Inhibition of Human Telomerase by a G-Quadruplex-Interactive Compound

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16. Fernaldo Richtia Winnerdy, Poulomi Das, Brahim Heddi, Anh Tuân Phan. Solution Structures of a G-Quadruplex Bound to Linear- and Cyclic-Dinucleotides. Journal of the American Chemical Society 2019, 141 (45) , 18038-18047. https://doi.org/10.1021/jacs.9b05642
17. Paulami Mandal, Dibakar Sahoo, Saumen Saha, Joydeep Chowdhury. Sensing of Different Human Telomeric G-Quadruplex DNA Topologies by Natural Alkaloid Allocryptopine Using Spectroscopic Techniques. The Journal of Physical Chemistry B 2018, 122 (45) , 10279-10290. https://doi.org/10.1021/acs.jpcb.8b07856
18. Heiko Ihmels, Siyu Jiang, Mohamed M. A. Mahmoud, Holger Schönherr, Daniel Wesner, Imad Zamrik. Fluorimetric Detection of G-Quadruplex DNA in Solution and Adsorbed on Surfaces with a Selective Trinuclear Cyanine Dye. Langmuir 2018, 34 (39) , 11866-11877. https://doi.org/10.1021/acs.langmuir.8b02382
19. Sneha Paul and Anunay Samanta . Ground- and Excited-State Interactions of a Psoralen Derivative with Human Telomeric G-Quadruplex DNA. The Journal of Physical Chemistry B 2018, 122 (8) , 2277-2286. https://doi.org/10.1021/acs.jpcb.7b12475
20. Alicia J. Angelbello, Jonathan L. Chen, Jessica L. Childs-Disney, Peiyuan Zhang, Zi-Fu Wang, and Matthew D. Disney . Using Genome Sequence to Enable the Design of Medicines and Chemical Probes. Chemical Reviews 2018, 118 (4) , 1599-1663. https://doi.org/10.1021/acs.chemrev.7b00504
21. Jibin Abraham Punnoose, Yue Ma, Yuanyuan Li, Mai Sakuma, Shankar Mandal, Kazuo Nagasawa, and Hanbin Mao . Adaptive and Specific Recognition of Telomeric G-Quadruplexes via Polyvalency Induced Unstacking of Binding Units. Journal of the American Chemical Society 2017, 139 (22) , 7476-7484. https://doi.org/10.1021/jacs.7b00607
22. Stephen Neidle . Quadruplex Nucleic Acids as Novel Therapeutic Targets. Journal of Medicinal Chemistry 2016, 59 (13) , 5987-6011. https://doi.org/10.1021/acs.jmedchem.5b01835
23. Di Luo and Yuguang Mu . Computational Insights into the Stability and Folding Pathways of Human Telomeric DNA G-Quadruplexes. The Journal of Physical Chemistry B 2016, 120 (22) , 4912-4926. https://doi.org/10.1021/acs.jpcb.6b01919
24. Susanna Cogoi, Sonia Zorzet, Andrey E. Shchekotikhin, and Luigi E. Xodo . Potent Apoptotic Response Induced by Chloroacetamidine Anthrathiophenediones in Bladder Cancer Cells. Journal of Medicinal Chemistry 2015, 58 (14) , 5476-5485. https://doi.org/10.1021/acs.jmedchem.5b00409
25. Angelica Mariani, Alexandra Bartoli, Mandeep Atwal, Ka C. Lee, Caroline A. Austin, and Raphaël Rodriguez . Differential Targeting of Human Topoisomerase II Isoforms with Small Molecules. Journal of Medicinal Chemistry 2015, 58 (11) , 4851-4856. https://doi.org/10.1021/acs.jmedchem.5b00473
26. Di Luo and Yuguang Mu . All-Atomic Simulations on Human Telomeric G-Quadruplex DNA Binding with Thioflavin T. The Journal of Physical Chemistry B 2015, 119 (15) , 4955-4967. https://doi.org/10.1021/acs.jpcb.5b01107
