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Review

Contribution of Non-Coding RNAs to Anticancer Effects of Dietary Polyphenols: Chlorogenic Acid, Curcumin, Epigallocatechin-3-Gallate, Genistein, Quercetin and Resveratrol

by
Sumio Hayakawa
1,*,
Tomokazu Ohishi
2,3,
Yumiko Oishi
1,
Mamoru Isemura
4 and
Noriyuki Miyoshi
5,*
1
Department of Biochemistry and Molecular Biology, Graduate School of Medicine, Nippon Medical School, Bunkyo-ku, Tokyo 113-8602, Japan
2
Institute of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Research Foundation, Shizuoka 410-0301, Japan
3
Institute of Microbial Chemistry (BIKAKEN), Laboratory of Oncology, Microbial Chemistry Research Foundation, Shinagawa-ku, Tokyo 141-0021, Japan
4
Tea Science Center, University of Shizuoka, Shizuoka 422-8526, Japan
5
Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka 422-8526, Japan
*
Authors to whom correspondence should be addressed.
Antioxidants 2022, 11(12), 2352; https://doi.org/10.3390/antiox11122352
Submission received: 1 November 2022 / Revised: 18 November 2022 / Accepted: 24 November 2022 / Published: 28 November 2022
(This article belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)
Browse Figure
Review Reports Versions Notes

Abstract

:
Growing evidence has been accumulated to show the anticancer effects of daily consumption of polyphenols. These dietary polyphenols include chlorogenic acid, curcumin, epigallocatechin-3-O-gallate, genistein, quercetin, and resveratrol. These polyphenols have similar chemical and biological properties in that they can act as antioxidants and exert the anticancer effects via cell signaling pathways involving their reactive oxygen species (ROS)-scavenging activity. These polyphenols may also act as pro-oxidants under certain conditions, especially at high concentrations. Epigenetic modifications, including dysregulation of noncoding RNAs (ncRNAs) such as microRNAs, long noncoding RNAs, and circular RNAs are now known to be involved in the anticancer effects of polyphenols. These polyphenols can modulate the expression/activity of the component molecules in ROS-scavenger-triggered anticancer pathways (RSTAPs) by increasing the expression of tumor-suppressive ncRNAs and decreasing the expression of oncogenic ncRNAs in general. Multiple ncRNAs are similarly modulated by multiple polyphenols. Many of the targets of ncRNAs affected by these polyphenols are components of RSTAPs. Therefore, ncRNA modulation may enhance the anticancer effects of polyphenols via RSTAPs in an additive or synergistic manner, although other mechanisms may be operating as well.

1. Introduction

A number of epidemiological studies have provided evidence for the anticancer effects of daily polyphenol intake [1,2,3,4,5,6]. These dietary polyphenols include chlorogenic acid (CGA), curcumin (CUR), epigallocatechin-3-O-gallate (EGCG), genistein (GEN), quercetin (QUE) and resveratrol (RES), which are six major polyphenols in our dietary life and are found in vegetables, fruits, and beverages. Preclinical and cell-based studies have supported their anticancer effects and provided a mechanism of action for these polyphenols [1,2,3,5]. Recent studies have shown involvement of epigenetic modifications including dysregulation of noncoding RNAs (ncRNAs) such as micro RNAs (miRs), long noncoding RNAs (lncRs), and circular RNAs (circRs).
We have provided updated information from human studies supporting the anticancer effects of consumption of green tea, coffee, red wine, soybeans, and curry and discussed the involvement of miRs in polyphenol action mechanisms (Table 1 and Table 2). Previous data have shown that the six major dietary polyphenols, CGA, CUR, EGCG, GEN, QUE, and RES, have similar properties since they can act as antioxidants and exert the anticancer effects via reactive oxygen species (ROS)-scavenger-triggered anticancer pathways (RSTAPs) (Figure 1) [7,8]. These dietary polyphenols are also known to act as pro-oxidants and ROS generated can activate AMP-activated protein kinase (AMPK) which will result in polyphenols’ anticancer effects (Figure 1). Moreover, data indicated that at least three of the six polyphenols can commonly modulate several miRs associated with RSTAPs [7,8].
In this review, we further discuss the miR-modulating effects of polyphenols, which have been reported in studies using one or two of the six dietary polyphenols (Table 3 and Table 4). Furthermore, based on recent evidence on involvement of lncRs and circRs in anticancer mechanisms of these polyphenols, we summarize the modulatory effects of six dietary polyphenols on lncRs and circRs in relation to their anticancer effects.

2. Involvements of miRs in Polyphenol-Mediated Anticancer Mechanisms

miRs are defined as small single-stranded molecules (approximately 20 to 25 nucleotides) and can regulate gene expression at the transcriptional and post-transcriptional levels, leading to modulation of beneficial health effects exerted by these polyphenols in diseases including cancer [7,8].
Table 1 and Table 2 summarize miRs modulated by at least three of six dietary polyphenols. Four of six dietary polyphenols upregulate miR-16, 34a and 141, and downregulate miR-20a and 221; five of six dietary polyphenols upregulate miR-145 and downregulate miR-21 and 155. Table 1 and Table 2 also list the molecular targets of miRs that are modulated by these polyphenols; targets associated with RSTAPs (Figure 1) are also shown in these tables. Thus, it appears that six dietary polyphenols can exert their anticancer effects not only by directly involving RSTAPs, but also by miR-mediated regulation of the molecular targets associated with RSTAPs.
One or two of the miRs up- and down-regulated by six polyphenols for which studies have been reported are listed in Table 3 and Table 4, respectively, together with determined or proposed targets of these miRs. Many miRs can target components of RSTAPs, but some contribute to other mechanisms that are not depicted in these pathways (Figure 1). Based on previous findings on positive crosstalk between NF-κB and Wnt/β-catenin signaling [144,145], the Wnt/β-catenin signaling is connected in Figure 1. Furthermore, previous findings are incorporated to show that TNF-α activates Wnt/β-catenin pathway, leading to increases in cancer stemness and epithelial-to-mesenchymal transition (EMT) which are involved in cancer cell renewals and tumorigenesis [146,147,148].

3. Involvements of lncRs in RSTAPs

LncRs are more than 200 bases long and are species/tissue specific. LncRs can interact with DNA, RNA, and proteins to regulate a wide range of biological processes [149,150]. Recent microarray analyses and next-generation sequencing assays have found that lncRs can modulate gene expression at multiple levels, including regulation at the epigenetic, transcriptional, and post-transcriptional levels. In addition, lncRs can act as sponges or molecular decoys for miRs, and reduce a population of valid specific miR, and thus, influence miR activity.
There are two major categories of lncRs, which are defined as oncogenic lncRs such as MALAT1, HOTAIR, SOX2-OT and H19, and tumor suppressing lncRs such as MEG3, PANDAR, GAS5, and TUG1 according to their pathological features [151]. Evidence is accumulating that dietary polyphenols including six polyphenols can modulate lncRs. Table 4 shows the modulations of lncRs by six polyphenols. The possible contribution of these lncRs to RSTAPs is shown in Figure 1.

3.1. lncR Modulations by CGA

GAS5
For reasons unknown, information on CGA’s actions on lncRs is quite limited. In a study on CGA’s preventive effects on Salmonella typhimurium-induced intestinal diseases, Tan et al. [152] found that CGA prevented pathological damages and upregulated intestinal lncR GAS5. Cellular experiments showed that GAS5 competitively bound oncogenic miR-23a to reduce the population of miR-23a as a molecular sponge, resulting in upregulation of phosphatase and PTEN. Since the increased expression of PTEN is implicated in RSTAPs (Figure 1), this finding could be applied to explain the anticancer activity of CGA, although this needs to be validated using cancer cells.
TUG1
In a study on a role of CGA in protection against oxidative stress injury in glaucoma, Gong et al. [153] found that CGA promoted Nrf2 expression via upregulation of lncR TUG1 in retinal ganglion RGC-5 cells and decreased cell apoptosis. Based on this finding one may expect that CGA exerts anticancer effects via its upregulation of TUG1, since antioxidative natural phytochemicals have been reported to prevent carcinogenesis by upregulation of Nrf2 [154,155].

3.2. lncR Modulations by CUR

AK294004
In nasopharyngeal carcinoma (NPC) cell lines (CNE-2), a microarray analysis showed that expression of a number of lncRs was changed by X-ray irradiation and that the expression of 116 ncRNAs was restored by CUR [156]. The results of qRT-PCR confirmed these changes in six lncRs (AF086415, AK095147, RP1-179N16.3, MUDENG, AK056098 and AK294004). Functional studies suggested that cyclin D1 is a direct target of AK294004. Radiotherapy is one of the most effective treatment modalities for NPC patients, and radioresistance is the main risk factor contributing to poor prognosis. This resistance occurs with the first X-ray treatment and the survived cells become more resistant to the second X-ray treatment, leading to invalidation of the treatment. Thus, CUR can be expected to improve radiosensitivity by altering expression of these lncRs.
GAS5
Dendrosomal CUR treatment of MCF7, MDA-MB231 and SKBR3 cells increased the expression of Tusc7 and GAS5 [157]. GAS5 downregulation suppressed many anticancer effects of dendrosomal CUR in breast cancer (BCa) cells. Because an amplified level of GAG5 has been reported to reduce chemotherapy resistance [158], Co-treatment of dendrosomal CUR with GAS5 overexpression could be a clinically useful tool against drug-resistant BCa cells.
H19
Kujundzić et al. [159] found that CUR inhibited cell proliferation and suppressed expression of lncR H19 in several human cancer cell lines such as HCT 116, SW 620, and HeLa. CUR’s downregulation of H19 expression was not found in primary normal thyroid cells [159]. Similarly, Liu et al. [160] found that CUR inhibited the proliferation of gastric cancer (GCa) SGC-7901 cells, suppressed H19 expression, and increased p53 expression. Ectopic expression of H19 attenuated CUR-induced apoptosis and downregulated p53 expression. CUR downregulated the expression of c-Myc oncogene and addition of c-Myc protein in the cell culture medium attenuated the CUR-induced downregulation of H19 expression, which may explain part of the anticancer mechanism of CUR.
In tamoxifen-resistant MCF-7 BCa cells, CUR decreased the expression levels of the epithelial marker E-cadherin, increased the expression levels of mesenchymal marker N-cadherin, and decreased H19 expression [161]. Overexpression of H19 induced EMT, invasion and migration by upregulating Snail, a key regulator of the EMT process. CUR attenuated H19-induced alterations in N-cadherin and E-cadherin expression levels and inhibited H19-induced invasion and migration, indicating that CUR may prevent H19-associated cancer cell metastasis.
KCNQ1OT1
The cisplatin-resistant colorectal cancer (CRC) HCT8/DDP cells exhibited higher expression levels of oncogenic KCNQ1OT1 compared to non-resistant cells. Zheng et al. [162] found that CUR promoted apoptosis in HCT8/DDP cells and silencing of KCNQ1OT1 enhanced apoptosis in the cisplatin-resistant cells. KCNQ1OT1 was found to eliminate the suppressive effect of miR-497 on expression of anti-apoptotic Bcl-2. KCNQ1OT1 overexpression counteracted the effect of CUR on these cells via miR-497/Bcl-2 axis. CUR downregulated KCNQ1OT1 expression, leading to suppression of cisplatin resistance. This may explain CUR’s reducing effect on cisplatin resistance.
LINC00691
In papillary thyroid cancer B-CPAP cells, CUR decreased cell proliferation, promoted apoptosis, and inhibited LINC00691 expression [163]. CUR administration or transfection of si-LINC00691 caused downregulation of AKT leading to apoptosis in these cells, suggesting that inhibition of LINC00691 is involved in the anticancer effect of CUR.
linc-PINT
Microarray experiments with acute lymphoblastic leukemia cells from the patients showed that 43 lncRs were aberrantly expressed as compared to healthy donor blood cells [164]. qRT-PCR found that 15 out of the 16 tested lncRs examined had the same expression pattern in the expression array including downregulation of linc-PINT. Overexpression of this lncR in Molt-4 cells induced the transcription of HMOX1, which reduced cell viability. CUR was found to upregulate the expression of linc-PINT and HMOX1 in Molt-4 cells, suggesting that upregulation of linc-PINT may be one of the CUR’s anticancer mechanisms.
MEG3
Alghanimi and Ghasemian [165] showed that dendrosomal CUR promoted cell death in BCa MCF-7 cells, increased gene expression of lncR MEG3, and decreased expression of FOXCUT gene. Since previous studies have shown that overexpression of MEG3 is associated with inhibition of cancer cell growth [166], CUR’s upregulation of this lncR may contribute to its anticancer effects. CUR induced apoptosis of gemcitabine-resistant non-small cell lung cancer (NSCLC) cell lines A549/GR and H520/GR and upregulated the expression of MEG3 and PTEN [167]. MEG3 overexpression increased PTEN expression and knockdown of MEG3 decreased its expression. MEG3 knockdown or PTEN knockdown mitigated CUR’s effects on these cells.
NRB2
Yu et al. [168] found that CUR upregulated lncR NBR2 in CRC cell lines including HCT116, HCT8, SW620, and SW480, and inhibited CRC cell proliferation by activating the AMPK pathway and inactivating mTOR. These effects of CUR were cancelled by knockdown of NBR2, indicating that modulation of the NBR2/AMPK/mTOR pathway may be involved in the anticancer effects of CUR.
PANDAR
CUR increased PANDAR expression in CRC DLD-1 cells and silencing of PANDAR increased apoptosis and attenuated cell senescence by stimulating expression of PUMA [169]. Knockdown of PANDAR switched CUR-induced senescence to apoptosis, suggesting the usefulness of CUR in CRC therapy. Since PUMA has been reported to initiate apoptosis by dissociating Bax and Bcl-X(L), leading to activation of proapoptotic function of Bax [170], it may be speculated that CUR-mediated upregulation of PANDAR may involve in the anticancer effect of CUR via Bax activation.
PVT1
The EZH2, a subunit of polycomb repressive complex 2 (PRC2), is known to have an important role in drug resistance. EZH2 interacts with several lncRs including PVT1 to modulate EMT and cancer stemness related to drug resistance. Yoshida et al. [171] found that CUR sensitized chemoresistant cancer cells by inhibiting the expression of EZH2 and PVT1 using gemcitabine-resistant pancreatic ductal adenocarcinoma cells, suggesting that CUR can overcome chemoresistance in pancreatic ductal adenocarcinoma patients via inhibition of the PRC2-PVT1-c-Myc axis.
ROR
Shao et al. [172] demonstrated that CUR inhibited the cell growth of human hepatoma SMMC7721 and Huh-7 cells through inducing cell cycle arrest and apoptosis and downregulated ROR expression. Overexpression of ROR restored CUR-induced growth inhibition and inactivated Wnt/β-catenin signaling, suggesting that downregulation of ROR is involved in the anticancer effects of CUR.
In CD44+/CD133+ human prostate cancer (PCa) stem cells derived from the PCa cell lines Du145 and 22RV1, CUR treatment resulted in the inhibition of cell growth and invasion, and cell cycle arrest along with decreased expression of stem cell marker proteins such as Oct4 [37]. In addition, high miR-145 expression and suppression of ROR expression were observed in the CUR-treated cells. Bioinformatic analysis and luciferase activity assays showed that Oct4 and ROR directly compete for miR-145 binding. Thus, CUR’s anticancer activity involves its downregulation of ROR which functions as miR sponge to competitively bind tumor suppressing miR-145, contributing to an increase in the population of miR-145, resulting in downregulation of Oct4, which plays a critical role in cancer development and progression [8,173].
UCA1
In A549 cells, CUR inhibited cell proliferation and cyclin D1 expression, and enhanced cell apoptosis [174]. CUR inhibited UCA1 expression, leading to downregulation of Wnt/mTOR pathway. Overexpression of UCA1 attenuated the effect of CUR on apoptosis. Based on previous findings that knockdown of UCA1 reduces c-Myc expression [175], CUR’s anticancer effect may be associated with downregulation of c-Myc via downregulation of UCA1.
XIST
Sun et al. [176] found that XIST was downregulated in renal cell carcinoma (RCC) tissues and cells such as ACHN, Caki-1, Caki-2, and 786-O. Overexpression of XIST suppressed cell proliferation, induced cell cycle arrest at G0/G1 in cultured cells, and inhibited tumor growth in a xenograft model. XIST directly interacted with miR-106b-5p and increased p21 expression. CUR regulated XIST/miR-106b-5p/p21 axis in RCC cells, indicating a role of XIST in RCC.

