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Metabolomics Reveals that Dietary Ferulic Acid and Quercetin Modulate Metabolic Homeostasis in Rats

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† CAS Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Centre for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences (CAS), Wuhan 430071, China
‡ State Key Laboratory of Genetic Engineering, Collaborative Innovation Centre for Genetics and Development, Shanghai International Centre for Molecular Phenomics, Zhongshan Hospital, School of Life Sciences, Fudan University, Shanghai 200433, PR China
§ School of Environmental and Safety Engineering, Changzhou University, Jiangsu 213164, China
ζ Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou 310058, PR China
*E-mail: [email protected]. Telephone: +86-27-87198430. Fax: +86-27-87199291 (L.Z.).
*E-mail: [email protected]. Telephone: +86-27-87197104. Fax: +86-27-87199291 (H.T.).
*E-mail: [email protected]. Telephone: +86-27-87197143. Fax: +86-27-87199291 (Y.W.).
Cite this: J. Agric. Food Chem. 2018, 66, 7, 1723–1731
Publication Date (Web):January 23, 2018
https://doi.org/10.1021/acs.jafc.8b00054
Copyright © 2018 American Chemical Society
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    Abstract

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    Phenolic compounds ingestion has been shown to have potential preventive and therapeutic effects against various metabolic diseases such as obesity and cancer. To provide a better understanding of these potential benefit effects, we investigated the metabolic alterations in urine and feces of rat ingested ferulic acid (FA) and quercetin (Qu) using NMR-based metabolomics approach. Our results suggested that dietary FA and/or Qu significantly decreased short chain fatty acids and elevated oligosaccharides in the feces, implying that dietary FA and Qu may modulate gut microbial community with inhibition of bacterial fermentation of dietary fibers. We also found that dietary FA and/or Qu regulated several host metabolic pathways including TCA cycle and energy metabolism, bile acid, amino acid, and nucleic acid metabolism. These biological effects suggest that FA and Qu display outstanding bioavailability and bioactivity and could be used for treatment of some metabolic syndromes, such as inflammatory bowel diseases and obesity.

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.jafc.8b00054.

    • Table S1, ,etabolites assignment in urine and fecal extracts; Table S2, significantly changed metabolites in urine of rats after FA and Qu consumption in comparison with controls; Table S3, significantly changed metabolites in feces of rats after FA and Qu consumption in comparison with controls (PDF)

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