27. Zhen-Feng Chen, Qi-Pin Qin, Jiao-Lan Qin, Yan-Cheng Liu, Ke-Bin Huang, Yu-Lan Li, Ting Meng, Guo-Hai Zhang, Yan Peng, Xu-Jian Luo, and Hong Liang . Stabilization of G-Quadruplex DNA, Inhibition of Telomerase Activity, and Tumor Cell Apoptosis by Organoplatinum(II) Complexes with Oxoisoaporphine. Journal of Medicinal Chemistry 2015, 58 (5) , 2159-2179. https://doi.org/10.1021/jm5012484
28. Laureline Lecarme, Enora Prado, Aurore De Rache, Marie-Laure Nicolau-Travers, Romaric Bonnet, Angeline van Der Heyden, Christian Philouze, Dennis Gomez, Jean-Louis Mergny, Hélène Jamet, Eric Defrancq, Olivier Jarjayes, and Fabrice Thomas . Interaction of Polycationic Ni(II)-Salophen Complexes with G-Quadruplex DNA. Inorganic Chemistry 2014, 53 (23) , 12519-12531. https://doi.org/10.1021/ic502063r
29. Vivek Kumar, Abhigyan Sengupta, Krishna Gavvala, Raj Kumar Koninti, and Partha Hazra . Spectroscopic and Thermodynamic Insights into the Interaction between Proflavine and Human Telomeric G-Quadruplex DNA. The Journal of Physical Chemistry B 2014, 118 (38) , 11090-11099. https://doi.org/10.1021/jp506267b
30. Xiaojie Cui, Qiang Zhang, Han Chen, Jiang Zhou, Gu Yuan. ESI Mass Spectrometric Exploration of Selective Recognition of G-Quadruplex in c-myb Oncogene Promoter Using a Novel Flexible Cyclic Polyamide. Journal of the American Society for Mass Spectrometry 2014, 25 (4) , 684-691. https://doi.org/10.1007/s13361-013-0802-y
31. Vijay Sekaran, Joana Soares, and Michael B. Jarstfer . Telomere Maintenance as a Target for Drug Discovery. Journal of Medicinal Chemistry 2014, 57 (3) , 521-538. https://doi.org/10.1021/jm400528t
32. Grant A. L. Bare, Bo Liu, and John C. Sherman . Synthesis of a Single G-Quartet Platform in Water. Journal of the American Chemical Society 2013, 135 (32) , 11985-11989. https://doi.org/10.1021/ja405100z
33. Marialuisa Micco, Gavin W. Collie, Aaron G. Dale, Stephan A. Ohnmacht, Ingrida Pazitna, Mekala Gunaratnam, Anthony P. Reszka, and Stephen Neidle . Structure-Based Design and Evaluation of Naphthalene Diimide G-Quadruplex Ligands As Telomere Targeting Agents in Pancreatic Cancer Cells. Journal of Medicinal Chemistry 2013, 56 (7) , 2959-2974. https://doi.org/10.1021/jm301899y
34. Susanna Cogoi, Andrey E. Shchekotikhin, Alexandro Membrino, Yuri B. Sinkevich, and Luigi E. Xodo . Guanidino Anthrathiophenediones as G-Quadruplex Binders: Uptake, Intracellular Localization, and Anti-Harvey-ras Gene Activity in Bladder Cancer Cells. Journal of Medicinal Chemistry 2013, 56 (7) , 2764-2778. https://doi.org/10.1021/jm3019063
35. Vineeth Thachappilly Mukundan and Anh Tuân Phan . Bulges in G-Quadruplexes: Broadening the Definition of G-Quadruplex-Forming Sequences. Journal of the American Chemical Society 2013, 135 (13) , 5017-5028. https://doi.org/10.1021/ja310251r
36. Sathyanarayana R. Perumalla, Venkateswara R. Pedireddi, and Changquan C. Sun . Protonation of Cytosine: Cytosinium vs Hemicytosinium Duplexes. Crystal Growth & Design 2013, 13 (2) , 429-432. https://doi.org/10.1021/cg3014915