3.3. lncR Modulations by EGCG

AF085935
Sabry et al. [177] showed that the combination of EGCG and metformin was highly effective against the proliferation of hepatoma HepG2 cells. This combination downregulated AF085935 and glypican-3 and promoted apoptosis via upregulation of caspase 3 and downregulation of survivin. However, the direct target of AF085935 has not yet been identified.
LINC00511
Zhao et al. [111] found that EGCG modulated the expression of a number of lncRs in GCa AGS and SGC7901 cells. EGCG suppressed oncogenic LINC00511 and knockdown of LINC00511 inhibited cell proliferation and promoted cell death. LINC00511 could decrease the expression of miR-29b, followed by inducing GCa development. Knockdown of miR-29b rescued the effects of LINC00511 silencing. Overexpression of KDM2A, a target of miR-29b, restored the level of LINC00511.
NEAT1
CTR1 is known to promote cisplatin internalization in tumor cells. Jiang et al. [135] found that EGCG induced CTR1 and enhanced cisplatin sensitivity in NSCLC cells. miR-98-5p suppressed CTR1 gene expression, while NEAT1 enhanced it. Bioinformatics analysis showed that miR-98-5p is a target of CTR1. NEAT1 can be a competing endogenous lncR that upregulates EGCG-induced CTR1 by sponging miR-98-5p in these cells, suggesting that EGCG is an effective chemotherapeutic agent in the lung cancer treatment. Similarly, Chen et al. [178] found that EGCG increased ROS levels, expression of CTR1 and NEAT1 in tumor tissue, and suppressed ERK1/2 and p-ERK1/2 in a nude mouse xenografts model of lung cancer.
Cancer stem cells have been implicated as a major player in tumor metastasis, tumor recurrence, and chemotherapy resistance. CTR1 is associated with cisplatin resistance. Jiang et al. [179] found that in cancer stem cell-rich cells derived from parent lung cancer NSCLC cells, NEAT 1 was upregulated and CTR1 was downregulated. EGCG downregulated NEAT1 and suppressed the stemness triggered by overexpressing NEAT1 via inducing CTR1 expression. Wnt signaling pathway and EMT process were shown to be involved in NEAT1-induced cancer cell stemness in NSCLC.
SOX2OT variant 7
Wang et al. [180] found the synergistic effect of EGCG with an antitumor drug doxorubicin on osteosarcoma cells. EGCG targeted SOX2OT variant 7 via Notch3 signaling pathway and decreased stemness including drug resistance, tumorigenic ability, and self-renewal ability of these cells.
Other studies
The results of lncR microarray analysis revealed that EGCG treatment of lung cancer cells caused significant alterations in a total of 960 lncRs and 1434 mRNAs [181]. Among them, upregulation of five lncRs (ENSG00000272796.1, ENSG00000254054.2, ENSG00000260630.2; SNAI3-AS1, ENSG00000235142.2; LINC0532 and ENSG00000224063.1; CALCRL-AS1) and downregulation of five lncRs (ENSG00000251018.2, ENSG00000226403.1, PSMC3IP, ENSG00000230109.1 and SG00000130600.10) were confirmed by qRT-PCR. Bioinformatic analysis suggests that potential anticancer mechanisms by which EGCG regulates lncRs are associated with RSTAP members such as AKT1, caspase 3, and p53 and others, but the individual targets of these lncRs remain to be determined.

3.4. lncR Modulations by GEN

HOTAIR
In PCa cells, PC3 and DU145, GEN downregulated oncogenic HOTAIR and upregulated miR-34a [29]. Luciferase reporter assays showed that miR-34a bound to HOTAIR, leading to downregulation of HOTAIR. Knockdown of HOTAIR by siRNA caused inhibition of PCa cell growth, migration and invasion and induced apoptosis, indicating that GEN exerts its anticancer effects via downregulation of HOTAIR, which is also targeted by miR-34a. Similarly, Chiyomaru et al. [35] reported that GEN downregulated HOTAIR and upregulated miR-141 which bound to HOTAIR, leading to suppression of HOTAIR in RCC 786-O and ACHN cells. GEN inhibited proliferation and induced apoptosis in BCa MCF-7 cells. GEN decreased AKT phosphorylation and the expression of its downstream target, HOTAIR [182].
Imai-Sumida et al. [183] showed that GEN inhibited the interaction between HOTAIR and PRC2 in RCC 786-O and ACHN cells, leading to tumor suppression. GEN upregulated the tight junction protein ZO-1 by reducing the recruitment of PRC2 to the ZO-1 promoter. GEN also inhibited interaction between HOTAIR and SMARCB1, one of subunits of the human chromatin remodeling complex. These findings suggest that suppression of HOTAIR/chromatin remodeling pathways is involved in GEN’s anticancer effects against these cancer cells. Other studies have demonstrated that HOTAIR promotes cancer cell proliferation by activating the PI3K/AKT/mTOR signaling pathway [184,185], suggesting that GEN exerts its anticancer effects by downregulating HOTAIR through inhibition of this signaling pathway.
TTTY18
GEN suppressed CRC cell growth and migration and promoted apoptosis [186]. GEN downregulated TTTY18 expression and phosphorylation of AKT and p38 MAPK, suggesting that inhibition of TTTY18/AKT pathway is involved in GEN’s anticancer activity.

3.5. lncR Modulations by QUE

MALAT1
By data mining including computational analysis, Li et al. [187] identified QUE’s therapeutic candidate genes in cervical cancer HeLa cells. Among them, EGFR, JUN, AR, CD44, and MUC1 were selected, and MALAT1, 10 miRs, and 71 circRs upstream of these genes were determined. These findings lead to the construction of a regulatory network of lncR/circR-miR-mRNA pathway and provided a theoretical basis for targeted therapy of cervical cancer. In PCa PC-3 cells, QUE downregulated the expression of oncogenic MALAT1 and inhibited the growth of these cells and their xenograft tumors [188]. QUE suppressed the EMT process, promoted apoptosis, and downregulated PI3K/AKT signaling pathway. Overexpression of MALAT1 attenuated the QUE’s effects.
QUE treatment decreased the cell viability of HUVEC cells and downregulated the expression of MALAT1 and MIAT [189]. Since MALAT1 is related to endothelial cell growth, metastasis, and angiogenesis and since MIAT regulates angiogenesis through interaction with miR-150-5p, which can target VEGF, QUE may exert its anticancer effects through downregulation of these lncRs.
NEAT1
Sheng et al. [190] found that in a mouse model of acute pancreatitis, QUE downregulated TNF-α, IL-6, and IL-10, while upregulating miR-216b expression, leading to suppression of p38 MAPK signaling pathway. QUE downregulated NEAT1 which is a direct target of miR-216b. NEAT1 was shown to be a direct target of miR-216b and the triad of NEAT1, miR-216b, and MAP2K6 formed a competitive endogenous RNA network. These findings may partially explain QUE’s anticancer effects.
SNHG7
Chai et al. [119] found NSCLC cells had the elevated expression of oncogenic SNHG7 and the decreased expression of miR-34a-5p compared to those in normal cells. QUE downregulated SNHG7 and increased miR-34a-5p levels in these cells. Overexpression of SNHG7 or downregulation of miR-34a-5p promoted NSCLC cell growth and metastasis. The anticancer effects of QUE were counteracted by co-transfection of SNHG7 mimic or miR-34a-5p inhibitor. These results indicate that QUE may exert its anticancer effects by mediating signaling via the SNHG7/miR-34a-5p axis. Based on the previous findings that SNHG7 upregulates AKT/mTOR pathway in NSCLC cells [191], it is plausible that QUE’s downregulation of SNHG7 is related to downregulation of this pathway.
UCA1
In BCa MCF-7 cells, QUE inhibited cell proliferation and induced cell cycle arrest at G2 phase [192]. INXS is a lncRNA that is able to shift the Bcl-X alternative splicing from the anti-apoptotic Bcl-XL to the pro-apoptotic Bcl-XS, and QUE can cause INXS upregulation and UCA1 downregulation in BCa cells, suggesting QUE exerts its anticancer effects through modulation of these lncRs.

3.6. lncR Modulations by RES

AK001796
Yang et al. [193] found that AK001796 was overexpressed in lung cancer tissues and cells (A549 and H446) and its expression was downregulated in RES-treated lung cancer cells. Knockdown of AK001796 reduced cell viability and caused a cell cycle arrest at G0/G1.
DLEU2
Kay et al. [194] demonstrated that RES upregulated the tumor suppressor gene DLEU2 in 11 alternative splicing transcripts. Since DLEU2 was shown to negatively regulate cyclins E1 and D1 through upregulation of miR-15a/miR-16-1 and since overexpression of DLEU2 recovered cellular proliferation and inhibition of the colony-forming ability of tumor cells in a miR-15a/miR-16-1-dependent manner [195], RES’s upregulation of DLEU2 may contribute to its anticancer effects.
H19
In GCa SGC7901 cells, 200 µM RES was shown to increase expression of MEG3, PTTG3P and BISPR and decreased expression of GAS5 and H19 [196]. RES at 50 µM upregulated H19 and MALAT1, and knockdown of H19 in RES-treated cells increased the effect of RES on apoptosis, endoplasmic reticulum stress, and cell cycle S-phase arrest in these cells, suggesting that RES increases chemotherapy sensitivity.
MALAT1
RES inhibited invasion and metastasis of CRC LoVo cells and downregulated MALAT1 [197]. RES’s suppressive effects on tumor cell migration and invasion and protein expression of β-catenin, c-Myc, and MMP-7 were attenuated by overexpression of MALAT1. The finding suggests that suppression of Wnt/β-catenin signaling by downregulation of MALAT1 contributes to RES’s anticancer effects.
NEAT1
Geng et al. [198] found higher expression of NEAT1 in multiple myeloma U266 and LP-1 cells compared to normal bone marrow plasmocytes. RES downregulated NEAT1 and counteracted enhanced cell proliferation, migration, and invasion induced by NEAT1 overexpression. NEAT1 overexpression upregulated the expression of nuclear β-catenin, c-Myc, MMP-7 and survivin, leading to activation of the Wnt/β-catenin signaling pathway.
PCAT29
RES upregulated PCAT29 expression and attenuated its downregulation induced by IL-6 [199]. Knockdown of PCAT29 expression increased cell viability, while RES-induced upregulation of PCAT29 resulted in decreased cell viability. Since RES can downregulate IL-6 (Figure 1), RES may exert its anticancer effect by upregulating PCAT29 expression. Since PCAT29 has been reported to upregulate PTEN by downregulation of miR-494 in NSCLC [200], upregulation of PCAT29 can be reasonably related to anticancer activity of RES.
Other studies
In glioma U87 and U251 cells, RES upregulated NEAT1, MIR155HG, MEG3, and ST7OT1 during induction of apoptosis [201]. Since NEAT1 and MIR155HG are oncogenic [202,203,204] and MEG3 is tumor-suppressing [166], the effect of RES on MEG3 may be a predominant contributor to apoptosis of these cells. NEAT1 was demonstrated to activate ERK, which is a component molecule in RSTAPs (Figure 1) [202].
In colon adenocarcinoma HT-29 cells, the results of qRT-PCR indicated that RES decreased the expression of CCAT1, CRNDE, H19, HOTAIR, PCAT1, PVT1, and SNHG16, and upregulated CCAT2, MALAT1, and TUSC7 [205]. Although individual roles of these lncRs in RES’s anticancer effects are not clear, for example, downregulation of HOTAIR may be related to anticancer effects, since better disease-free survival rate was observed in colon adenocarcinoma patients with low HOTAIR expression. It may be considered that RES’s downregulation of CCAT1 contributes to the anticancer effect, because CCAT1 promotes tumor progression by stabilizing PI3K/AKT/mTOR signalling in lung adenocarcinoma [206].

3.7. Comparison of the Modulation of lncRs by Six Polyphenols

Table 5 shows comparison of the modulation of lncRs by six dietary polyphenols. Only six lncRs (GAS, H19, HOTAIR, MALAT1, NEAT1 and UCA1) have been reported to be modulated similarly by two or three dietary polyphenols (Table 5). In many cases, the modulation lncRs has been studied for one of six polyphenols, but the reason for this is unclear. One possible reason is that lncRs, which have not been studied before, are chosen as targets for study on polyphenol’s effects, because research publications are required to include novel findings. As research progresses, the number of lncRs commonly regulated by six polyphenols with similar chemical properties is likely to increase.
Table 5 also lists determined or possible targets affected by these lncRs. The above discussion and this table indicate that many targets of lncRs are related to RSTAPs, suggesting that modulation of these lncRs by six dietary polyphenols may contribute to their anticancer effects.

