancer Cell Int 13(1):1

    Article  CAS  Google Scholar 

  • Ludwig-Müller J (2015) Plants and endophytes: equal partners in secondary metabolite production? Biotechnol Lett 37:1325–1334

    Article  PubMed  Google Scholar 

  • Makhzoum A, Petit-Paly G, Pierre BS, Bernards MA (2011) Functional analysis of the DAT gene promoter using transient Catharanthus roseus and stable Nicotiana tabacum transformation systems. Plant Cell Rep 30(7):1173–1182

    Article  CAS  PubMed  Google Scholar 

  • Makhzoum A, Yousefzadi M, Malik S, Gantet P, Tremouillaux-Guiller J (2015) Strigolactone biology: genes, functional genomics, epigenetics and applications. Crit Rev Biotechnol 15:1–12

    Google Scholar 

  • Malik S, Kumar R, Vats SK, Bhushan S, Sharma M, Ahuja PS (2009) Regeneration in Rheum emodi Wall.: a step towards conservation of an endangered medicinal plant species. Eng Life Sci 2:130–134

    Article  Google Scholar 

  • Malik S, Sharma N, Sharma UK, Singh NP, Bushan S, Sharma M, Sinha AK, Ahuja PS (2010a) Qualitative and quantitative analysis of anthraquinone derivatives in rhizomes of tissue culture raised plants of Rheum emodi Wall. J Plant Physiol 167:749–756

  • Malik S, Sharma S, Sharma M, Ahuja PS (2010b) Direct shoot regeneration from intact leaves of Arnebia euchroma (Royle) Johnston using thidiazuron. Cell Biol Int 34(5):537–542

  • Malik S, Bhushan S, Sharma M, Ahuja PS (2011a) Physico-chemical factors influencing the shikonin derivatives production in cell suspension cultures of Arnebia euchroma (Royle) Johnston, a medicinally important plant species. Cell Biol Int 35(2):152–157

  • Malik S, Cusido RM, Mirjalili MH, Moyano E, Palazon J, Bonfill M (2011b) Production of the anticancer drug taxol in Taxus baccata suspension cultures: a review. Process Biochem 46:23–34

  • Malik S, Mirjalili MH, Fett-Neto AG, Mazzafera P, Bonfill M (2013) Living between two worlds: two-phase culture systems for producing plant secondary metabolites. Crit Rev Biotechnol 33(1):1–22

    Article  CAS  PubMed  Google Scholar 

  • Malik S, Biba O, Gruz J, Arroo RRJ, Strnad M (2014a) Biotechnological approaches for producing aryltetralin lignans from Linum species. Phytochem Rev 13:893–913

  • Malik S, Bhushan S, Sharma M, Ahuja PS (2014b) Biotechnological approaches to the production of shikonins: a critical review with recent updates. Crit Rev Biotechnol 16:1–14

  • Malik S, Sharma M, Ahuja PS (2016) An efficient and economic method for in vitro propagation of Arnebia euchroma using liquid culture system. Am J Biotechnol Med Res 1(1):19–25

    Article  Google Scholar 

  • Messeguer J, Mele E (1983) Clonal propagation of Corylus avellana L. in vitro. Atti del convegno internazionale sul Nocciuolo, Avellino, pp 293–295. Accessed 22–24 Sept

    Google Scholar 

  • Miele M, Mumot AM, Zappa A, Romano P, Ottaggio L (2012) Hazel and other sources of paclitaxel and related compounds. Phytochem Rev 11:211–225

    Article  CAS  Google Scholar 

  • Mittelsten Scheid O, Jakovleva L, Afsar K, Maluszynska J, Paszkowski J (1996) A change of ploidy can modify epigenetic silencing. Proc Natl Acad Sci USA 93:7114–7119

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mohammadzedeh M, Fattahi R, Zamani Z, Khub AK (2014) Genetic identity and relationships of hazelnut (Corylus avellana L.) landraces as revealed by morphological characteristics and molecular markers. Sci Hortic 167:17–26

    Article  CAS  Google Scholar 

  • Molnar TJ (2011) Corylus. In: Kole C (ed) Wild crop relatives: genomic and breeding resources, forest trees. Springer-Verlag, Berlin, pp 15–48

    Chapter  Google Scholar 

  • Murashige T, Skoog F (1962) A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol Plant 15:473–497

    Article  CAS  Google Scholar 

  • Nas MN (2003) Inclusion of Polyamines in the medium improves shoot elongation in hazelnut (Corylus avellana L.) micropropagation. Turk J Agric For 28:189–194

    Google Scholar 

  • Nas MN, Read PE (2004) A hypothesis for the development of a defined tissue culture medium of higher plants and micropropagation of hazelnuts. Sci Hortic 101:189–200

    Article  CAS  Google Scholar 

  • Nicolaou KC, Yang Z, Liu JJ, Ueno H, Nantermet PG, Guy RK, Claiborne CF, Renaud J, Couladouros EA, Paulvannan K, Sorenson EJ (1994) Total synthesis of taxol. Nature 367:630–634

    Article  CAS  PubMed  Google Scholar 

  • Nitsch JP, Nitsch C (1969) Haploid plants from pollen grains. Science 163:85–89

    Article  CAS  PubMed  Google Scholar 

  • Ochoa-Villarreal M, Howat S, Hong SM, Jang MO, Jin YW, Lee EK, Loake GJ (2016) Plant cell culture strategies for the production of natural products. BMB Rep 49(3):149–158

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Oliveira I, Sousa A, Morais JS, Ferreira IC, Bento A, Estevinho L, Pereira JA (2008) Chemical composition, and antioxidant and antimicrobial activities of three hazelnut (Corylus avellana L.) cultivars. Food Chem Toxicol 46(5):1801–1807

    Article  CAS  PubMed  Google Scholar 

  • Ottaggio L, Bestoso F, Armirotti A, Balbi A, Mazzei DG, Sancani M, Miele M (2008) Taxanes from shells and leaves of Corylus avellana. J Nat Prod 71:58–60

    Article  CAS  PubMed  Google Scholar 

  • Page M, Landry N (1996) Bacterial mass production of taxanes with Erwinia. US Patent 5(561):055

    Google Scholar 

  • Page M et al (2000) Bacterial mass production of taxanes and paclitaxel. US Patent 6(030):818

    Google Scholar 

  • Pandi M, SenthilKumaran R, Rajapriya P, Yogeswari S, Muthumary J (2013) Taxol, a potential drug for the treatment of cancer. Biores Bull 2(1):1–9

    Google Scholar 

  • Prando MAS, Chiavazza P, Faggio A, Contessa C (2014) Effect of coconut water and growth regulator supplements on in vitro propagation of Corylus avellana L. Sci Hortic 171:91–94

    Article  CAS  Google Scholar 

  • Priyadarshini K, Aparajitha UK (2012) Paclitaxel against cancer: a short review. Med Chem 2:139–141

    Google Scholar 

  • Qaderi A, Omidi M, Etminan A, Oladzad A, Ebrahimi C, Dehghani Mashkani MR, Mehrafarin A (2012) Hazel (Corylus avellana L.) as a new source of taxol and taxanes. J Med Plants 110(41):66–77

    Google Scholar 

  • Qaderi A, Omidi M, Zebarjadi AR, Hajiaghaee R (2013) Over-expression effect of gene enconding 3-hydroxy-3-methylglutaryl-CoA reductase on production of taxol in Iranian hazel (Corylus avellana L.). J Med Plants 12(47):100–110

    CAS  Google Scholar 

  • Qaderi A, Omidi M, Zebarjadi A, Hajiaghaee R (2014) Isolation and characterization of gene encoding 3-hydroxy-3-methylglutaryl-CoA reductase from Iranian hazel (Corylus avellana L.). Int J Biosci 4(5):216–225

    Google Scholar 

  • Radojević Lj, Vujičić R, Nešković M (1975) Embryogenesis in tissue culture of Corylus avellana L. Z Pflanzenphysiol 77:33–41

    Article  Google Scholar 

  • Rahpeyma SA, Moieni A, Javaran MJ (2015) Paclitaxel production is enhanced in suspension-cultured hazel (Corylus avellana L.) cells by using a combination of sugar, precursor, and elicitor. Eng Life Sci 15:234–242

    Article  CAS  Google Scholar 

  • Razaei A, Ghanati F, Behmanesh M, Mokhtari-Dizaji M (2011) Ultrasound-potentiated salicylic acid-induced physiological effects and production of taxol in hazelnut (Corylus avellana L.) cell culture. Ultrasound Med Biol 37:1938–1947

    Article  Google Scholar 

  • Razaei A, Ghanati F, Behmanesh M, Safari M, Sharafi Y (2013) Synergistic accumulative effect of salicylic acid and dibutyl phthalate on paclitaxel production in Corylus avellana cel culture. J Stress Physiol Biochem 9:157–168

    Google Scholar 

  • Rey M, Tiburcio AF, Diaz-Sala C, Rodríguez R (1994a) Endogenous polyamine concentration in juvenile, adult and in vitro reinvigorated hazel. Tree Physiol 14:191–200

  • Rey M, Díaz-Sala C, Rodríguez R (1994b) Exogenous polyamines improve rooting of hazel microshoots. Plant Cell Tissue Organ Cult 36:303–308

  • Rodríguez R, Sánchez-Tamés R, Durzan DJ (1990) Plant ageing. Basic and applied approaches. Plenum Press, New York, ISBN 978-1-4684-5760-5

    Book  Google Scholar 

  • Rowley ER, Fox SE, Bryant DW, Sullivan CM, Priest HD, Givan SA, Mehlenbacher SA, Mockler TC (2012) Assembly and characterization of the European hazelnut ‘Jefferson’transcriptome”. Crop Sci 52(6):2679–2686

    Article  CAS  Google Scholar 

  • Safari M, Ghanati F, Hajnoruzi A, Razaei A, Abdolmaleki P, Morkhtari-Diazaji M (2012) Mantenance of membrane integrity and increase of taxanes production in hazel (Corylus avellana L.) cells induced by low-intensity ultrasounds. Biotechnol Lett 34:1137–1141

    Article  CAS  PubMed  Google Scholar 

  • Schiff PB, Horwitz SB (1980) Taxol stabilizes microtubules in mouse fibroblast cells. Proc Natl Acad Sci USA 77:1561–1565

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Stanton RA, Gernert KM, Nettles JH, Aneja R (2011) Drugs that target dynamic microtubules: a new molecular perspective. Med Res Rev 31(3):443–481

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Stierle A, Strobel G, Stierle D (1993) Taxol and taxane production by Taxomyces andreanae, and endophytic fungus of pacific yew. Science 260:214–216

    Article  CAS  PubMed  Google Scholar 

  • Thompson MM, Lagerstedt HB, Mehlenbacher SA (1996) Hazelnuts. In: Janick J, Moore JN (eds) Fruit breeding, vol 3. Nuts. Wiley, New York, pp 125–184

    Google Scholar 

  • Tremouillaux GJ (2013) Hairy root culture: an alternative terpenoid exoression platform. In: Ramawat KG, Mérillon JM (eds) Natural products. Springer Verlag, Berlin, pp 2941–2970

    Chapter  Google Scholar 

  • Wang Y, Guo B, Zhang F, Yao H, Miao Z, Tang K (2007) Molecular cloning and functional analysis of the gene enconding 3-hydroxy-3-methylglutaryl coenzyme A reductase from hazelnut hazel (Corylus avellana L. Gasaway). J Biochem Mol Biol 40:861–869

    CAS  PubMed  Google Scholar 

  • Wang Y, Miao Z, Tang K (2009) Molecular cloning and functional expression analysis of a new gene encoding geranylgeranyl diphosphate synthase from hazel (Corylus avellana L. Gasaway). Mol Biol Rep 37:3439–3444

    Article  PubMed  Google Scholar 

  • Wang YF, Shi QW, Dong M, Kiyota H, Gu YC, Cong B (2011) Natural taxanes: developments since 1828. Chem Rev 111(7):652–709

    Google Scholar 

  • Wani MC, Taylor HL, Wall ME, Coggon P, McPhail AT (1971) Plant antitumor agents. VI. The isolation and structure of Taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J Am Chem Soc 93:2325–2327

    Article  CAS  PubMed  Google Scholar 

  • Wheeler NC, Keith J, Masters S, Brobst SW, Alvarado AB, Hoover AJ, Snader KM (1992) Effects of genetic, epigenetic, and environmental factors on taxol content inTaxus brevifolia and related species. J Nat Prod 55(4):432–440

    Article  CAS  PubMed  Google Scholar 

  • Yu X, Reed BM (1993) Improved shoot multiplication of mature hazelnut (Corylus avellana L.) in vitro using glucose as a carbon source. Plant Cell Rep 12:256–259

    Article  CAS  PubMed  Google Scholar 

  • Yu X, Reed BM (1995) A micropropagation system for hazelnuts (Corylus species). Hortic Sci 30(1):120–123

    Google Scholar 

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Acknowledgements

SM would like to acknowledge the Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Estado do Maranhão – FAPEMA, Brazil for financial support.

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An erratum to this article is available at http://dx.doi.org/10.1007/s11240-017-1175-x.

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Gallego, A., Malik, S., Yousefzadi, M. et al. Taxol from Corylus avellana: paving the way for a new source of this anti-cancer drug. Plant Cell Tiss Organ Cult 129, 1–16 (2017). https://doi.org/10.1007/s11240-016-1164-5

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