37. Romain Haudecoeur, Loic Stefan, Franck Denat, and David Monchaud . A Model of Smart G-Quadruplex Ligand. Journal of the American Chemical Society 2013, 135 (2) , 550-553. https://doi.org/10.1021/ja310056y
38. Qiang Zhang, Xiaojie Cui, Sen Lin, Jiang Zhou, and Gu Yuan . Convenient Method for the Synthesis of a Flexible Cyclic Polyamide for Selective Targeting of c-myb G-quadruplex DNA. Organic Letters 2012, 14 (24) , 6126-6129. https://doi.org/10.1021/ol302918f
39. Sarah E. Altschuler, Johnny E. Croy, and Deborah S. Wuttke . A Small Molecule Inhibitor of Pot1 Binding to Telomeric DNA. Biochemistry 2012, 51 (40) , 7833-7845. https://doi.org/10.1021/bi300365k
40. Yi Long, Zeng Li, Jia-Heng Tan, Tian-Miao Ou, Ding Li, Lian-Quan Gu, and Zhi-shu Huang . Benzofuroquinoline Derivatives Had Remarkable Improvement of their Selectivity for Telomeric G-Quadruplex DNA over Duplex DNA upon Introduction of Peptidyl Group. Bioconjugate Chemistry 2012, 23 (9) , 1821-1831. https://doi.org/10.1021/bc300123m
41. Matjaž Bončina, Jurij Lah, Iztok Prislan, and Gorazd Vesnaver . Energetic Basis of Human Telomeric DNA Folding into G-Quadruplex Structures. Journal of the American Chemical Society 2012, 134 (23) , 9657-9663. https://doi.org/10.1021/ja300605n
42. Gavin W. Collie, Rossella Promontorio, Sonja M. Hampel, Marialuisa Micco, Stephen Neidle, and Gary N. Parkinson . Structural Basis for Telomeric G-Quadruplex Targeting by Naphthalene Diimide Ligands. Journal of the American Chemical Society 2012, 134 (5) , 2723-2731. https://doi.org/10.1021/ja2102423
43. Nancy H. Campbell, Nurul H. Abd Karim, Gary N. Parkinson, Mekala Gunaratnam, Vanessa Petrucci, Alan K. Todd, Ramon Vilar, and Stephen Neidle . Molecular Basis of Structure–Activity Relationships between Salphen Metal Complexes and Human Telomeric DNA Quadruplexes. Journal of Medicinal Chemistry 2012, 55 (1) , 209-222. https://doi.org/10.1021/jm201140v
44. V. Dhamodharan, S. Harikrishna, C. Jagadeeswaran, K. Halder, and P. I. Pradeepkumar . Selective G-quadruplex DNA Stabilizing Agents Based on Bisquinolinium and Bispyridinium Derivatives of 1,8-Naphthyridine. The Journal of Organic Chemistry 2012, 77 (1) , 229-242. https://doi.org/10.1021/jo201816g
45. Hongjuan Xi, Erik Davis, Nihar Ranjan, Liang Xue, David Hyde-Volpe, and Dev P. Arya . Thermodynamics of Nucleic Acid “Shape Readout” by an Aminosugar. Biochemistry 2011, 50 (42) , 9088-9113. https://doi.org/10.1021/bi201077h
46. Ilse Manet, Francesco Manoli, Maria Pia Donzello, Claudio Ercolani, Daniela Vittori, Luciano Cellai, Annalisa Masi, and Sandra Monti . Tetra-2,3-pyrazinoporphyrazines with Externally Appended Pyridine Rings. 10. A Water-Soluble Bimetallic (ZnII/PtII) Porphyrazine Hexacation as Potential Plurimodal Agent for Cancer Therapy: Exploring the Behavior as Ligand of Telomeric DNA G-Quadruplex Structures. Inorganic Chemistry 2011, 50 (16) , 7403-7411. https://doi.org/10.1021/ic200514z
47. Brahim Heddi and Anh Tuân Phan . Structure of Human Telomeric DNA in Crowded Solution. Journal of the American Chemical Society 2011, 133 (25) , 9824-9833. https://doi.org/10.1021/ja200786q