4. Effects of Dietary Polyphenols on CircRs

CircRs are associated with cancer development by modulating miRNAs involved in cell proliferation, migration, and carcinogenesis [207]. CircRs can reduce the population of active miRs by binding or sponging, thus affecting miR activity like lncRs aforementioned [208]. Currently, limited studies have examined the effects of polyphenols on circRs. Although microarray analysis has shown that six polyphenols affect many circRs [209,210], more research is needed on this issue.
CUR’s downregulation of circ_102115, circ_PRKCA, circ_FNDC3B, and circ_0078710
Microarray analysis of the radioresistant nasopharyngeal carcinoma cell line CNE-2 and normal cell lines identified 1042 upregulated and 1558 downregulated circRs [210]. CUR was found to confer radiosensitivity to nasopharyngeal carcinoma CNE-2 cells by regulating the circR-miR-mRNA network and inhibiting EGFR signaling, and STAT3, and GRB2. The same group also found that CUR attenuated radiation-induced upregulation of circ_102115 and miR-335-3p, and downregulation of MAPK1. These findings suggest that CUR restores the radiation sensitivity of these cancer cells [207].
Xu et al. [107] found that circ_PRKCA and integrin β1 expression were upregulated in NSCLC tissues and in H460 and A549 cells, while miR-384 was downregulated. Forced expression of integrin β1 expression attenuated the CUR’s inhibitory effect on cell viability and colony formation. CUR promoted apoptosis and reduced migration and invasion of these cells, but these effects were abolished by integrin β1 expression transfection. These results suggest that CUR inhibits cancer cell growth via downregulation of circ_PRKCA, which upregulates integrin β1 expression by adsorbing/sponging miR-384.
In RCa tissues and cells, circ_FNDC3B levels were upregulated and miR-138-5p was downregulated [211]. CUR suppressed cell proliferation and promoted apoptosis in RCa CAKI-1 and ACHN cells. CUR downregulated circ_FNDC3B and upregulated miR-138-5p. These effects were attenuated by overexpression of circ_FNDC3B or knockdown of miR-138-5p. Transfection of circ_FNDC3B attenuated CUR-induced increased apoptosis and increased expression of Bax, while the enhanced expression of cyclin D1 and bcl-2 induced by CUR were restrained. Thus, downregulation of circ_FNDC3B by CUR contributed to enhancement of apoptosis in these cells.
CUR inhibited the proliferation, migration, and invasion of hepatocellular carcinoma (HCC) cell lines HCCLM3 and Huh7 and induced apoptosis [208]. CUR downregulated the expression of circ_0078710 in these cells and siRNA knockdown of circ_0078710 enhanced CUR’s anticancer effects. CUR stimulated miR-378b expression and overexpression of miR-378b enhanced apoptosis in CUR-stimulated HCC cells. DNA primase, PRIM2 expression was reduced by silencing of circ_0078710 and increased by anti-miR378b treatment. circ_0078710 enhanced PRIM2 expression by sponging miR-378b and consequently, CUR’s downregulation of circ_0078710 increased miR378b population, resulting in downregulation of PRIM2 which is involved in cell proliferation.
GEN’s downregulation of circ_0031250
GEN inhibited cell viability and downregulated oncogenic circ_0031250 in NSCLC H292 and A549 cells [140]. Circ_0031250 knockdown using siRNA further increased the expression of Bax protein, which was upregulated by GEN. Circ_0031250 knockdown also caused enhanced apoptosis, which was mitigated by the miR-873-5p inhibitor in the presence of GEN. miR-873-5p overexpression increased Bax expression in GEN-treated cells, which was restored by FOXM1 upregulation. Thus, GEN exerts its anticancer effect on these cells by modulating circ_0031250/miR-873-5p/FOXM1 axis.
QUE’s upregulation of circ_R 8:93786223|93822563
In CRC HCT 116 cells, QUE inhibited cell proliferation and induced apoptosis. Zhang et al. [209] examined miRNA, lncR, circR, and mRNA expression profiles and found QUE-induced differential expression in 131 circRs, 240 lncRs, 83 miRs, and 1415 mRNAs in these cells. QUE upregulated the expression of miRs including miR-5096, and also circR 2:206841107|206881891 and circR 2:206866697|206881891. Furthermore, QUE decreased mRNA levels including LRG1 mRNA and lncRs including cirR 8:93786223|93822563. Binding site analysis indicated that circR 8:93786223|93822563 can interact with LRG1 mRNA through competitive binding with miR-5096. A previous report showed a strong association of LRG1 with worse overall survival in CRC. Thus, the interactive relationships of circR 8:93786223|93822563–miR-5096–LRG1 may be involved in the mechanism of action of QUE, but it appears difficult to clarify this mechanism, because QUE affects the expression of so many circRs, lncRs, miRs, and mRNAs.

5. Conclusions

Anticancer effects of dietary polyphenols, CGA, CUR, EGCG, GEN, QUE, and RES have been shown in many human, animal, and cell-based studies. These results may explain those of epidemiological studies demonstrating the reduced cancer risk of a variety of cancer types by consumption of coffee, green tea, soybeans, wine, and curry. A cohort study conducted by Wang et al. reported that the amount of total polyphenols ranged from 8.88 to 47.44 mg/day in the lowest and highest quintile, respectively, among 38,408 middle-aged and old women [212]. Several studies have shown a correlation between polyphenols-rich diets and a reduced risk of cancer [213,214]. These polyphenols have similar properties in that they can act as antioxidants to scavenge ROS, which triggers pathways leading to cell cycle arrest, apoptosis induction, anti-inflammation, and anti-angiogenesis.
These polyphenols can modulate the expression/activity of several RSTAP components by increasing the expression of tumor-suppressive ncRNAs and decreasing the expression of oncogenic ncRNAs in general. Thus, modulation of ncRNAs may additively or synergistically enhance the anticancer effects of these polyphenols via RSTAPs.
Although six dietary polyphenols have similar chemical properties, GEN and RES, and EGCG can act uniquely as phytoestrogens and a 67kDa laminin receptor, respectively, in anticancer effects [7,113,215]. These effects together with different modulation found among six dietary polyphenols on ncRNAs may explain differences in cancer-specific effects of consumption of foods containing these polyphenols observed in epidemiological studies [7,8], but more precise analysis is needed to clarify this issue.
In a recent comprehensive review, Fujimura et al. [216] have discussed that EGCG sensing by the 67kDa laminin receptor can be potentiated by a variety of biomolecules such as citrus polyphenols and sulfur-containing food factors. Therefore, it should be interesting to search cellular sensing systems for other dietary polyphenols which will lead to lower their active concentrations and examine involvements of ncRNAs in the anticancer mechanism.
Since this review is written based on the data from two databases: PubMed (https://pubmed.ncbi.nlm.nih.gov/ (accessed on 24 November 2022)) and Web of Science (http://webofknowledge.com/WOS (accessed on 24 November 2022)), there is a limitation that this review has not covered all of findings related to the present theme.

Author Contributions

S.H. Corresponding author, Literature search, Text preparation of Introduction, References, Preparation of Table 1 and Table 2; T.O. Literature search, Text preparation of Section 2 and Section 3, Table 3 and Table 4; Y.O. Project design, Outline of the whole manuscript, Literature search, Text preparation of Abstract, Conclusion; M.I. Project design, Outline of the whole manuscript, Literature search, Table 5; N.M. Corresponding author, Literature search, Preparation of Section 4, Drawing of Figure 1. All authors have read and agreed to the published version of the manuscript.

Funding

This research was funded in part by a Grant-in-Aid for Scientific Research (KAKENHI, No. JP 21H03366 to S.H.) from the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT, Tokyo) as well as the Tojuro Iijima Foundation for Food Science and Technology (S.H.) and Hoansha (S.H.).

