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Keyong Ho Lee, Hee Sun Hong, Chi Ho Lee, Chang Han Kim, Induction of Apoptosis in Human Leukaemic Cell Lines K562, HL60 and U937 by Diethylhexylphthalate Isolated from Aloe vera Linne, Journal of Pharmacy and Pharmacology, Volume 52, Issue 8, August 2000, Pages 1037–1041, https://doi.org/10.1211/0022357001774778
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Abstract
We investigated the effect of diethylhexylphthalate (DEHP) from Aloe vera Linne on the apoptosis of human leukaemic cell lines K562, HL60 and U937 to examine its pharmacological activity.
At a level of 10 μ mL−1 DEHP a significant anti-leukaemic effect was observed for all three cell lines, as measured by clonogenic assay. After treatment with 10 μg mL−1 DEHP for 4 h, agarose gel electrophoresis and flow cytometric analysis confirmed the occurrence of apoptosis.
These results indicate that DEHP isolated from Aloe vera Linne has a potent anti-leukaemic effect, and thus represents a new type of pharmacological activity with respect to human leukaemic cells.
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2000 Royal Pharmaceutical Society of Great Britain
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