48. Liang Xue, Nihar Ranjan, and Dev P. Arya . Synthesis and Spectroscopic Studies of the Aminoglycoside (Neomycin)−Perylene Conjugate Binding to Human Telomeric DNA. Biochemistry 2011, 50 (14) , 2838-2849. https://doi.org/10.1021/bi1017304
49. Gavin W. Collie, Silvia Sparapani, Gary N. Parkinson, and Stephen Neidle . Structural Basis of Telomeric RNA Quadruplex−Acridine Ligand Recognition. Journal of the American Chemical Society 2011, 133 (8) , 2721-2728. https://doi.org/10.1021/ja109767y
50. Ke-wei Zheng, Dan Zhang, Li-xia Zhang, Yu-hua Hao, Xiang Zhou, and Zheng Tan . Dissecting the Strand Folding Orientation and Formation of G-Quadruplexes in Single- and Double-Stranded Nucleic Acids by Ligand-Induced Photocleavage Footprinting. Journal of the American Chemical Society 2011, 133 (5) , 1475-1483. https://doi.org/10.1021/ja108972e
51. Nihar Ranjan, Katrine F. Andreasen, Sunil Kumar, David Hyde-Volpe, and Dev P. Arya. Aminoglycoside Binding to Oxytricha nova Telomeric DNA. Biochemistry 2010, 49 (45) , 9891-9903. https://doi.org/10.1021/bi101517e
52. Tani Agarwal, Saumya Roy, Tushar Kanti Chakraborty, and Souvik Maiti . Selective Targeting of G-Quadruplex Using Furan-Based Cyclic Homooligopeptides: Effect on c-MYC Expression. Biochemistry 2010, 49 (38) , 8388-8397. https://doi.org/10.1021/bi1005927
53. Kogularamanan Suntharalingam, Andrew J. P. White, and Ramon Vilar. Two Metals Are Better than One: Investigations on the Interactions between Dinuclear Metal Complexes and Quadruplex DNA. Inorganic Chemistry 2010, 49 (18) , 8371-8380. https://doi.org/10.1021/ic100884p
54. Silvia Sparapani, Shozeb M. Haider, Filippo Doria, Mekala Gunaratnam and Stephen Neidle. Rational Design of Acridine-Based Ligands with Selectivity for Human Telomeric Quadruplexes. Journal of the American Chemical Society 2010, 132 (35) , 12263-12272. https://doi.org/10.1021/ja1003944
55. Kah Wai Lim, Laurent Lacroix, Doris Jia En Yue, Joefina Kim Cheow Lim, Jocelyn Mei Wen Lim and Anh Tuân Phan . Coexistence of Two Distinct G-Quadruplex Conformations in the hTERT Promoter. Journal of the American Chemical Society 2010, 132 (35) , 12331-12342. https://doi.org/10.1021/ja101252n
56. Suzanne G. Rzuczek, Daniel S. Pilch, Angela Liu, Leroy Liu, Edmond J. LaVoie and Joseph E. Rice . Macrocyclic Pyridyl Polyoxazoles: Selective RNA and DNA G-Quadruplex Ligands as Antitumor Agents. Journal of Medicinal Chemistry 2010, 53 (9) , 3632-3644. https://doi.org/10.1021/jm1000612
57. Robert Hänsel, Silvie Foldynová-Trantírková, Frank Löhr, Janina Buck, Eva Bongartz, Ernst Bamberg, Harald Schwalbe, Volker Dötsch and Lukáš Trantírek . Evaluation of Parameters Critical for Observing Nucleic Acids Inside Living Xenopus laevis Oocytes by In-Cell NMR Spectroscopy. Journal of the American Chemical Society 2009, 131 (43) , 15761-15768. https://doi.org/10.1021/ja9052027
58. Amritraj Patra and Clemens Richert . High Fidelity Base Pairing at the 3′-Terminus. Journal of the American Chemical Society 2009, 131 (35) , 12671-12681. https://doi.org/10.1021/ja9033654