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. Hayakawa, S.; Ohishi, T.; Miyoshi, N.; Oishi, Y.; Nakamura, Y.; Isemura, M. Anti-Cancer Effects of Green Tea Epigallocatchin-3-Gallate and Coffee Chlorogenic Acid. Molecules 2020, 25, 4553. [Google Scholar] [CrossRef] [PubMed]
  2. Fukutomi, R.; Ohishi, T.; Koyama, Y.; Pervin, M.; Nakamura, Y.; Isemura, M. Beneficial Effects of Epigallocatechin-3-O-Gallate, Chlorogenic Acid, Resveratrol, and Curcumin on Neurodegenerative Diseases. Molecules 2021, 26, 415. [Google Scholar] [CrossRef] [PubMed]
  3. Ohishi, T.; Fukutomi, R.; Shoji, Y.; Goto, S.; Isemura, M. The Beneficial Effects of Principal Polyphenols from Green Tea, Coffee, Wine, and Curry on Obesity. Molecules 2021, 26, 453. [Google Scholar] [CrossRef] [PubMed]
  4. Veeraraghavan, V.P.; Mony, U.; Renu, K.; Surapaneni, K.M.; Ammar, R.B.; AlZahrani, A.M.; Ahmed, E.A.; Rajendran, P. Effects of Polyphhenols on NcRNAs in Cancer-An Update. Clin. Exp. Pharmacol. Physiol. 2022, 49, 613–623. [Google Scholar] [CrossRef] [PubMed]
  5. Tanabe, H.; Pervin, M.; Goto, S.; Isemura, M.; Nakamura, Y. Beneficial Effects of Plant Polyphenols on Obesity Symbiosis Symbiosis Group. Obes. Control 2017, 4, 1–16. [Google Scholar] [CrossRef]
  6. Sharma, E.; Attri, D.C.; Sati, P.; Dhyani, P.; Szopa, A.; Sharifi-Rad, J.; Hano, C.; Calina, D.; Cho, W.C. Recent Updates on Anticancer Mechanisms of Polyphenols. Front. Cell Dev. Biol. 2022, 10, 1005910. [Google Scholar] [CrossRef] [PubMed]
  7. Ohishi, T.; Hayakawa, S.; Miyoshi, N. Involvement of MicroRNA Modifications in Anticancer Effects of Major Polyphenols from Green Tea, Coffee, Wine, and Curry. Crit. Rev. Food Sci. Nutr. 2022, 15, 1–32. [Google Scholar] [CrossRef]
  8. Yoshioka, Y.; Ohishi, T.; Nakamura, Y.; Fukutomi, R.; Miyoshi, N. Anti-Cancer Effects of Dietary Polyphenols via ROS-Mediated Pathway with Their Modulation of MicroRNAs. Molecules 2022, 27, 3816. [Google Scholar] [CrossRef] [PubMed]
  9. Yang, J.; Cao, Y.; Sun, J.; Zhang, Y. Curcumin Reduces the Expression of Bcl-2 by Upregulating MiR-15a and MiR-16 in MCF-7 Cells. Med. Oncol. 2010, 27, 1114–1118. [Google Scholar] [CrossRef]
  10. Tsang, W.P.; Kwok, T.T. Epigallocatechin Gallate Up-Regulation of MiR-16 and Induction of Apoptosis in Human Cancer Cells. J. Nutr. Biochem. 2010, 21, 140–146. [Google Scholar] [CrossRef]
  11. Sonoki, H.; Sato, T.; Endo, S.; Matsunaga, T.; Yamaguchi, M.; Yamazaki, Y.; Sugatani, J.; Ikari, A. Quercetin Decreases Claudin-2 Expression Mediated by Up-Regulation of MicroRNA MiR-16 in Lung Adenocarcinoma A549 Cells. Nutrients 2015, 7, 4578–4592. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  12. Zhao, J.; Fang, Z.; Zha, Z.; Sun, Q.; Wang, H.; Sun, M.; Qiao, B. Quercetin Inhibits Cell Viability, Migration and Invasion by Regulating MiR-16/HOXA10 Axis in Oral Cancer. Eur. J. Pharmacol. 2019, 847, 11–18. [Google Scholar] [CrossRef] [PubMed]
  13. Hagiwara, K.; Kosaka, N.; Yoshioka, Y.; Takahashi, R.-U.; Takeshita, F.; Ochiya, T. Stilbene Derivatives Promote Ago2-Dependent Tumour-Suppressive MicroRNA Activity. Sci. Rep. 2012, 2, 314. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  14. Azimi, A.; Hagh, M.F.; Talebi, M.; Yousefi, B.; Feizi, A.A.H.p.; Baradaran, B.; Movassaghpour, A.A.; Shamsasenjan, K.; Khanzedeh, T.; Ghaderi, A.H.; et al. Time--and Concentration--Dependent Effects of Resveratrol on MiR 15a and MiR16-1 Expression and Apoptosis in the CCRF-CEM Acute Lymphoblastic Leukemia Cell Line. Asian Pac. J. Cancer Prev. 2015, 16, 6463–6468. [Google Scholar] [CrossRef] [Green Version]
  15. Sun, M.; Estrov, Z.; Ji, Y.; Coombes, K.R.; Harris, D.H.; Kurzrock, R. Curcumin (Diferuloylmethane) Alters the Expression Profiles of MicroRNAs in Human Pancreatic Cancer Cells. Mol. Cancer Ther. 2008, 7, 464–473. [Google Scholar] [CrossRef] [Green Version]
  16. Sreenivasan, S.; Thirumalai, K.; Danda, R.; Krishnakumar, S. Effect of Curcumin on MiRNA Expression in Human Y79 Retinoblastoma Cells. Curr. Eye Res. 2012, 37, 421–428. [Google Scholar] [CrossRef]
  17. Sibbesen, N.A.; Kopp, K.L.; Litvinov, I.V.; Jønson, L.; Willerslev-Olsen, A.; Fredholm, S.; Petersen, D.L.; Nastasi, C.; Krejsgaard, T.; Lindahl, L.M.; et al. Jak3, STAT3, and STAT5 Inhibit Expression of MiR-22, a Novel Tumor Suppressor MicroRNA, in Cutaneous T-Cell Lymphoma. Oncotarget 2015, 6, 20555–20569. [Google Scholar] [CrossRef] [Green Version]
  18. Li, B.-B.; Huang, G.-L.; Li, H.-H.; Kong, X.; He, Z.-W. Epigallocatechin-3-Gallate Modulates MicroRNA Expression Profiles in Human Nasopharyngeal Carcinoma CNE2 Cells. Chin. Med. J. 2017, 130, 93–99. [Google Scholar] [CrossRef]
  19. Zhang, C.; Hao, Y.; Sun, Y.; Liu, P. Quercetin Suppresses the Tumorigenesis of Oral Squamous Cell Carcinoma by Regulating MicroRNA-22/WNT1/β-Catenin Axis. J. Pharmacol. Sci. 2019, 140, 128–136. [Google Scholar] [CrossRef]
  20. Guo, J.; Li, W.; Shi, H.; Xie, X.; Li, L.; Tang, H.; Wu, M.; Kong, Y.; Yang, L.; Gao, J.; et al. Synergistic Effects of Curcumin with Emodin against the Proliferation and Invasion of Breast Cancer Cells through Upregulation of MiR-34a. Mol. Cell. Biochem. 2013, 382, 103–111. [Google Scholar] [CrossRef]
  21. Sun, C.; Zhang, S.; Liu, C.; Liu, X. Curcumin Promoted MiR-34a Expression and Suppressed Proliferation of Gastric Cancer Cells. Cancer Biother. Radiopharm. 2019, 34, 634–641. [Google Scholar] [CrossRef] [PubMed]
  22. Toden, S.; Okugawa, Y.; Buhrmann, C.; Nattamai, D.; Anguiano, E.; Baldwin, N.; Shakibaei, M.; Boland, C.R.; Goel, A. Novel Evidence for Curcumin and Boswellic Acid-Induced Chemoprevention through Regulation of MiR-34a and MiR-27a in Colorectal Cancer. Cancer Prev. Res. 2015, 8, 431–443. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  23. Chakrabarti, M.; Khandkar, M.; Banik, N.L.; Ray, S.K. Alterations in Expression of Specific MicroRNAs by Combination of 4-HPR and EGCG Inhibited Growth of Human Malignant Neuroblastoma Cells. Brain Res. 2012, 1454, 1–13. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  24. Chakrabarti, M.; Ai, W.; Banik, N.L.; Ray, S.K. Overexpression of MiR-7-1 Increases Efficacy of Green Tea Polyphenols for Induction of Apoptosis in Human Malignant Neuroblastoma SH-SY5Y and SK-N-DZ Cells. Neurochem. Res. 2013, 38, 420–432. [Google Scholar] [CrossRef] [PubMed]
  25. Toden, S.; Tran, H.-M.; Tovar-Camargo, O.A.; Okugawa, Y.; Goel, A. Epigallocatechin-3-Gallate Targets Cancer Stem-like Cells and Enhances 5-Fluorouracil Chemosensitivity in Colorectal Cancer. Oncotarget 2016, 7, 16158–16171. [Google Scholar] [CrossRef] [Green Version]
  26. Mostafa, S.M.; Gamal-Eldeen, A.M.; Maksoud, N.A.E.; Fahmi, A.A. Epigallocatechin Gallate-Capped Gold Nanoparticles Enhanced the Tumor Suppressors Let-7a and MiR-34a in Hepatocellular Carcinoma Cells. An. Acad. Bras. Cienc. 2020, 92, e20200574. [Google Scholar] [CrossRef]
  27. Hsieh, P.-L.; Liao, Y.-W.; Hsieh, C.-W.; Chen, P.-N.; Yu, C.-C. Soy Isoflavone Genistein Impedes Cancer Stemness and Mesenchymal Transition in Head and Neck Cancer through Activating MiR-34a/RTCB Axis. Nutrients 2020, 12, 1924. [Google Scholar] [CrossRef]
  28. Xia, J.; Duan, Q.; Ahmad, A.; Bao, B.; Banerjee, S.; Shi, Y.; Ma, J.; Geng, J.; Chen, Z.; Rahman, K.M.W.; et al. Genistein Inhibits Cell Growth and Induces Apoptosis through Up-Regulation of MiR-34a in Pancreatic Cancer Cells. Curr. Drug Targets 2012, 13, 1750–1756. [Google Scholar] [CrossRef]
  29. Chiyomaru, T.; Yamamura, S.; Fukuhara, S.; Yoshino, H.; Kinoshita, T.; Majid, S.; Saini, S.; Chang, I.; Tanaka, Y.; Enokida, H.; et al. Genistein Inhibits Prostate Cancer Cell Growth by Targeting MiR-34a and Oncogenic HOTAIR. PLoS ONE 2013, 8, e70372. [Google Scholar] [CrossRef] [PubMed]
  30. Otsuka, K.; Yamamoto, Y.; Ochiya, T. Regulatory Role of Resveratrol, a MicroRNA-Controlling Compound, in HNRNPA1 Expression, Which Is Associated with Poor Prognosis in Breast Cancer. Oncotarget 2018, 9, 24718–24730. [Google Scholar] [CrossRef]
  31. Kumazaki, M.; Noguchi, S.; Yasui, Y.; Iwasaki, J.; Shinohara, H.; Yamada, N.; Akao, Y. Anti-Cancer Effects of Naturally Occurring Compounds through Modulation of Signal Transduction and MiRNA Expression in Human Colon Cancer Cells. J. Nutr. Biochem. 2013, 24, 1849–1858. [Google Scholar] [CrossRef] [PubMed]
  32. Yao, S.; Gao, M.; Wang, Z.; Wang, W.; Zhan, L.; Wei, B. Upregulation of MicroRNA-34a Sensitizes Ovarian Cancer Cells to Resveratrol by Targeting Bcl-2. Yonsei Med. J. 2021, 62, 691–701. [Google Scholar] [CrossRef] [PubMed]
  33. Toden, S.; Okugawa, Y.; Jascur, T.; Wodarz, D.; Komarova, N.L.; Buhrmann, C.; Shakibaei, M.; Boland, C.R.; Goel, A. Curcumin Mediates Chemosensitization to 5-Fluorouracil through MiRNA-Induced Suppression of Epithelial-to-Mesenchymal Transition in Chemoresistant Colorectal Cancer. Carcinogenesis 2015, 36, 355–367. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  34. Gordon, M.W.; Yan, F.; Zhong, X.; Mazumder, P.B.; Xu-Monette, Z.Y.; Zou, D.; Young, K.H.; Ramos, K.S.; Li, Y. Regulation of P53-Targeting MicroRNAs by Polycyclic Aromatic Hydrocarbons: Implications in the Etiology of Multiple Myeloma. Mol. Carcinog. 2015, 54, 1060–1069. [Google Scholar] [CrossRef] [Green Version]
  35. Chiyomaru, T.; Fukuhara, S.; Saini, S.; Majid, S.; Deng, G.; Shahryari, V.; Chang, I.; Tanaka, Y.; Enokida, H.; Nakagawa, M.; et al. Long Non-Coding RNA HOTAIR Is Targeted and Regulated by MiR-141 in Human Cancer Cells. J. Biol. Chem. 2014, 289, 12550–12565. [Google Scholar] [CrossRef] [Green Version]
  36. Tahmasebi Mirgani, M.; Isacchi, B.; Sadeghizadeh, M.; Marra, F.; Bilia, A.R.; Mowla, S.J.; Najafi, F.; Babaei, E. Dendrosomal Curcumin Nanoformulation Downregulates Pluripotency Genes via MiR-145 Activation in U87MG Glioblastoma Cells. Int. J. Nanomed. 2014, 9, 403–417. [Google Scholar] [CrossRef] [Green Version]
  37. Liu, T.; Chi, H.; Chen, J.; Chen, C.; Huang, Y.; Xi, H.; Xue, J.; Si, Y. Curcumin Suppresses Proliferation and in Vitro Invasion of Human Prostate Cancer Stem Cells by CeRNA Effect of MiR-145 and LncRNA-ROR. Gene 2017, 631, 29–38. [Google Scholar] [CrossRef]
  38. Wei, D.; Yang, L.; Lv, B.; Chen, L. Genistein Suppresses Retinoblastoma Cell Viability and Growth and Induces Apoptosis by Upregulating MiR-145 and Inhibiting Its Target ABCE1. Mol. Vis. 2017, 23, 385–394. [Google Scholar]
  39. Zhou, J.; Gong, J.; Ding, C.; Chen, G. Quercetin Induces the Apoptosis of Human Ovarian Carcinoma Cells by Upregulating the Expression of MicroRNA-145. Mol. Med. Rep. 2015, 12, 3127–3131. [Google Scholar] [CrossRef] [Green Version]
  40. Sachdeva, M.; Liu, Q.; Cao, J.; Lu, Z.; Mo, Y.-Y. Negative Regulation of MiR-145 by C/EBP-β through the Akt Pathway in Cancer Cells. Nucleic Acids Res. 2012, 40, 6683–6692. [Google Scholar] [CrossRef] [Green Version]
  41. Wu, H.; Liu, Q.; Cai, T.; Chen, Y.-D.; Wang, Z.-F. Induction of MicroRNA-146a Is Involved in Curcumin-Mediated Enhancement of Temozolomide Cytotoxicity against Human Glioblastoma. Mol. Med. Rep. 2015, 12, 5461–5466. [Google Scholar] [CrossRef] [PubMed]
  42. Li, Y.; Vandenboom, T.G.; Wang, Z.; Kong, D.; Ali, S.; Philip, P.A.; Sarkar, F.H. MiR-146a Suppresses Invasion of Pancreatic Cancer Cells. Cancer Res. 2010, 70, 1486–1495. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  43. Tao, S.-F.; He, H.-F.; Chen, Q. Quercetin Inhibits Proliferation and Invasion Acts by Up-Regulating MiR-146a in Human Breast Cancer Cells. Mol. Cell. Biochem. 2015, 402, 93–100. [Google Scholar] [CrossRef] [PubMed]
  44. Soubani, O.; Ali, A.S.; Logna, F.; Ali, S.; Philip, P.A.; Sarkar, F.H. Re-Expression of MiR-200 by Novel Approaches Regulates the Expression of PTEN and MT1-MMP in Pancreatic Cancer. Carcinogenesis 2012, 33, 1563–1571. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  45. Karimi Dermani, F.; Saidijam, M.; Amini, R.; Mahdavinezhad, A.; Heydari, K.; Najafi, R. Resveratrol Inhibits Proliferation, Invasion, and Epithelial-Mesenchymal Transition by Increasing MiR-200c Expression in HCT-116 Colorectal Cancer Cells. J. Cell. Biochem. 2017, 118, 1547–1555. [Google Scholar] [CrossRef]
