Antitumor and antimetastatic activity of fucoidan, a sulfated polysaccharide isolated from the Okhotsk Sea Fucus evanescens brown alga
Bull Exp Biol Med. 2007 Jun;143(6):730-2. doi: 10.1007/s10517-007-0226-4.
[Article in English, Russian]
Affiliation
- 1 Institute of Physiology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk.
Abstract
Antitumor and antimetastatic activities of fucoidan, a sulfated polysaccharide isolated from Fucus evanescens (brown alga in Okhotsk sea), was studied in C57Bl/6 mice with transplanted Lewis lung adenocarcinoma. Fucoidan after single and repeated administration in a dose of 10 mg/kg produced moderate antitumor and antimetastatic effects and potentiated the antimetastatic, but not antitumor activities of cyclophosphamide. Fucoidan in a dose of 25 mg/kg potentiated the toxic effect of cyclophosphamide.
Publication types
- Research Support, Non-U.S. Gov't
MeSH terms
- Animals
- Antineoplastic Agents, Phytogenic / therapeutic use*
- Cathepsin B / metabolism
- Cathepsin D / metabolism
- Cathepsin L
- Cathepsins / metabolism
- Cyclophosphamide / therapeutic use
- Cysteine Endopeptidases / metabolism
- Drug Synergism
- Fucus / chemistry
- Lung Neoplasms / secondary
- Mice
- Mice, Inbred C57BL
- Neoplasm Metastasis / drug therapy*
- Neoplasm Transplantation
- Neoplasms, Experimental / enzymology
- Polysaccharides / therapeutic use*
- Sulfuric Acid Esters / therapeutic use
Substances
- Antineoplastic Agents, Phytogenic
- Polysaccharides
- Sulfuric Acid Esters
- Cyclophosphamide
- fucoidan
- Cathepsins
- Cysteine Endopeptidases
- Cathepsin B
- Cathepsin L
- Ctsl protein, mouse
- Cathepsin D