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Direct Binding of Bcl-2 Family Proteins by Quercetin Triggers Its Pro-Apoptotic Activity

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† § Section of Organic Chemistry and Biochemistry, Department of Chemistry, Laboratory of Biological Chemistry, School of Medicine, §Cancer Biobank Center, and Department of Hematology, School of Medicine, Laboratory of Biology, School of Medicine, University of Ioannina, 45110 Ioannina, Greece
# Foundation of Research and Technology−Hellas, Institute of Molecular Biology and Biotechnology, Division of Biomedical Research, University Campus, 45110 Ioannina, Greece
Medical Proteomics Research Center, KRIBB, Daejeon 305-806, Republic of Korea
*Phone: +302651008389. Fax: +302651008729. Email: [email protected]
*Phone: +30265108387. Email: [email protected]
Cite this: ACS Chem. Biol. 2014, 9, 12, 2737–2741
Publication Date (Web):September 11, 2014
https://doi.org/10.1021/cb500259e
Copyright © 2014 American Chemical Society

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    Abstract

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    Bcl-2 family proteins are important regulators of apoptosis and its antiapoptotic members, which are overexpressed in many types of cancer, are of high prognostic significance, establishing them as attractive therapeutic targets. Quercetin, a natural flavonoid, has drawn much attention because it exerts anticancer effects, while sparing normal cells. A multidisciplinary approach has been employed herein, in an effort to reveal its mode of action including dose–response antiproliferative activity and induced apoptosis effect, biochemical and physicochemical assays, and computational calculations. It may be concluded that, quercetin binds directly to the BH3 domain of Bcl-2 and Bcl-xL proteins, thereby inhibiting their activity and promoting cancer cell apoptosis.

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    Chemical structures, graphs for of flow cytometric and Western blot analysis of apoptosis evaluation, NMR chemical shift perturbations, the in vitro pull down assay protocol as also the different fluorimetry assays are available free of charge via the Internet at http://pubs.acs.org.

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