  46. Huang, S.; Wang, L.-L.; Xue, N.-N.; Li, C.; Guo, H.-H.; Ren, T.-K.; Zhan, Y.; Li, W.-B.; Zhang, J.; Chen, X.-G.; et al. Chlorogenic Acid Effectively Treats Cancers through Induction of Cancer Cell Differentiation. Theranostics 2019, 9, 6745–6763. [Google Scholar] [CrossRef]
  47. Gandhy, S.U.; Kim, K.; Larsen, L.; Rosengren, R.J.; Safe, S. Curcumin and Synthetic Analogs Induce Reactive Oxygen Species and Decreases Specificity Protein (Sp) Transcription Factors by Targeting MicroRNAs. BMC Cancer 2012, 12, 564. [Google Scholar] [CrossRef] [Green Version]
  48. Mirzaaghaei, S.; Foroughmand, A.M.; Saki, G.; Shafiei, M. Combination of Epigallocatechin-3-Gallate and Silibinin: A Novel Approach for Targeting Both Tumor and Endothelial Cells. ACS Omega 2019, 4, 8421–8430. [Google Scholar] [CrossRef]
  49. Dhar, S.; Kumar, A.; Rimando, A.M.; Zhang, X.; Levenson, A.S. Resveratrol and Pterostilbene Epigenetically Restore PTEN Expression by Targeting OncomiRs of the MiR-17 Family in Prostate Cancer. Oncotarget 2015, 6, 27214–27226. [Google Scholar] [CrossRef] [Green Version]
  50. Dhar, S.; Hicks, C.; Levenson, A.S. Resveratrol and Prostate Cancer: Promising Role for MicroRNAs. Mol. Nutr. Food Res. 2011, 55, 1219–1229. [Google Scholar] [CrossRef]
  51. Wang, Y.; Yang, F.; Xue, J.; Zhou, X.; Luo, L.; Ma, Q.; Chen, Y.-F.; Zhang, J.; Zhang, S.-L.; Zhao, L. Antischistosomiasis Liver Fibrosis Effects of Chlorogenic Acid through IL-13/MiR-21/Smad7 Signaling Interactions In Vivo and In Vitro. Antimicrob. Agents Chemother. 2017, 61, e01347-16. [Google Scholar] [CrossRef] [PubMed]
  52. Mudduluru, G.; George-William, J.N.; Muppala, S.; Asangani, I.A.; Kumarswamy, R.; Nelson, L.D.; Allgayer, H. Curcumin Regulates MiR-21 Expression and Inhibits Invasion and Metastasis in Colorectal Cancer. Biosci. Rep. 2011, 31, 185–197. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  53. Subramaniam, D.; Ponnurangam, S.; Ramamoorthy, P.; Standing, D.; Battafarano, R.J.; Anant, S.; Sharma, P. Curcumin Induces Cell Death in Esophageal Cancer Cells through Modulating Notch Signaling. PLoS ONE 2012, 7, e30590. [Google Scholar] [CrossRef] [PubMed]
  54. Zhang, W.; Bai, W.; Zhang, W. MiR-21 Suppresses the Anticancer Activities of Curcumin by Targeting PTEN Gene in Human Non-Small Cell Lung Cancer A549 Cells. Clin. Transl. Oncol. 2014, 16, 708–713. [Google Scholar] [CrossRef]
  55. Taverna, S.; Giallombardo, M.; Pucci, M.; Flugy, A.; Manno, M.; Raccosta, S.; Rolfo, C.; De Leo, G.; Alessandro, R. Curcumin Inhibits in Vitro and in Vivo Chronic Myelogenous Leukemia Cells Growth: A Possible Role for Exosomal Disposal of MiR-21. Oncotarget 2015, 6, 21918–21933. [Google Scholar] [CrossRef] [Green Version]
  56. Yallapu, M.M.; Khan, S.; Maher, D.M.; Ebeling, M.C.; Sundram, V.; Chauhan, N.; Ganju, A.; Balakrishna, S.; Gupta, B.K.; Zafar, N.; et al. Anti-Cancer Activity of Curcumin Loaded Nanoparticles in Prostate Cancer. Biomaterials 2014, 35, 8635–8648. [Google Scholar] [CrossRef] [Green Version]
  57. Fix, L.N.; Shah, M.; Efferth, T.; Farwell, M.A.; Zhang, B. MicroRNA Expression Profile of MCF-7 Human Breast Cancer Cells and the Effect of Green Tea Polyphenon-60. Cancer Genom. Proteom. 2010, 7, 261–277. [Google Scholar]
  58. Siddiqui, I.A.; Asim, M.; Hafeez, B.B.; Adhami, V.M.; Tarapore, R.S.; Mukhtar, H. Green Tea Polyphenol EGCG Blunts Androgen Receptor Function in Prostate Cancer. FASEB J. 2011, 25, 1198–1207. [Google Scholar] [CrossRef] [Green Version]
  59. Zaman, M.S.; Shahryari, V.; Deng, G.; Thamminana, S.; Saini, S.; Majid, S.; Chang, I.; Hirata, H.; Ueno, K.; Yamamura, S.; et al. Up-Regulation of MicroRNA-21 Correlates with Lower Kidney Cancer Survival. PLoS ONE 2012, 7, e31060. [Google Scholar] [CrossRef]
  60. Tili, E.; Michaille, J.-J.; Alder, H.; Volinia, S.; Delmas, D.; Latruffe, N.; Croce, C.M. Resveratrol Modulates the Levels of MicroRNAs Targeting Genes Encoding Tumor-Suppressors and Effectors of TGFβ Signaling Pathway in SW480 Cells. Biochem. Pharmacol. 2010, 80, 2057–2065. [Google Scholar] [CrossRef] [Green Version]
  61. Sheth, S.; Jajoo, S.; Kaur, T.; Mukherjea, D.; Sheehan, K.; Rybak, L.P.; Ramkumar, V. Resveratrol Reduces Prostate Cancer Growth and Metastasis by Inhibiting the Akt/MicroRNA-21 Pathway. PLoS ONE 2012, 7, e51655. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  62. Liu, P.; Liang, H.; Xia, Q.; Li, P.; Kong, H.; Lei, P.; Wang, S.; Tu, Z. Resveratrol Induces Apoptosis of Pancreatic Cancers Cells by Inhibiting MiR-21 Regulation of BCL-2 Expression. Clin. Transl. Oncol. 2013, 15, 741–746. [Google Scholar] [CrossRef] [PubMed]
  63. Li, H.; Jia, Z.; Li, A.; Jenkins, G.; Yang, X.; Hu, J.; Guo, W. Resveratrol Repressed Viability of U251 Cells by MiR-21 Inhibiting of NF-ΚB Pathway. Mol. Cell. Biochem. 2013, 382, 137–143. [Google Scholar] [CrossRef] [PubMed]
  64. Zhou, C.; Ding, J.; Wu, Y. Resveratrol Induces Apoptosis of Bladder Cancer Cells via MiR-21 Regulation of the Akt/Bcl-2 Signaling Pathway. Mol. Med. Rep. 2014, 9, 1467–1473. [Google Scholar] [CrossRef] [Green Version]
  65. Zan, L.; Chen, Q.; Zhang, L.; Li, X. Epigallocatechin Gallate (EGCG) Suppresses Growth and Tumorigenicity in Breast Cancer Cells by Downregulation of MiR-25. Bioengineered 2019, 10, 374–382. [Google Scholar] [CrossRef] [Green Version]
  66. Noratto, G.D.; Jutooru, I.; Safe, S.; Angel-Morales, G.; Mertens-Talcott, S.U. The Drug Resistance Suppression Induced by Curcuminoids in Colon Cancer SW-480 Cells Is Mediated by Reactive Oxygen Species-Induced Disruption of the MicroRNA-27a-ZBTB10-Sp Axis. Mol. Nutr. Food Res. 2013, 57, 1638–1648. [Google Scholar] [CrossRef]
  67. Xia, J.; Cheng, L.; Mei, C.; Ma, J.; Shi, Y.; Zeng, F.; Wang, Z.; Wang, Z. Genistein Inhibits Cell Growth and Invasion through Regulation of MiR-27a in Pancreatic Cancer Cells. Curr. Pharm. Des. 2014, 20, 5348–5353. [Google Scholar] [CrossRef]
  68. Xu, L.; Xiang, J.; Shen, J.; Zou, X.; Zhai, S.; Yin, Y.; Li, P.; Wang, X.; Sun, Q. Oncogenic MicroRNA-27a Is a Target for Genistein in Ovarian Cancer Cells. Anticancer Agents Med. Chem. 2013, 13, 1126–1132. [Google Scholar] [CrossRef]
  69. Sun, Q.; Cong, R.; Yan, H.; Gu, H.; Zeng, Y.; Liu, N.; Chen, J.; Wang, B. Genistein Inhibits Growth of Human Uveal Melanoma Cells and Affects MicroRNA-27a and Target Gene Expression. Oncol. Rep. 2009, 22, 563–567. [Google Scholar] [CrossRef] [Green Version]
  70. Singh, B.; Shoulson, R.; Chatterjee, A.; Ronghe, A.; Bhat, N.K.; Dim, D.C.; Bhat, H.K. Resveratrol Inhibits Estrogen-Induced Breast Carcinogenesis through Induction of NRF2-Mediated Protective Pathways. Carcinogenesis 2014, 35, 1872–1880. [Google Scholar] [CrossRef] [Green Version]
  71. Zeng, J.; Zhang, D.; Wan, X.; Bai, Y.; Yuan, C.; Wang, T.; Yuan, D.; Zhang, C.; Liu, C. Chlorogenic Acid Suppresses MiR-155 and Ameliorates Ulcerative Colitis through the NF-ΚB/NLRP3 Inflammasome Pathway. Mol. Nutr. Food Res. 2020, 64, 1901329–2000452. [Google Scholar] [CrossRef]
  72. Ma, F.; Liu, F.; Ding, L.; You, M.; Yue, H.; Zhou, Y.; Hou, Y. Anti-Inflammatory Effects of Curcumin Are Associated with down Regulating MicroRNA-155 in LPS-Treated Macrophages and Mice. Pharm. Biol. 2017, 55, 1263–1273. [Google Scholar] [CrossRef] [PubMed]
  73. de la Parra, C.; Castillo-Pichardo, L.; Cruz-Collazo, A.; Cubano, L.; Redis, R.; Calin, G.A.; Dharmawardhane, S. Soy Isoflavone Genistein-Mediated Downregulation of MiR-155 Contributes to the Anticancer Effects of Genistein. Nutr. Cancer 2016, 68, 154–164. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  74. Boesch-Saadatmandi, C.; Loboda, A.; Wagner, A.E.; Stachurska, A.; Jozkowicz, A.; Dulak, J.; Döring, F.; Wolffram, S.; Rimbach, G. Effect of Quercetin and Its Metabolites Isorhamnetin and Quercetin-3-Glucuronide on Inflammatory Gene Expression: Role of MiR-155. J. Nutr. Biochem. 2011, 22, 293–299. [Google Scholar] [CrossRef] [PubMed]
  75. Tili, E.; Michaille, J.-J.; Adair, B.; Alder, H.; Limagne, E.; Taccioli, C.; Ferracin, M.; Delmas, D.; Latruffe, N.; Croce, C.M. Resveratrol Decreases the Levels of MiR-155 by Upregulating MiR-663, a MicroRNA Targeting JunB and JunD. Carcinogenesis 2010, 31, 1561–1566. [Google Scholar] [CrossRef]
  76. Zhang, S.; Tang, D.; Zang, W.; Yin, G.; Dai, J.; Sun, Y.U.; Yang, Z.; Hoffman, R.M.; Guo, X. Synergistic Inhibitory Effect of Traditional Chinese Medicine Astragaloside IV and Curcumin on Tumor Growth and Angiogenesis in an Orthotopic Nude-Mouse Model of Human Hepatocellular Carcinoma. Anticancer Res. 2017, 37, 465–473. [Google Scholar] [CrossRef] [Green Version]
  77. Allegri, L.; Rosignolo, F.; Mio, C.; Filetti, S.; Baldan, F.; Damante, G. Effects of Nutraceuticals on Anaplastic Thyroid Cancer Cells. J. Cancer Res. Clin. Oncol. 2018, 144, 285–294. [Google Scholar] [CrossRef]
  78. Chen, Y.; Zaman, M.S.; Deng, G.; Majid, S.; Saini, S.; Liu, J.; Tanaka, Y.; Dahiya, R. MicroRNAs 221/222 and Genistein-Mediated Regulation of ARHI Tumor Suppressor Gene in Prostate Cancer. Cancer Prev. Res. 2011, 4, 76–86. [Google Scholar] [CrossRef] [Green Version]
  79. Sarkar, S.; Dubaybo, H.; Ali, S.; Goncalves, P.; Kollepara, S.L.; Sethi, S.; Philip, P.A.; Li, Y. Down-Regulation of MiR-221 Inhibits Proliferation of Pancreatic Cancer Cells through up-Regulation of PTEN, P27(Kip1), P57(Kip2), and PUMA. Am. J. Cancer Res. 2013, 3, 465–477. [Google Scholar]
  80. Ma, J.; Fang, B.; Zeng, F.; Pang, H.; Zhang, J.; Shi, Y.; Wu, X.; Cheng, L.; Ma, C.; Xia, J.; et al. Curcumin Inhibits Cell Growth and Invasion through Up-Regulation of MiR-7 in Pancreatic Cancer Cells. Toxicol. Lett. 2014, 231, 82–91. [Google Scholar] [CrossRef] [PubMed]
  81. Feng, S.; Wang, Y.; Zhang, R.; Yang, G.; Liang, Z.; Wang, Z.; Zhang, G. Curcumin Exerts Its Antitumor Activity through Regulation of MiR-7/Skp2/P21 in Nasopharyngeal Carcinoma Cells. OncoTargets Ther. 2017, 10, 2377–2388. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  82. Zhao, S.-F.; Zhang, X.; Zhang, X.-J.; Shi, X.-Q.; Yu, Z.-J.; Kan, Q.-C. Induction of MicroRNA-9 Mediates Cytotoxicity of Curcumin against SKOV3 Ovarian Cancer Cells. Asian Pac. J. Cancer Prev. 2014, 15, 3363–3368. [Google Scholar] [CrossRef] [PubMed]
  83. Xiao, C.; Wang, L.; Zhu, L.; Zhang, C.; Zhou, J. Curcumin Inhibits Oral Squamous Cell Carcinoma SCC-9 Cells Proliferation by Regulating MiR-9 Expression. Biochem. Biophys. Res. Commun. 2014, 454, 576–580. [Google Scholar] [CrossRef] [PubMed]
  84. Gao, S.; Yang, J.; Chen, C.; Chen, J.; Ye, L.; Wang, L.; Wu, J.; Xing, C.; Yu, K. Pure Curcumin Decreases the Expression of WT1 by Upregulation of MiR-15a and MiR-16-1 in Leukemic Cells. J. Exp. Clin. Cancer Res. 2012, 31, 27. [Google Scholar] [CrossRef] [Green Version]
  85. Kang, T.; Sun, W.-L.; Lu, X.-F.; Wang, X.-L.; Jiang, L. MiR-28-5p Mediates the Anti-Proliferative and pro-Apoptotic Effects of Curcumin on Human Diffuse Large B-Cell Lymphoma Cells. J. Int. Med. Res. 2020, 48, 300060520943792. [Google Scholar] [CrossRef]
  86. Zamani, M.; Sadeghizadeh, M.; Behmanesh, M.; Najafi, F. Dendrosomal Curcumin Increases Expression of the Long Non-Coding RNA Gene MEG3 via up-Regulation of Epi-MiRs in Hepatocellular Cancer. Phytomedicine 2015, 22, 961–967. [Google Scholar] [CrossRef] [PubMed]
  87. Lu, Y.; Wang, J.; Liu, L.; Yu, L.; Zhao, N.; Zhou, X.; Lu, X. Curcumin Increases the Sensitivity of Paclitaxel-Resistant NSCLC Cells to Paclitaxel through MicroRNA-30c-Mediated MTA1 Reduction. Tumour Biol. 2017, 39, 1010428317698353. [Google Scholar] [CrossRef] [Green Version]