59. SunMi L. Palumbo, Scot W. Ebbinghaus and Laurence H. Hurley . Formation of a Unique End-to-End Stacked Pair of G-Quadruplexes in the hTERT Core Promoter with Implications for Inhibition of Telomerase by G-Quadruplex-Interactive Ligands. Journal of the American Chemical Society 2009, 131 (31) , 10878-10891. https://doi.org/10.1021/ja902281d
60. Amit Arora and Souvik Maiti. Stability and Molecular Recognition of Quadruplexes with Different Loop Length in the Absence and Presence of Molecular Crowding Agents. The Journal of Physical Chemistry B 2009, 113 (25) , 8784-8792. https://doi.org/10.1021/jp809486g
61. Jason S. Hudson, Sonja C. Brooks and David E. Graves . Interactions of Actinomycin D with Human Telomeric G-Quadruplex DNA. Biochemistry 2009, 48 (21) , 4440-4447. https://doi.org/10.1021/bi900203z
62. Vishal P. Zambre, Prashant R. Murumkar, Rajani Giridhar and Mange Ram Yadav. Structural Investigations of Acridine Derivatives by CoMFA and CoMSIA Reveal Novel Insight into Their Structures toward DNA G-Quadruplex Mediated Telomerase Inhibition and Offer a Highly Predictive 3D-Model for Substituted Acridines. Journal of Chemical Information and Modeling 2009, 49 (5) , 1298-1311. https://doi.org/10.1021/ci900036w
63. Kah Wai Lim, Samir Amrane, Serge Bouaziz, Weixin Xu, Yuguang Mu, Dinshaw J. Patel, Kim Ngoc Luu and Anh Tuân Phan. Structure of the Human Telomere in K+ Solution: A Stable Basket-Type G-Quadruplex with Only Two G-Tetrad Layers. Journal of the American Chemical Society 2009, 131 (12) , 4301-4309. https://doi.org/10.1021/ja807503g
64. Herry Martadinata and Anh Tuân Phan. Structure of Propeller-Type Parallel-Stranded RNA G-Quadruplexes, Formed by Human Telomeric RNA Sequences in K+ Solution. Journal of the American Chemical Society 2009, 131 (7) , 2570-2578. https://doi.org/10.1021/ja806592z
65. Dik-Lung Ma, Chi-Ming Che and Siu-Cheong Yan. Platinum(II) Complexes with Dipyridophenazine Ligands as Human Telomerase Inhibitors and Luminescent Probes for G-Quadruplex DNA. Journal of the American Chemical Society 2009, 131 (5) , 1835-1846. https://doi.org/10.1021/ja806045x
66. William C. Drewe, Rupesh Nanjunda, Mekala Gunaratnam, Monica Beltran, Gary N. Parkinson, Anthony P. Reszka, W. David Wilson and Stephen Neidle. Rational Design of Substituted Diarylureas: A Scaffold for Binding to G-Quadruplex Motifs. Journal of Medicinal Chemistry 2008, 51 (24) , 7751-7767. https://doi.org/10.1021/jm801245v
67. Raphaël Rodriguez, Sebastian Müller, Justin A. Yeoman, Chantal Trentesaux, Jean-François Riou and Shankar Balasubramanian. A Novel Small Molecule That Alters Shelterin Integrity and Triggers a DNA-Damage Response at Telomeres. Journal of the American Chemical Society 2008, 130 (47) , 15758-15759. https://doi.org/10.1021/ja805615w
68. Giuseppe Zagotto, Claudia Sissi, Lorena Lucatello, Claudia Pivetta, Sergio A. Cadamuro, Keith R. Fox, Stephen Neidle and Manlio Palumbo . Aminoacyl−Anthraquinone Conjugates as Telomerase Inhibitors: Synthesis, Biophysical and Biological Evaluation. Journal of Medicinal Chemistry 2008, 51 (18) , 5566-5574. https://doi.org/10.1021/jm800160v
69. Amit Arora and Souvik Maiti. Effect of Loop Orientation on Quadruplex−TMPyP4 Interaction. The Journal of Physical Chemistry B 2008, 112 (27) , 8151-8159. https://doi.org/10.1021/jp711608y
70. Saurabh Agrawal, Rajendra Prasad Ojha and Souvik Maiti . Energetics of the Human Tel-22 Quadruplex−Telomestatin Interaction: A Molecular Dynamics Study. The Journal of Physical Chemistry B 2008, 112 (22) , 6828-6836. https://doi.org/10.1021/jp7102676
71. Nancy H. Campbell, Gary N. Parkinson, Anthony P. Reszka and Stephen Neidle. Structural Basis of DNA Quadruplex Recognition by an Acridine Drug. Journal of the American Chemical Society 2008, 130 (21) , 6722-6724. https://doi.org/10.1021/ja8016973
72. Ana G. Petrovic and, Prasad L. Polavarapu. The Quadruplex−Duplex Structural Transition of Polyriboguanylic Acid. The Journal of Physical Chemistry B 2008, 112 (7) , 2245-2254. https://doi.org/10.1021/jp0758723
73. W. David Wilson and Hiroshi Sugiyama . First International Meeting on Quadruplex DNA. ACS Chemical Biology 2007, 2 (9) , 589-594. https://doi.org/10.1021/cb7001686
74. Yong Xue,, Zhong-yuan Kan,, Quan Wang,, Yuan Yao,, Jiang Liu,, Yu-hua Hao, and, Zheng Tan. Human Telomeric DNA Forms Parallel-Stranded Intramolecular G-Quadruplex in K+ Solution under Molecular Crowding Condition. Journal of the American Chemical Society 2007, 129 (36) , 11185-11191. https://doi.org/10.1021/ja0730462
75. Dah-Yen Yang, Ta-Chau Chang, and, Sheh-Yi Sheu. Interaction between Human Telomere and a Carbazole Derivative:  A Molecular Dynamics Simulation of a Quadruplex Stabilizer and Telomerase Inhibitor. The Journal of Physical Chemistry A 2007, 111 (38) , 9224-9232. https://doi.org/10.1021/jp071963o
76. Primož Šket and, Janez Plavec. Not All G-Quadruplexes Exhibit Ion-Channel-like Properties:  NMR Study of Ammonium Ion (Non)movement within the d(G3T4G4)2 Quadruplex. Journal of the American Chemical Society 2007, 129 (28) , 8794-8800. https://doi.org/10.1021/ja0710003
77. Jianying Qi and, Richard H. Shafer. Human Telomere Quadruplex:  Refolding and Selection of Individual Conformers via RNA/DNA Chimeric Editing. Biochemistry 2007, 46 (25) , 7599-7606. https://doi.org/10.1021/bi602392u
78. Hai-Qing Yu,, Daisuke Miyoshi, and, Naoki Sugimoto. Characterization of Structure and Stability of Long Telomeric DNA G-Quadruplexes. Journal of the American Chemical Society 2006, 128 (48) , 15461-15468. https://doi.org/10.1021/ja064536h
79. Adam D. Moorhouse,, Ana Mafalda Santos,, Mekala Gunaratnam,, Michael Moore,, Stephen Neidle, and, John E. Moses. Stabilization of G-Quadruplex DNA by Highly Selective Ligands via Click Chemistry. Journal of the American Chemical Society 2006, 128 (50) , 15972-15973. https://doi.org/10.1021/ja0661919
80. Joan Casals,, Laurent Debéthune,, Karine Alvarez,, Antonina Risitano,, Keith R. Fox,, Anna Grandas, and, Enrique Pedroso. Directing Quadruplex-Stabilizing Drugs to the Telomere:  Synthesis and Properties of Acridine−Oligonucleotide Conjugates. Bioconjugate Chemistry 2006, 17 (5) , 1351-1359. https://doi.org/10.1021/bc060194t
81. Julie E. Reed,, Anna Arola Arnal,, Stephen Neidle, and, Ramón Vilar. Stabilization of G-Quadruplex DNA and Inhibition of Telomerase Activity by Square-Planar Nickel(II) Complexes. Journal of the American Chemical Society 2006, 128 (18) , 5992-5993. https://doi.org/10.1021/ja058509n
82. Erin Shammel Baker,, Jeong Tae Lee,, Jonathan L. Sessler, and, Michael T. Bowers. Cyclo[n]pyrroles:  Size and Site-Specific Binding to G-Quadruplexes. Journal of the American Chemical Society 2006, 128 (8) , 2641-2648. https://doi.org/10.1021/ja0564968
83. Evonne M. Rezler,, Jeyaprakashnarayanan Seenisamy,, Sridevi Bashyam,, Mu-Yong Kim,, Elizabeth White,, W. David Wilson, and, Laurence H. Hurley. Telomestatin and Diseleno Sapphyrin Bind Selectively to Two Different Forms of the Human Telomeric G-Quadruplex Structure. Journal of the American Chemical Society 2005, 127 (26) , 9439-9447. https://doi.org/10.1021/ja0505088
84. Samy Al-Rawi,, Carolin Ahlborn, and, Clemens Richert. 3‘-Immobilized Probes with 2‘-Caps:  Synthesis of Oligonucleotides with 2‘-N-Methyl-2‘-(anthraquinone carboxamido)uridine Residues. Organic Letters 2005, 7 (8) , 1569-1572. https://doi.org/10.1021/ol0502432
85. Jeyaprakashnarayanan Seenisamy,, Sridevi Bashyam,, Vijay Gokhale,, Hariprasad Vankayalapati,, Daekyu Sun,, Adam Siddiqui-Jain,, Nicole Streiner,, Kazuo Shin-ya,, Elizabeth White,, W. David Wilson, and, Laurence H. Hurley. Design and Synthesis of an Expanded Porphyrin That Has Selectivity for the c-MYC G-Quadruplex Structure. Journal of the American Chemical Society 2005, 127 (9) , 2944-2959. https://doi.org/10.1021/ja0444482
86. Bhaskar Datta,, Mark E. Bier,, Subhadeep Roy, and, Bruce A. Armitage. Quadruplex Formation by a Guanine-Rich PNA Oligomer. Journal of the American Chemical Society 2005, 127 (12) , 4199-4207. https://doi.org/10.1021/ja0446202
87. Loryn R. Keating and, Veronika A. Szalai. Parallel-Stranded Guanine Quadruplex Interactions with a Copper Cationic Porphyrin. Biochemistry 2004, 43 (50) , 15891-15900. https://doi.org/10.1021/bi0483209
88. Sachin D. Patel,, Mark Isalan,, Gérald Gavory,, Sylvain Ladame,, Yen Choo, and, Shankar Balasubramanian. Inhibition of Human Telomerase Activity by an Engineered Zinc Finger Protein that Binds G-Quadruplexes. Biochemistry 2004, 43 (42) , 13452-13458. https://doi.org/10.1021/bi048892t
89. Anil K. Mehta,, Yuda Shayo,, Hariprasad Vankayalapati,, Laurence H. Hurley, and, Jacob Schaefer. Structure of a Quinobenzoxazine−G-Quadruplex Complex by REDOR NMR. Biochemistry 2004, 43 (38) , 11953-11958. https://doi.org/10.1021/bi049697h
90. Wei Li,, Daisuke Miyoshi,, Shu-ichi Nakano, and, Naoki Sugimoto. Structural Competition Involving G-Quadruplex DNA and Its Complement. Biochemistry 2003, 42 (40) , 11736-11744. https://doi.org/10.1021/bi034168j
