Supplementation of the Pure Flavonoids Epicatechin and Quercetin Affects Some Biomarkers of Endothelial Dysfunction and Inflammation in (Pre)Hypertensive Adults: A Randomized Double-Blind, Placebo-Controlled, Crossover Trial1,2
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Keywords
atherosclerosis
CVD
endothelial dysfunction
inflammation
epicatechin
quercetin
flavonoids
clinical trial
Abbreviations
CRP
C-reactive protein
CVD
cardiovascular disease
FMD
flow-mediated dilation
MCP-1
monocyte chemotactic protein-1
SAA
serum amyloid A
sE-selectin
soluble endothelial selectin
sICAM-1
soluble intercellular adhesion molecule-1
sVCAM-1
soluble vascular adhesion molecule
vWf
von Willebrand factor
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Supported by Top Institute Food and Nutrition (TIFN) (JID, JMG, and PCH), a public-private partnership on pre-competitive research in food and nutrition. TIFN had no role in the study design, data acquisition and analysis or drafting of the manuscript, or decision to publish.
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Author disclosures: JI Dower, JM Geleijnse, L Gijsbers, C Schalkwijk, D Kromhout, and PC Hollman, no conflicts of interest.
Copyright © 2015 American Society of Nutrition. Published by Elsevier Inc. All rights reserved.