  88. Zhang, P.; Bai, H.; Liu, G.; Wang, H.; Chen, F.; Zhang, B.; Zeng, P.; Wu, C.; Peng, C.; Huang, C.; et al. MicroRNA-33b, Upregulated by EF24, a Curcumin Analog, Suppresses the Epithelial-to-Mesenchymal Transition (EMT) and Migratory Potential of Melanoma Cells by Targeting HMGA2. Toxicol. Lett. 2015, 234, 151–161. [Google Scholar] [CrossRef]
  89. Sun, Q.; Zhang, W.; Guo, Y.; Li, Z.; Chen, X.; Wang, Y.; Du, Y.; Zang, W.; Zhao, G. Curcumin Inhibits Cell Growth and Induces Cell Apoptosis through Upregulation of MiR-33b in Gastric Cancer. Tumour Biol. 2016, 37, 13177–13184. [Google Scholar] [CrossRef] [PubMed]
  90. Liu, W.-L.; Chang, J.-M.; Chong, I.-W.; Hung, Y.-L.; Chen, Y.-H.; Huang, W.-T.; Kuo, H.-F.; Hsieh, C.-C.; Liu, P.-L. Curcumin Inhibits LIN-28A through the Activation of MiRNA-98 in the Lung Cancer Cell Line A549. Molecules 2017, 22, 929. [Google Scholar] [CrossRef] [Green Version]
  91. Li, Y.; Sun, W.; Han, N.; Zou, Y.; Yin, D. Curcumin Inhibits Proliferation, Migration, Invasion and Promotes Apoptosis of Retinoblastoma Cell Lines through Modulation of MiR-99a and JAK/STAT Pathway. BMC Cancer 2018, 18, 1230. [Google Scholar] [CrossRef] [Green Version]
  92. Bao, B.; Ali, S.; Banerjee, S.; Wang, Z.; Logna, F.; Azmi, A.S.; Kong, D.; Ahmad, A.; Li, Y.; Padhye, S.; et al. Curcumin Analogue CDF Inhibits Pancreatic Tumor Growth by Switching on Suppressor MicroRNAs and Attenuating EZH2 Expression. Cancer Res. 2012, 72, 335–345. [Google Scholar] [CrossRef] [Green Version]
  93. Wu, G.-Q.; Chai, K.-Q.; Zhu, X.-M.; Jiang, H.; Wang, X.; Xue, Q.; Zheng, A.-H.; Zhou, H.-Y.; Chen, Y.; Chen, X.-C.; et al. Anti-Cancer Effects of Curcumin on Lung Cancer through the Inhibition of EZH2 and NOTCH1. Oncotarget 2016, 7, 26535–26550. [Google Scholar] [CrossRef] [PubMed]
  94. Wu, C.; Ruan, T.; Liu, W.; Zhu, X.; Pan, J.; Lu, W.; Yan, C.; Tao, K.; Zhang, W.; Zhang, C. Effect and Mechanism of Curcumin on EZH2-MiR-101 Regulatory Feedback Loop in Multiple Myeloma. Curr. Pharm. Des. 2018, 24, 564–575. [Google Scholar] [CrossRef] [PubMed]
  95. Zhao, J.; Pan, Y.; Li, X.; Zhang, X.; Xue, Y.; Wang, T.; Zhao, S.; Hou, Y. Dihydroartemisinin and Curcumin Synergistically Induce Apoptosis in SKOV3 Cells Via Upregulation of MiR-124 Targeting Midkine. Cell. Physiol. Biochem. 2017, 43, 589–601. [Google Scholar] [CrossRef] [PubMed]
  96. Chen, P.; Wang, H.; Yang, F.; Chen, H.; He, W.; Wang, J. Curcumin Promotes Osteosarcoma Cell Death by Activating MiR-125a/ERRα Signal Pathway. J. Cell. Biochem. 2017, 118, 74–81. [Google Scholar] [CrossRef]
  97. Yu, D.; An, F.; He, X.; Cao, X. Curcumin Inhibits the Proliferation and Invasion of Human Osteosarcoma Cell Line MG-63 by Regulating MiR-138. Int. J. Clin. Exp. Pathol. 2015, 8, 14946–14952. [Google Scholar]
  98. Qiu, B.; Xu, X.; Yi, P.; Hao, Y. Curcumin Reinforces MSC-Derived Exosomes in Attenuating Osteoarthritis via Modulating the MiR-124/NF-KB and MiR-143/ROCK1/TLR9 Signalling Pathways. J. Cell. Mol. Med. 2020, 24, 10855–10865. [Google Scholar] [CrossRef]
  99. Cao, H.; Yu, H.; Feng, Y.; Chen, L.; Liang, F. Curcumin Inhibits Prostate Cancer by Targeting PGK1 in the FOXD3/MiR-143 Axis. Cancer Chemother. Pharmacol. 2017, 79, 985–994. [Google Scholar] [CrossRef]
  100. Liu, J.; Li, M.; Wang, Y.; Luo, J. Curcumin Sensitizes Prostate Cancer Cells to Radiation Partly via Epigenetic Activation of MiR-143 and MiR-143 Mediated Autophagy Inhibition. J. Drug Target. 2017, 25, 645–652. [Google Scholar] [CrossRef]
  101. Kronski, E.; Fiori, M.E.; Barbieri, O.; Astigiano, S.; Mirisola, V.; Killian, P.H.; Bruno, A.; Pagani, A.; Rovera, F.; Pfeffer, U.; et al. MiR181b Is Induced by the Chemopreventive Polyphenol Curcumin and Inhibits Breast Cancer Metastasis via Down-Regulation of the Inflammatory Cytokines CXCL1 and -2. Mol. Oncol. 2014, 8, 581–595. [Google Scholar] [CrossRef] [PubMed]
  102. Ye, M.; Zhang, J.; Zhang, J.; Miao, Q.; Yao, L.; Zhang, J. Curcumin Promotes Apoptosis by Activating the P53-MiR-192-5p/215-XIAP Pathway in Non-Small Cell Lung Cancer. Cancer Lett. 2015, 357, 196–205. [Google Scholar] [CrossRef] [PubMed]
  103. Jin, H.; Qiao, F.; Wang, Y.; Xu, Y.; Shang, Y. Curcumin Inhibits Cell Proliferation and Induces Apoptosis of Human Non-Small Cell Lung Cancer Cells through the Upregulation of MiR-192-5p and Suppression of PI3K/Akt Signaling Pathway. Oncol. Rep. 2015, 34, 2782–2789. [Google Scholar] [CrossRef] [Green Version]
  104. Pan, Y.; Sun, Y.; Liu, Z.; Zhang, C. MiR-192-5p Upregulation Mediates the Suppression of Curcumin in Human NSCLC Cell Proliferation, Migration and Invasion by Targeting C-Myc and Inactivating the Wnt/Β-catenin Signaling Pathway. Mol. Med. Rep. 2020, 22, 1594–1604. [Google Scholar] [CrossRef]
  105. Wang, N.; Feng, T.; Liu, X.; Liu, Q. Curcumin Inhibits Migration and Invasion of Non-Small Cell Lung Cancer Cells through up-Regulation of MiR-206 and Suppression of PI3K/AKT/MTOR Signaling Pathway. Acta Pharm. 2020, 70, 399–409. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  106. Yang, D.; Li, Y.; Zhao, D. Curcumin Induces Apoptotic Cell Death in Human Pancreatic Cancer Cells via the MiR-340/XIAP Signaling Pathway. Oncol. Lett. 2017, 14, 1811–1816. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  107. Xu, X.; Zhang, X.; Zhang, Y.; Wang, Z. Curcumin Suppresses the Malignancy of Non-Small Cell Lung Cancer by Modulating the Circ-PRKCA/MiR-384/ITGB1 Pathway. Biomed. Pharmacother. 2021, 138, 111439. [Google Scholar] [CrossRef]
  108. Li, B.; Shi, C.; Li, B.; Zhao, J.-M.; Wang, L. The Effects of Curcumin on HCT-116 Cells Proliferation and Apoptosis via the MiR-491/PEG10 Pathway. J. Cell. Biochem. 2018, 119, 3091–3098. [Google Scholar] [CrossRef]
  109. Fan, H.; Shao, M.; Huang, S.; Liu, Y.; Liu, J.; Wang, Z.; Diao, J.; Liu, Y.; Tong, L.I.; Fan, Q. MiR-593 Mediates Curcumin-Induced Radiosensitization of Nasopharyngeal Carcinoma Cells via MDR1. Oncol. Lett. 2016, 11, 3729–3734. [Google Scholar] [CrossRef] [Green Version]
  110. Zhang, S.; Al-Maghout, T.; Bissinger, R.; Zeng, N.; Pelzl, L.; Salker, M.S.; Cheng, A.; Singh, Y.; Lang, F. Epigallocatechin-3-Gallate (EGCG) up-Regulates MiR-15b Expression Thus Attenuating Store Operated Calcium Entry (SOCE) into Murine CD4+ T Cells and Human Leukaemic T Cell Lymphoblasts. Oncotarget 2017, 8, 89500–89514. [Google Scholar] [CrossRef] [Green Version]
  111. Zhao, Y.; Chen, X.; Jiang, J.; Wan, X.; Wang, Y.; Xu, P. Epigallocatechin Gallate Reverses Gastric Cancer by Regulating the Long Noncoding RNA LINC00511/MiR-29b/KDM2A Axis. Biochim. Biophys. Acta Mol. Basis Dis. 2020, 1866, 165856. [Google Scholar] [CrossRef] [PubMed]
  112. Jiang, P.; Xu, C.; Chen, L.; Chen, A.; Wu, X.; Zhou, M.; Haq, I.U.; Mariyam, Z.; Feng, Q. Epigallocatechin-3-Gallate Inhibited Cancer Stem Cell-like Properties by Targeting Hsa-Mir-485-5p/RXRα in Lung Cancer. J. Cell. Biochem. 2018, 119, 8623–8635. [Google Scholar] [CrossRef] [PubMed]
  113. Yamada, S.; Tsukamoto, S.; Huang, Y.; Makio, A.; Kumazoe, M.; Yamashita, S.; Tachibana, H. Epigallocatechin-3-O-Gallate up-Regulates MicroRNA-Let-7b Expression by Activating 67-KDa Laminin Receptor Signaling in Melanoma Cells. Sci. Rep. 2016, 6, 19225. [Google Scholar] [CrossRef] [Green Version]
  114. Chiyomaru, T.; Yamamura, S.; Fukuhara, S.; Hidaka, H.; Majid, S.; Saini, S.; Arora, S.; Deng, G.; Shahryari, V.; Chang, I.; et al. Genistein Up-Regulates Tumor Suppressor MicroRNA-574-3p in Prostate Cancer. PLoS ONE 2013, 8, e58929. [Google Scholar] [CrossRef] [PubMed]
  115. Ma, C.-H.; Zhang, Y.-X.; Tang, L.-H.; Yang, X.-J.; Cui, W.-M.; Han, C.-C.; Ji, W.-Y. MicroRNA-1469, a P53-Responsive MicroRNA Promotes Genistein Induced Apoptosis by Targeting Mcl1 in Human Laryngeal Cancer Cells. Biomed. Pharmacother. 2018, 106, 665–671. [Google Scholar] [CrossRef]
  116. Asama, H.; Suzuki, R.; Hikichi, T.; Takagi, T.; Masamune, A.; Ohira, H. MicroRNA Let-7d Targets Thrombospondin-1 and Inhibits the Activation of Human Pancreatic Stellate Cells. Pancreatology 2019, 19, 196–203. [Google Scholar] [CrossRef]
  117. Wang, Y.; Chen, X.; Li, J.; Xia, C. Quercetin Antagonizes Esophagus Cancer by Modulating MiR-1-3p/TAGLN2 Pathway-Dependent Growth and Metastasis. Nutr. Cancer 2022, 74, 1872–1881. [Google Scholar] [CrossRef]
  118. Wang, Q.; Chen, Y.; Lu, H.; Wang, H.; Feng, H.; Xu, J.; Zhang, B. Quercetin Radiosensitizes Non-Small Cell Lung Cancer Cells through the Regulation of MiR-16-5p/WEE1 Axis. IUBMB Life 2020, 72, 1012–1022. [Google Scholar] [CrossRef]
  119. Chai, R.; Xu, C.; Lu, L.; Liu, X.; Ma, Z. Quercetin Inhibits Proliferation of and Induces Apoptosis in Non-Small-Cell Lung Carcinoma via the LncRNA SNHG7/MiR-34a-5p Pathway. Immunopharmacol. Immunotoxicol. 2021, 43, 693–703. [Google Scholar] [CrossRef]
  120. MacKenzie, T.N.; Mujumdar, N.; Banerjee, S.; Sangwan, V.; Sarver, A.; Vickers, S.; Subramanian, S.; Saluja, A.K. Triptolide Induces the Expression of MiR-142-3p: A Negative Regulator of Heat Shock Protein 70 and Pancreatic Cancer Cell Proliferation. Mol. Cancer Ther. 2013, 12, 1266–1275. [Google Scholar] [CrossRef] [Green Version]
  121. Hu, S.-A.; Cheng, J.; Zhao, W.-H.; Zhao, H.-Y. Quercetin Induces Apoptosis in Meningioma Cells through the MiR-197/IGFBP5 Cascade. Environ. Toxicol. Pharmacol. 2020, 80, 103439. [Google Scholar] [CrossRef] [PubMed]
  122. Nwaeburu, C.C.; Abukiwan, A.; Zhao, Z.; Herr, I. Quercetin-Induced MiR-200b-3p Regulates the Mode of Self-Renewing Divisions in Pancreatic Cancer. Mol. Cancer 2017, 16, 23. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  123. Zhang, X.; Guo, Q.; Chen, J.; Chen, Z. Quercetin Enhances Cisplatin Sensitivity of Human Osteosarcoma Cells by Modulating MicroRNA-217-KRAS Axis. Mol. Cells 2015, 38, 638–642. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  124. Park, S.; Lim, W.; Bazer, F.W.; Whang, K.-Y.; Song, G. Quercetin Inhibits Proliferation of Endometriosis Regulating Cyclin D1 and Its Target MicroRNAs in Vitro and in Vivo. J. Nutr. Biochem. 2019, 63, 87–100. [Google Scholar] [CrossRef] [PubMed]
  125. Chen, L.; Xia, J.-S.; Wu, J.-H.; Chen, Y.-G.; Qiu, C.-J. Quercetin Suppresses Cell Survival and Invasion in Oral Squamous Cell Carcinoma via the MiR-1254/CD36 Cascade in Vitro. Hum. Exp. Toxicol. 2021, 40, 1413–1421. [Google Scholar] [CrossRef]
  126. Shaalan, Y.M.; Handoussa, H.; Youness, R.A.; Assal, R.A.; El-Khatib, A.H.; Linscheid, M.W.; El Tayebi, H.M.; Abdelaziz, A.I. Destabilizing the Interplay between MiR-1275 and IGF2BPs by Tamarix Articulata and Quercetin in Hepatocellular Carcinoma. Nat. Prod. Res. 2018, 32, 2217–2220. [Google Scholar] [CrossRef] [PubMed]
  127. Appari, M.; Babu, K.R.; Kaczorowski, A.; Gross, W.; Herr, I. Sulforaphane, Quercetin and Catechins Complement Each Other in Elimination of Advanced Pancreatic Cancer by MiR-Let-7 Induction and K-Ras Inhibition. Int. J. Oncol. 2014, 45, 1391–1400. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  128. Nwaeburu, C.C.; Bauer, N.; Zhao, Z.; Abukiwan, A.; Gladkich, J.; Benner, A.; Herr, I. Up-Regulation of MicroRNA Let-7c by Quercetin Inhibits Pancreatic Cancer Progression by Activation of Numbl. Oncotarget 2016, 7, 58367–58380. [Google Scholar] [CrossRef] [Green Version]
  129. El-Kott, A.F.; Shati, A.A.; Ali Al-Kahtani, M.; Alharbi, S.A. The Apoptotic Effect of Resveratrol in Ovarian Cancer Cells Is Associated with Downregulation of Galectin-3 and Stimulating MiR-424-3p Transcription. J. Food Biochem. 2019, 43, e13072. [Google Scholar] [CrossRef]
  130. Zhou, W.; Wang, S.; Ying, Y.; Zhou, R.; Mao, P. MiR-196b/MiR-1290 Participate in the Antitumor Effect of Resveratrol via Regulation of IGFBP3 Expression in Acute Lymphoblastic Leukemia. Oncol. Rep. 2017, 37, 1075–1083. [Google Scholar] [CrossRef] [Green Version]
