Calorie Restriction as an Anti-Invasive Therapy for Malignant Brain Cancer in the VM Mouse
Abstract
INTRODUCTION
MATERIALS AND METHODS
Mice
Tumour formation
Transduction of cell lines
Tumour implantation
Imaging
Dietary regimens, body weight and food intake measurements
Plasma glucose measurements
Ketone determination
Histology
Immunohistochemical staining
RESULTS
Effect of calorie restriction on body weights, and plasma glucose and ketones
Effect of calorie restriction on tumour growth and invasion
DISCUSSION
Abbreviations
- AL
- ad libitum
- CR
- ad libitum
- GBM
- glioblastoma multiforme
- H & E
- haematoxylin and eosin
- i.c.
- intracerebrally
- IGF-1
- insulin-like growth factor 1
- VM-M3
- mouse malignant glioma
- VM-M3/Fluc
- VM-M3 cells labelled with firefly luciferase
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