RESEARCH ARTICLE
Clinical Investigation: Determinants of Blood Cell Omega-3 Fatty Acid Content
Robert C. Blocka, *, William S. Harris b, James V. Pottala b
Article Information
Identifiers and Pagination:
Year: 2008Volume: 1
First Page: 1
Last Page: 6
Publisher ID: TOBIOMJ-1-1
DOI: 10.2174/1875318300801010001
Article History:
Received Date: 24/03/2008Revision Received Date: 28/04/2008
Acceptance Date: 13/06/2008
Electronic publication date: 29/08/2008
Collection year: 2008
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Background:
Although red blood cell eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) content (the Omega-3 Index) predicts cardiovascular death, the factors determining the Index are unknown.
Methods:
In 704 outpatients, we undertook an investigation of the clinical determinants of the Index.
Results:
Factors associated with the Index in decreasing order were: EPA+DHA supplement use, fish consumption frequency, triglyceride level, age, high cholesterol history, and smoking. These factors explained 59% of Index variability, with capsules/fish intake together accounting for 47%. The Index increased by 13% (p< 0.0001) for each serving level increase in fish intake and EPA+DHA supplementation correlated with a 58% increase (p< 0.0001) regardless of background fish intake (p=0.25; test for interaction). A 100 mg/dL decrease in serum triglycerides was associated with a 15% higher (p<0.0001) Index.
Conclusions:
The intake of EPA+DHA-rich foods and supplements principally determined the Omega-3 Index, but explained only about half of the variability.