  131. Li, X.; Xie, W.; Xie, C.; Huang, C.; Zhu, J.; Liang, Z.; Deng, F.; Zhu, M.; Zhu, W.; Wu, R.; et al. Curcumin Modulates MiR-19/PTEN/AKT/P53 Axis to Suppress Bisphenol A-Induced MCF-7 Breast Cancer Cell Proliferation. Phytother. Res. 2014, 28, 1553–1560. [Google Scholar] [CrossRef] [PubMed]
  132. Gao, W.; Chan, J.Y.-W.; Wong, T.-S. Curcumin Exerts Inhibitory Effects on Undifferentiated Nasopharyngeal Carcinoma by Inhibiting the Expression of MiR-125a-5p. Clin. Sci. 2014, 127, 571–579. [Google Scholar] [CrossRef]
  133. Dou, H.; Shen, R.; Tao, J.; Huang, L.; Shi, H.; Chen, H.; Wang, Y.; Wang, T. Curcumin Suppresses the Colon Cancer Proliferation by Inhibiting Wnt/β-Catenin Pathways via MiR-130a. Front. Pharmacol. 2017, 8, 877. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  134. Wang, K.; Tan, S.-L.; Lu, Q.; Xu, R.; Cao, J.; Wu, S.-Q.; Wang, Y.-H.; Zhao, X.-K.; Zhong, Z.-H. Curcumin Suppresses MicroRNA-7641-Mediated Regulation of P16 Expression in Bladder Cancer. Am. J. Chin. Med. 2018, 46, 1357–1368. [Google Scholar] [CrossRef] [PubMed]
  135. Jiang, P.; Wu, X.; Wang, X.; Huang, W.; Feng, Q. NEAT1 Upregulates EGCG-Induced CTR1 to Enhance Cisplatin Sensitivity in Lung Cancer Cells. Oncotarget 2016, 7, 43337–43351. [Google Scholar] [CrossRef] [Green Version]
  136. Zaman, M.S.; Thamminana, S.; Shahryari, V.; Chiyomaru, T.; Deng, G.; Saini, S.; Majid, S.; Fukuhara, S.; Chang, I.; Arora, S.; et al. Inhibition of PTEN Gene Expression by Oncogenic MiR-23b-3p in Renal Cancer. PLoS ONE 2012, 7, e50203. [Google Scholar] [CrossRef]
  137. Chiyomaru, T.; Yamamura, S.; Zaman, M.S.; Majid, S.; Deng, G.; Shahryari, V.; Saini, S.; Hirata, H.; Ueno, K.; Chang, I.; et al. Genistein Suppresses Prostate Cancer Growth through Inhibition of Oncogenic MicroRNA-151. PLoS ONE 2012, 7, e43812. [Google Scholar] [CrossRef] [Green Version]
  138. Ma, J.; Cheng, L.; Liu, H.; Zhang, J.; Shi, Y.; Zeng, F.; Miele, L.; Sarkar, F.H.; Xia, J.; Wang, Z. Genistein Down-Regulates MiR-223 Expression in Pancreatic Cancer Cells. Curr. Drug Targets 2013, 14, 1150–1156. [Google Scholar] [CrossRef]
  139. Ma, J.; Zeng, F.; Ma, C.; Pang, H.; Fang, B.; Lian, C.; Yin, B.; Zhang, X.; Wang, Z.; Xia, J. Synergistic Reversal Effect of Epithelial-to-Mesenchymal Transition by MiR-223 Inhibitor and Genistein in Gemcitabine-Resistant Pancreatic Cancer Cells. Am. J. Cancer Res. 2016, 6, 1384–1395. [Google Scholar]
  140. Yu, Y.; Xing, Y.; Zhang, Q.; Zhang, Q.; Huang, S.; Li, X.; Gao, C. Soy Isoflavone Genistein Inhibits Hsa_circ_0031250/MiR-873-5p/FOXM1 Axis to Suppress Non-Small-Cell Lung Cancer Progression. IUBMB Life 2021, 73, 92–107. [Google Scholar] [CrossRef]
  141. Hirata, H.; Hinoda, Y.; Shahryari, V.; Deng, G.; Tanaka, Y.; Tabatabai, Z.L.; Dahiya, R. Genistein Downregulates Onco-MiR-1260b and Upregulates SFRP1 and Smad4 via Demethylation and Histone Modification in Prostate Cancer Cells. Br. J. Cancer 2014, 110, 1645–1654. [Google Scholar] [CrossRef] [PubMed]
  142. Hirata, H.; Ueno, K.; Nakajima, K.; Tabatabai, Z.L.; Hinoda, Y.; Ishii, N.; Dahiya, R. Genistein Downregulates Onco-MiR-1260b and Inhibits Wnt-Signalling in Renal Cancer Cells. Br. J. Cancer 2013, 108, 2070–2078. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  143. C Yilmaz, U.; Bagca, B.G.; Karaca, E.; Durmaz, A.; Durmaz, B.; Aykut, A.; Kayalar, H.; Avci, C.B.; Susluer, S.Y.; Pariltay, E.; et al. Propolis Extract Regulates MicroRNA Expression in Glioblastoma and Brain Cancer Stem Cells. Anticancer Agents Med. Chem. 2022, 22, 378–389. [Google Scholar] [CrossRef] [PubMed]
  144. Ma, B.; Hottiger, M.O. Crosstalk between Wnt/β-Catenin and NF-ΚB Signaling Pathway during Inflammation. Front. Immunol. 2016, 7, 378. [Google Scholar] [CrossRef] [Green Version]
  145. Vallée, A.; Lecarpentier, Y. Crosstalk Between Peroxisome Proliferator-Activated Receptor Gamma and the Canonical WNT/β-Catenin Pathway in Chronic Inflammation and Oxidative Stress During Carcinogenesis. Front. Immunol. 2018, 9, 745. [Google Scholar] [CrossRef] [PubMed]
  146. Lee, S.H.; Hong, H.S.; Liu, Z.X.; Kim, R.H.; Kang, M.K.; Park, N.-H.; Shin, K.-H. TNFα Enhances Cancer Stem Cell-like Phenotype via Notch-Hes1 Activation in Oral Squamous Cell Carcinoma Cells. Biochem. Biophys. Res. Commun. 2012, 424, 58–64. [Google Scholar] [CrossRef] [Green Version]
  147. Zhang, L.; Jiao, M.; Wu, K.; Li, L.; Zhu, G.; Wang, X.; He, D.; Wu, D. TNF-α Induced Epithelial Mesenchymal Transition Increases Stemness Properties in Renal Cell Carcinoma Cells. Int. J. Clin. Exp. Med. 2014, 7, 4951–4958. [Google Scholar]
  148. Chen, Y.; Wen, H.; Zhou, C.; Su, Q.; Lin, Y.; Xie, Y.; Huang, Y.; Qiu, Q.; Lin, J.; Huang, X.; et al. TNF-α Derived from M2 Tumor-Associated Macrophages Promotes Epithelial-Mesenchymal Transition and Cancer Stemness through the Wnt/β-Catenin Pathway in SMMC-7721 Hepatocellular Carcinoma Cells. Exp. Cell Res. 2019, 378, 41–50. [Google Scholar] [CrossRef] [PubMed]
  149. Liu, Y.; Sun, H.; Makabel, B.; Cui, Q.; Li, J.; Su, C.; Ashby, C.R.; Chen, Z.; Zhang, J. The Targeting of Non-coding RNAs by Curcumin: Facts and Hopes for Cancer Therapy (Review). Oncol. Rep. 2019, 42, 20–34. [Google Scholar] [CrossRef]
  150. Gong, Z.; Shen, G.; Huang, C.; Zhang, J.; Ji, J. Downregulation of LncRNA NEAT1 Inhibits the Proliferation of Human Cutaneous Squamous Cell Carcinoma in Vivo and in Vitro. Ann. Transl. Med. 2022, 10, 79. [Google Scholar] [CrossRef]
  151. Dong, P.; Xiong, Y.; Yue, J.; J B Hanley, S.; Kobayashi, N.; Todo, Y.; Watari, H. Exploring LncRNA-Mediated Regulatory Networks in Endometrial Cancer Cells and the Tumor Microenvironment: Advances and Challenges. Cancers 2019, 11, 234. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  152. Tan, S.; Yan, F.; Li, Q.; Liang, Y.; Yu, J.; Li, Z.; He, F.; Li, R.; Li, M. Chlorogenic Acid Promotes Autophagy and Alleviates Salmonella Typhimurium Infection Through the LncRNAGAS5/MiR-23a/PTEN Axis and the P38 MAPK Pathway. Front. Cell Dev. Biol. 2020, 8, 552020. [Google Scholar] [CrossRef] [PubMed]
  153. Gong, W.; Li, J.; Zhu, G.; Wang, Y.; Zheng, G.; Kan, Q. Chlorogenic Acid Relieved Oxidative Stress Injury in Retinal Ganglion Cells through IncRNA-TUG1/Nrf2. Cell Cycle 2019, 18, 1549–1559. [Google Scholar] [CrossRef] [PubMed]
  154. Wang, P.; Long, F.; Lin, H.; Wang, T. Dietary Phytochemicals Targeting Nrf2 for Chemoprevention in Breast Cancer. Food Funct. 2022, 13, 4273–4285. [Google Scholar] [CrossRef] [PubMed]
  155. Qin, J.-J.; Cheng, X.-D.; Zhang, J.; Zhang, W.-D. Dual Roles and Therapeutic Potential of Keap1-Nrf2 Pathway in Pancreatic Cancer: A Systematic Review. Cell Commun. Signal. 2019, 17, 121. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  156. Wang, Q.; Fan, H.; Liu, Y.; Yin, Z.; Cai, H.; Liu, J.; Wang, Z.; Shao, M.; Sun, X.; Diao, J.; et al. Curcumin Enhances the Radiosensitivity in Nasopharyngeal Carcinoma Cells Involving the Reversal of Differentially Expressed Long Non-Coding RNAs. Int. J. Oncol. 2014, 44, 858–864. [Google Scholar] [CrossRef] [PubMed]
  157. Esmatabadi, M.J.D.; Motamedrad, M.; Sadeghizadeh, M. Down-Regulation of LncRNA, GAS5 Decreases Chemotherapeutic Effect of Dendrosomal Curcumin (DNC) in Breast Cancer Cells. Phytomedicine 2018, 42, 56–65. [Google Scholar] [CrossRef] [PubMed]
  158. Zhang, H.; Guo, Y.; Song, Y.; Shang, C. Long Noncoding RNA GAS5 Inhibits Malignant Proliferation and Chemotherapy Resistance to Doxorubicin in Bladder Transitional Cell Carcinoma. Cancer Chemother. Pharmacol. 2017, 79, 49–55. [Google Scholar] [CrossRef] [PubMed]
  159. Novak Kujundzić, R.; Grbesa, I.; Ivkić, M.; Katdare, M.; Gall-Troselj, K. Curcumin Downregulates H19 Gene Transcription in Tumor Cells. J. Cell. Biochem. 2008, 104, 1781–1792. [Google Scholar] [CrossRef] [PubMed]
  160. Liu, G.; Xiang, T.; Wu, Q.-F.; Wang, W.-X. Curcumin Suppresses the Proliferation of Gastric Cancer Cells by Downregulating H19. Oncol. Lett. 2016, 12, 5156–5162. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  161. Cai, J.; Sun, H.; Zheng, B.; Xie, M.; Xu, C.; Zhang, G.; Huang, X.; Zhuang, J. Curcumin Attenuates LncRNA H19-induced Epithelial-mesenchymal Transition In Tamoxifen-resistant Breast Cancer Cells. Mol. Med. Rep. 2021, 23, 13. [Google Scholar] [CrossRef] [PubMed]
  162. Zheng, Z.-H.; You, H.-Y.; Feng, Y.-J.; Zhang, Z.-T. LncRNA KCNQ1OT1 Is a Key Factor in the Reversal Effect of Curcumin on Cisplatin Resistance in the Colorectal Cancer Cells. Mol. Cell. Biochem. 2021, 476, 2575–2585. [Google Scholar] [CrossRef] [PubMed]
  163. Li, Z.; Gao, Y.; Li, L.; Xie, S. Curcumin Inhibits Papillary Thyroid Cancer Cell Proliferation by Regulating LncRNA LINC00691. Anal. Cell. Pathol. 2022, 2022, 5946670. [Google Scholar] [CrossRef]
  164. Garitano-Trojaola, A.; José-Enériz, E.S.; Ezponda, T.; Unfried, J.P.; Carrasco-León, A.; Razquin, N.; Barriocanal, M.; Vilas-Zornoza, A.; Sangro, B.; Segura, V.; et al. Deregulation of Linc-PINT in Acute Lymphoblastic Leukemia Is Implicated in Abnormal Proliferation of Leukemic Cells. Oncotarget 2018, 9, 12842–12852. [Google Scholar] [CrossRef] [PubMed]
  165. Alghanimi, Y.K.; Ghasemian, A. Inhibitory Traits of Dendrosome Curcumin (DNC) on Breast Cancer Compared to Curcumin Single Compound. J. Gastrointest. Cancer 2020, 51, 527–533. [Google Scholar] [CrossRef] [PubMed]
  166. Ye, M.; Gao, R.; Chen, S.; Wei, M.; Wang, J.; Zhang, B.; Wu, S.; Xu, Y.; Wu, P.; Chen, X.; et al. Downregulation of MEG3 and Upregulation of EZH2 Cooperatively Promote Neuroblastoma Progression. J. Cell. Mol. Med. 2022, 26, 2377–2391. [Google Scholar] [CrossRef] [PubMed]
  167. Gao, L.; Shao, T.; Zheng, W.; Ding, J. Curcumin Suppresses Tumor Growth of Gemcitabine-Resistant Non-Small Cell Lung Cancer by Regulating LncRNA-MEG3 and PTEN Signaling. Clin. Transl. Oncol. 2021, 23, 1386–1393. [Google Scholar] [CrossRef] [PubMed]
  168. Yu, H.; Xie, Y.; Zhou, Z.; Wu, Z.; Dai, X.; Xu, B. Curcumin Regulates the Progression of Colorectal Cancer via LncRNA NBR2/AMPK Pathway. Technol. Cancer Res. Treat. 2019, 18, 1533033819870781. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  169. Chen, T.; Yang, P.; Wang, H.; He, Z.-Y. Silence of Long Noncoding RNA PANDAR Switches Low-Dose Curcumin-Induced Senescence to Apoptosis in Colorectal Cancer Cells. OncoTargets Ther. 2017, 10, 483–491. [Google Scholar] [CrossRef] [Green Version]
  170. Ming, L.; Wang, P.; Bank, A.; Yu, J.; Zhang, L. PUMA Dissociates Bax and Bcl-X(L) to Induce Apoptosis in Colon Cancer Cells. J. Biol. Chem. 2006, 281, 16034–16042. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  171. Yoshida, K.; Toden, S.; Ravindranathan, P.; Han, H.; Goel, A. Curcumin Sensitizes Pancreatic Cancer Cells to Gemcitabine by Attenuating PRC2 Subunit EZH2, and the LncRNA PVT1 Expression. Carcinogenesis 2017, 38, 1036–1046. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  172. Shao, J.; Shi, C.-J.; Li, Y.; Zhang, F.-W.; Pan, F.-F.; Fu, W.-M.; Zhang, J.-F. LincROR Mediates the Suppressive Effects of Curcumin on Hepatocellular Carcinoma Through Inactivating Wnt/β-Catenin Signaling. Front. Pharmacol. 2020, 11, 847. [Google Scholar] [CrossRef] [PubMed]
  173. Zhao, X.; Lu, H.; Sun, Y.; Liu, L.; Wang, H. Prognostic Value of Octamer Binding Transcription Factor 4 for Patients with Solid Tumors: A Meta-Analysis. Medicine 2020, 99, e22804. [Google Scholar] [CrossRef] [PubMed]
  174. Wang, W.-H.; Chen, J.; Zhang, B.-R.; Lu, S.-J.; Wang, F.; Peng, L.; Dai, J.-H.; Sun, Y.-Z. Curcumin Inhibits Proliferation and Enhances Apoptosis in A549 Cells by Downregulating LncRNA UCA1. Pharmazie 2018, 73, 402–407. [Google Scholar] [CrossRef] [PubMed]
  175. Wang, L.; Wu, M.; Zhou, X. Long Non-Coding RNA UCA1 Promotes Retinoblastoma Progression by Modulating the MiR-124/c-Myc Axis. Am. J. Transl. Res. 2022, 14, 1592–1605. [Google Scholar] [PubMed]
