European Journal of Cancer and Clinical Oncology
Endocrine and immune effects of melatonin therapy in metastatic cancer patients
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Molecular basis of melatonin protective effects in metastasis: A novel target of melatonin
2022, BiochimieCitation Excerpt :As reported by Lissoni et al. [63] administering MLT with IL-2 enhances the survival rate “due to a modulation of macrophage-mediated suppressive events which occur during IL-2 immunotherapy”. In two different studies, Lissoni and colleagues demonstrated that MLT increases the survival time in lung carcinoma patients with bone, soft tissue, and liver metastasis [63,64]. In 2019, an in vivo study also demonstrated the inhibitory effect of MLT on liver metastasis [42].
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Melatonin as a multifunctional anti-cancer molecule: Implications in gastric cancer
2017, Life SciencesCitation Excerpt :Moreover, disease control and tumor regression was achieved in some cases. These results prompted further evaluation of melatonin in cancer in the clinical setting [105]. In a subsequent study on patients suffering from metastatic non-small cell lung cancer (NSCLC) unresponsive to first-line chemotherapy, treatment with MT significantly increased 1-year survival and disease stabilization with an additional improvement of performance [106].
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Physiological melatonin levels in healthy older people: A systematic review
2016, Journal of Psychosomatic ResearchCitation Excerpt :In diverse conditions alterations in melatonin concentrations have been described. Bartsch, Lissoni and Mazzoccoli [5–10] investigated melatonin concentrations in breast, lung and prostate cancer patients and compared the levels in different stages of disease. They found a relationship between the stage of disease and the peak melatonin concentration, which decreased in advanced cancer, and appeared to be lower than in healthy persons.
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The melatonin-producing system is fully functional in retinal pigment epithelium (ARPE-19)
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Melatonin receptors in humans: Biological role and clinical relevance
2006, Biomedicine and PharmacotherapyCitation Excerpt :Furthermore, melatonin activates human monocytes by inducing cellular cytotoxic agents, such as interleukins and TNF-α [125]. In clinical trials carried out in metastatic cancer patients, melatonin and IL-1 were found to increase the CD4/CD8 ratio [126]. The mechanisms of melatonin action on the immune system include: