Ascorbic Acid-Induced Hemolysis in G-6-PD Deficiency
Publication: Annals of Internal Medicine
Volume 82, Number 6
Excerpt
Though the origins of erythrocyte glucose-6-phosphate dehydrogenase (G-6-PD) deficiency are rooted in human antiquity, the presence of drug-induced hemolysis in individuals subsequently felt to have G-6-PD deficiency was first reported in 1926 and the biochemical lesion responsible for this phenomenon elucidated in 1956 (1). In the United States, hemolysis induced by infection or drugs is the most common clinical manifestation of G-6-PD deficiency (2).
Ascorbic acid (vitamin C), an essential vitamin, is commonly used in pharmacologic doses for the prevention of the common cold and to promote the healing of wounds. We report here an individual with G-6-PD deficiency who...
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References
1.
BEUTLER E: The hemolytic effect of primaquine and related compounds: a review. Blood 14:103-138, 1959
2.
BEUTLER E: Abnormalities of the hexose monophosphate shunt. Semin Hematol 8:311-347, 1971
3.
STEINBERG M and DREILING B: Glucose-6-phosphate dehydrogenase deficiency in sickle-cell anemia: a study in adults. Ann Intern Med 80:217-220, 1974
4.
SCHWARTZ A, TOGO Y, and HORNICK R: Evaluation of the efficacy of ascorbic acid in prophylaxis of induced rhinovirus 44 infection in man. J Infect Dis 128:500-505, 1973
5.
BREWER G, TARLOV A, and ALVING A: Standardization of procedures for the study of glucose-6-phosphate dehydrogenase. WHO Tech Rep Ser No. 366, 1967, p. 27
Information & Authors
Information
Published In
Annals of Internal Medicine
Volume 82 • Number 6 • 1 June 1975
Pages: 810
History
Published in issue: 1 June 1975
Published online: 1 December 2008
Keywords
- Anemia
- Biochemistry
- Dehydrogenases
- Diagnostic medicine
- Drugs
- Enzymes
- Enzymology
- Hematology and oncology
- Hemolytic anemia
- Hospital medicine
- Lesions
- Nutrition
- Pharmacology
- Prevention, policy, and public health
- Pulmonary diseases
- Research and reporting methods
- Respiratory infections
- Signs and symptoms
- Upper respiratory tract infections
- Vitamins
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Ascorbic Acid-Induced Hemolysis in G-6-PD Deficiency. Ann Intern Med.1975;82:810-810. doi:10.7326/0003-4819-82-6-810_1
Ascorbic Acid-Induced Hemolysis in G-6-PD Deficiency. Ann Intern Med.1975;82:810-810. doi:10.7326/0003-4819-82-6-810_1
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