91. R. John Harrison,, Javier Cuesta,, Gianni Chessari,, Martin A. Read,, Sanji K. Basra,, Anthony P. Reszka,, James Morrell,, Sharon M. Gowan,, Christopher M. Incles,, Farial A. Tanious,, W. David Wilson,, Lloyd R. Kelland, and, Stephen Neidle. Trisubstituted Acridine Derivatives as Potent and Selective Telomerase Inhibitors. Journal of Medicinal Chemistry 2003, 46 (21) , 4463-4476. https://doi.org/10.1021/jm0308693
92. Frederic Rosu,, Edwin De Pauw,, Lionel Guittat,, Patrizia Alberti,, Laurent Lacroix,, Patrick Mailliet,, Jean-François Riou, and, Jean-Louis Mergny. Selective Interaction of Ethidium Derivatives with Quadruplexes:  An Equilibrium Dialysis and Electrospray Ionization Mass Spectrometry Analysis. Biochemistry 2003, 42 (35) , 10361-10371. https://doi.org/10.1021/bi034531m
93. Hsu-Shan Huang,, Jeng-Fong Chiou,, Yaou Fong,, Ching-Cheng Hou,, Yu-Cheng Lu,, Jen-Yi Wang,, Jing-Wen Shih,, Yen-Ru Pan, and, Jing-Jer Lin. Activation of Human Telomerase Reverse Transcriptase Expression by Some New Symmetrical Bis-Substituted Derivatives of the Anthraquinone. Journal of Medicinal Chemistry 2003, 46 (15) , 3300-3307. https://doi.org/10.1021/jm020492l
94. James A. Schouten,, Sylvain Ladame,, Stephen J. Mason,, Matthew A. Cooper, and, Shankar Balasubramanian. G-Quadruplex-Specific Peptide−Hemicyanine Ligands by Partial Combinatorial Selection. Journal of the American Chemical Society 2003, 125 (19) , 5594-5595. https://doi.org/10.1021/ja029356w
95. Marie-Paule Teulade-Fichou,, Carolina Carrasco,, Lionel Guittat,, Christian Bailly,, Patrizia Alberti,, Jean-Louis Mergny,, Arnaud David,, Jean-Marie Lehn, and, W. David Wilson. Selective Recognition of G-Quadruplex Telomeric DNA by a Bis(quinacridine) Macrocycle. Journal of the American Chemical Society 2003, 125 (16) , 4732-4740. https://doi.org/10.1021/ja021299j
96. George R. Clark,, Patrycja D. Pytel,, Christopher J. Squire, and, Stephen Neidle. Structure of the First Parallel DNA Quadruplex-Drug Complex. Journal of the American Chemical Society 2003, 125 (14) , 4066-4067. https://doi.org/10.1021/ja0297988
97. Mu-Yong Kim,, Wenhu Duan,, Mary Gleason-Guzman, and, Laurence H. Hurley. Design, Synthesis, and Biological Evaluation of a Series of Fluoroquinoanthroxazines with Contrasting Dual Mechanisms of Action against Topoisomerase II and G-Quadruplexes. Journal of Medicinal Chemistry 2003, 46 (4) , 571-583. https://doi.org/10.1021/jm0203377
98. Mitsu S. Reddy and, Susan H. Hardin. Features in Short Guanine-Rich Sequences That Stimulate DNA Polymerization in Vitro. Biochemistry 2003, 42 (2) , 350-362. https://doi.org/10.1021/bi020380w
99. Zhi Chen,, Brett P. Monia, and, David R. Corey. Telomerase Inhibition, Telomere Shortening, and Decreased Cell Proliferation by Cell Permeable 2‘-O-Methoxyethyl Oligonucleotides. Journal of Medicinal Chemistry 2002, 45 (25) , 5423-5425. https://doi.org/10.1021/jm025563v
100. Tadayuki Uno,, Katsumasa Aoki,, Tomoko Shikimi,, Yumi Hiranuma,, Yoshikazu Tomisugi, and, Yoshinobu Ishikawa. Copper Insertion Facilitates Water-Soluble Porphyrin Binding to rA·rU and rA·dT Base Pairs in Duplex RNA and RNA·DNA Hybrids. Biochemistry 2002, 41 (43) , 13059-13066. https://doi.org/10.1021/bi026139z