  176. Sun, K.; Jia, Z.; Duan, R.; Yan, Z.; Jin, Z.; Yan, L.; Li, Q.; Yang, J. Long Non-Coding RNA XIST Regulates MiR-106b-5p/P21 Axis to Suppress Tumor Progression in Renal Cell Carcinoma. Biochem. Biophys. Res. Commun. 2019, 510, 416–420. [Google Scholar] [CrossRef] [PubMed]
  177. Sabry, D.; Abdelaleem, O.O.; El Amin Ali, A.M.; Mohammed, R.A.; Abdel-Hameed, N.D.; Hassouna, A.; Khalifa, W.A. Anti-Proliferative and Anti-Apoptotic Potential Effects of Epigallocatechin-3-Gallate and/or Metformin on Hepatocellular Carcinoma Cells: In Vitro Study. Mol. Biol. Rep. 2019, 46, 2039–2047. [Google Scholar] [CrossRef] [PubMed]
  178. Chen, A.; Jiang, P.; Zeb, F.; Wu, X.; Xu, C.; Chen, L.; Feng, Q. EGCG Regulates CTR1 Expression through Its Pro-Oxidative Property in Non-Small-Cell Lung Cancer Cells. J. Cell. Physiol. 2020, 235, 7970–7981. [Google Scholar] [CrossRef] [PubMed]
  179. Jiang, P.; Chen, A.; Wu, X.; Zhou, M.; Ul Haq, I.; Mariyam, Z.; Feng, Q. NEAT1 Acts as an Inducer of Cancer Stem Cell-like Phenotypes in NSCLC by Inhibiting EGCG-Upregulated CTR1. J. Cell. Physiol. 2018, 233, 4852–4863. [Google Scholar] [CrossRef] [PubMed]
  180. Wang, W.; Chen, D.; Zhu, K. SOX2OT Variant 7 Contributes to the Synergistic Interaction between EGCG and Doxorubicin to Kill Osteosarcoma via Autophagy and Stemness Inhibition. J. Exp. Clin. Cancer Res. 2018, 37, 37. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  181. Hu, D.-L.; Wang, G.; Yu, J.; Zhang, L.-H.; Huang, Y.-F.; Wang, D.; Zhou, H.-H. Epigallocatechin-3-gallate Modulates Long Non-coding RNA and MRNA Expression Profiles in Lung Cancer Cells. Mol. Med. Rep. 2019, 19, 1509–1520. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  182. Chen, J.; Lin, C.; Yong, W.; Ye, Y.; Huang, Z. Calycosin and Genistein Induce Apoptosis by Inactivation of HOTAIR/p-Akt Signaling Pathway in Human Breast Cancer MCF-7 Cells. Cell. Physiol. Biochem. 2015, 35, 722–728. [Google Scholar] [CrossRef] [PubMed]
  183. Imai-Sumida, M.; Dasgupta, P.; Kulkarni, P.; Shiina, M.; Hashimoto, Y.; Shahryari, V.; Majid, S.; Tanaka, Y.; Dahiya, R.; Yamamura, S. Genistein Represses HOTAIR/Chromatin Remodeling Pathways to Suppress Kidney Cancer. Cell. Physiol. Biochem. 2020, 54, 53–70. [Google Scholar] [CrossRef] [PubMed]
  184. Zhang, X.-H.; Hu, P.; Xie, Y.-Q.; Kang, Y.-J.; Li, M. Long Noncoding RNA HOTAIR Promotes Endometrial Carcinoma Cell Proliferation by Binding to PTEN via the Activating Phosphatidylinositol 3-Kinase/Akt Signaling Pathway. Mol. Cell. Biol. 2019, 39, e00251-19. [Google Scholar] [CrossRef] [PubMed]
  185. Sadeghalvad, M.; Mansouri, K.; Mohammadi-Motlagh, H.-R.; Noorbakhsh, F.; Mostafaie, A.; Alipour, S.; Rezaei, N. Long Non-Coding RNA HOTAIR Induces the PI3K/AKT/MTOR Signaling Pathway in Breast Cancer Cells. Rev. Assoc. Med. Bras. 2022, 68, 456–462. [Google Scholar] [CrossRef] [PubMed]
  186. Chen, X.; Wu, Y.; Gu, J.; Liang, P.; Shen, M.; Xi, J.; Qin, J. Anti-Invasive Effect and Pharmacological Mechanism of Genistein against Colorectal Cancer. Biofactors 2020, 46, 620–628. [Google Scholar] [CrossRef] [PubMed]
  187. Li, Y.; Kou, J.; Wu, T.; Zheng, P.; Chao, X. Screening of Therapeutic Candidate Genes of Quercetin for Cervical Cancer and Analysis of Their Regulatory Network. OncoTargets Ther. 2021, 14, 857–866. [Google Scholar] [CrossRef] [PubMed]
  188. Lu, X.; Chen, D.; Yang, F.; Xing, N. Quercetin Inhibits Epithelial-to-Mesenchymal Transition (EMT) Process and Promotes Apoptosis in Prostate Cancer via Downregulating LncRNA MALAT1. Cancer Manag. Res. 2020, 12, 1741–1750. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  189. Esteghlal, S.; Mokhtari, M.J.; Beyzaei, Z. Quercetin Can Inhibit Angiogenesis via the Down Regulation of MALAT1 and MIAT LncRNAs in Human Umbilical Vein Endothelial Cells. Int. J. Prev. Med. 2021, 12, 59. [Google Scholar] [CrossRef] [PubMed]
  190. Sheng, B.; Zhao, L.; Zang, X.; Zhen, J.; Liu, Y.; Bian, W.; Chen, W. Quercetin Inhibits Caerulein-Induced Acute Pancreatitis through Regulating MiR-216b by Targeting MAP2K6 and NEAT1. Inflammopharmacology 2021, 29, 549–559. [Google Scholar] [CrossRef] [PubMed]
  191. Li, L.; Ye, D.; Liu, L.; Li, X.; Liu, J.; Su, S.; Lu, W.; Yu, Z. Long Noncoding RNA SNHG7 Accelerates Proliferation, Migration and Invasion of Non-Small Cell Lung Cancer Cells by Suppressing MiR-181a-5p Through AKT/MTOR Signaling Pathway. Cancer Manag. Res. 2020, 12, 8303–8312. [Google Scholar] [CrossRef]
  192. Rezaie, F.; Mokhtari, M.J.; Kalani, M. Quercetin Arrests in G2 Phase, Upregulates INXS LncRNA and Downregulates UCA1 LncRNA in MCF-7 Cells. Int. J. Mol. Cell. Med. 2021, 10, 208–216. [Google Scholar] [CrossRef]
  193. Yang, Q.; Xu, E.; Dai, J.; Liu, B.; Han, Z.; Wu, J.; Zhang, S.; Peng, B.; Zhang, Y.; Jiang, Y. A Novel Long Noncoding RNA AK001796 Acts as an Oncogene and Is Involved in Cell Growth Inhibition by Resveratrol in Lung Cancer. Toxicol. Appl. Pharmacol. 2015, 285, 79–88. [Google Scholar] [CrossRef]
  194. Kay, M.K.; Zhang, J.; Choudhury, M. Screening for Alternative Splicing of LncRNA Dleu2 in the Mouse Liver Cell Line AML-12. Biomed. Rep. 2021, 14, 50. [Google Scholar] [CrossRef]
  195. Lerner, M.; Harada, M.; Lovén, J.; Castro, J.; Davis, Z.; Oscier, D.; Henriksson, M.; Sangfelt, O.; Grandér, D.; Corcoran, M.M. DLEU2, Frequently Deleted in Malignancy, Functions as a Critical Host Gene of the Cell Cycle Inhibitory MicroRNAs MiR-15a and MiR-16-1. Exp. Cell Res. 2009, 315, 2941–2952. [Google Scholar] [CrossRef]
  196. Li, T.; Zhang, X.; Cheng, L.; Li, C.; Wu, Z.; Luo, Y.; Zhou, K.; Li, Y.; Zhao, Q.; Huang, Y. Modulation of LncRNA H19 Enhances Resveratrol-Inhibited Cancer Cell Proliferation and Migration by Regulating Endoplasmic Reticulum Stress. J. Cell. Mol. Med. 2022, 26, 2205–2217. [Google Scholar] [CrossRef]
  197. Ji, Q.; Liu, X.; Fu, X.; Zhang, L.; Sui, H.; Zhou, L.; Sun, J.; Cai, J.; Qin, J.; Ren, J.; et al. Resveratrol Inhibits Invasion and Metastasis of Colorectal Cancer Cells via MALAT1 Mediated Wnt/β-Catenin Signal Pathway. PLoS ONE 2013, 8, e78700. [Google Scholar] [CrossRef] [Green Version]
  198. Geng, W.; Guo, X.; Zhang, L.; Ma, Y.; Wang, L.; Liu, Z.; Ji, H.; Xiong, Y. Resveratrol Inhibits Proliferation, Migration and Invasion of Multiple Myeloma Cells via NEAT1-Mediated Wnt/β-Catenin Signaling Pathway. Biomed. Pharmacother. 2018, 107, 484–494. [Google Scholar] [CrossRef]
  199. Al Aameri, R.F.H.; Sheth, S.; Alanisi, E.M.A.; Borse, V.; Mukherjea, D.; Rybak, L.P.; Ramkumar, V. Tonic Suppression of PCAT29 by the IL-6 Signaling Pathway in Prostate Cancer: Reversal by Resveratrol. PLoS ONE 2017, 12, e0177198. [Google Scholar] [CrossRef] [Green Version]
  200. Lu, B.; Lv, H.; Yang, Z.; Shu, J.; Zhang, H. LncRNA PCAT29 Up-Regulates the Expression of PTEN by Down-Regulating MiR-494 in Non-Small-Cell Lung Cancer to Suppress Tumor Progression. Crit. Rev. Eukaryot. Gene Expr. 2021, 31, 9–15. [Google Scholar] [CrossRef]
  201. Liu, Q.; Sun, S.; Yu, W.; Jiang, J.; Zhuo, F.; Qiu, G.; Xu, S.; Jiang, X. Altered Expression of Long Non-Coding RNAs during Genotoxic Stress-Induced Cell Death in Human Glioma Cells. J. Neurooncol. 2015, 122, 283–292. [Google Scholar] [CrossRef]
  202. Ruan, Z.; Ma, H.; Li, J.; Liu, H.; Jia, H.; Li, F. The Long Non-Coding RNA NEAT1 Contributes to Extracellular Matrix Degradation in Degenerative Human Nucleus Pulposus Cells. Exp. Biol. Med. 2018, 243, 595–600. [Google Scholar] [CrossRef]
  203. Luan, L.; Hu, Q.; Wang, Y.; Lu, L.; Ling, J. Knockdown of LncRNA NEAT1 Expression Inhibits Cell Migration, Invasion and EMT by Regulating the MiR-24-3p/LRG1 Axis in Retinoblastoma Cells. Exp. Ther. Med. 2021, 21, 367. [Google Scholar] [CrossRef] [PubMed]
  204. Du, X.-T.; Wang, X.-Y.; Zheng, Y.-H.; Liu, D.-P. Propofol Suppresses the Growth and Invasion of Cervical Carcinoma Cells by Inhibiting MIR155HG. Aging 2021, 13, 24464–24475. [Google Scholar] [CrossRef] [PubMed]
  205. Cesmeli, S.; Goker Bagca, B.; Caglar, H.O.; Ozates, N.P.; Gunduz, C.; Biray Avci, C. Combination of Resveratrol and BIBR1532 Inhibits Proliferation of Colon Cancer Cells by Repressing Expression of LncRNAs. Med. Oncol. 2021, 39, 12. [Google Scholar] [CrossRef] [PubMed]
  206. Chen, J.; Alduais, Y.; Zhang, K.; Zhu, X.; Chen, B. CCAT1/FABP5 Promotes Tumour Progression through Mediating Fatty Acid Metabolism and Stabilizing PI3K/AKT/MTOR Signalling in Lung Adenocarcinoma. J. Cell. Mol. Med. 2021, 25, 9199–9213. [Google Scholar] [CrossRef] [PubMed]
  207. Zhu, D.; Shao, M.; Yang, J.; Fang, M.; Liu, S.; Lou, D.; Gao, R.; Liu, Y.; Li, A.; Lv, Y.; et al. Curcumin Enhances Radiosensitization of Nasopharyngeal Carcinoma via Mediating Regulation of Tumor Stem-like Cells by a CircRNA Network. J. Cancer 2020, 11, 2360–2370. [Google Scholar] [CrossRef] [PubMed]
  208. Chen, Q.; Guo, H.; Zong, Y.; Zhao, X. Curcumin Restrains Hepatocellular Carcinoma Progression Depending on the Regulation of the Circ_0078710/MiR-378b/PRIM2 Axis. J. Recept. Signal Transduct. Res. 2022, 42, 313–324. [Google Scholar] [CrossRef] [PubMed]
  209. Zhang, Z.; Li, B.; Xu, P.; Yang, B. Integrated Whole Transcriptome Profiling and Bioinformatics Analysis for Revealing Regulatory Pathways Associated With Quercetin-Induced Apoptosis in HCT-116 Cells. Front. Pharmacol. 2019, 10, 798. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  210. Yang, J.; Zhu, D.; Liu, S.; Shao, M.; Liu, Y.; Li, A.; Lv, Y.; Huang, M.; Lou, D.; Fan, Q. Curcumin Enhances Radiosensitization of Nasopharyngeal Carcinoma by Regulating CircRNA Network. Mol. Carcinog. 2020, 59, 202–214. [Google Scholar] [CrossRef] [PubMed]
  211. Xue, L.; Tao, Y.; Yuan, Y.; Qu, W.; Wang, W. Curcumin Suppresses Renal Carcinoma Tumorigenesis by Regulating Circ-FNDC3B/MiR-138-5p/IGF2 Axis. Anticancer Drugs 2021, 32, 734–744. [Google Scholar] [CrossRef] [PubMed]
  212. Wang, L.; Lee, I.-M.; Zhang, S.M.; Blumberg, J.B.; Buring, J.E.; Sesso, H.D. Dietary Intake of Selected Flavonols, Flavones, and Flavonoid-Rich Foods and Risk of Cancer in Middle-Aged and Older Women. Am. J. Clin. Nutr. 2009, 89, 905–912. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  213. D’Arcy, M.S. A Review of Biologically Active Flavonoids as Inducers of Autophagy and Apoptosis in Neoplastic Cells and as Cytoprotective Agents in Non-Neoplastic Cells. Cell Biol. Int. 2022, 46, 1179–1195. [Google Scholar] [CrossRef] [PubMed]
  214. Drețcanu, G.; Știrbu, I.; Leoplold, N.; Cruceriu, D.; Danciu, C.; Stănilă, A.; Fărcaș, A.; Borda, I.M.; Iuhas, C.; Diaconeasa, Z. Chemical Structure, Sources and Role of Bioactive Flavonoids in Cancer Prevention: A Review. Plants 2022, 11, 1117. [Google Scholar] [CrossRef] [PubMed]
  215. Nguyen, M.; Osipo, C. Targeting Breast Cancer Stem Cells Using Naturally Occurring Phytoestrogens. Int. J. Mol. Sci. 2022, 23. [Google Scholar] [CrossRef] [PubMed]
  216. Fujimura, Y.; Kumazoe, M.; Tachibana, H. 67-KDa Laminin Receptor-Mediated Cellular Sensing System of Green Tea Polyphenol EGCG and Functional Food Pairing. Molecules 2022, 27, 5130. [Google Scholar] [CrossRef] [PubMed]
Antioxidants 11 02352 g001 550
Figure 1. ROS-scavenger-triggered anticancer pathways (RSTAPs) and contribution of ncRNAs. lncRs upregulated and downregulated by polyphenols are in red and blue, respectively, on a yellow background. miRs upregulated and downregulated by polyphenols are in red and blue, respectively, on a green background.
Figure 1. ROS-scavenger-triggered anticancer pathways (RSTAPs) and contribution of ncRNAs. lncRs upregulated and downregulated by polyphenols are in red and blue, respectively, on a yellow background. miRs upregulated and downregulated by polyphenols are in red and blue, respectively, on a green background.
Antioxidants 11 02352 g001
Table
Table 1. Modulation of molecular targets of tumor-suppressor miRs upregulated by three to five CUR, EGCG, QUE, RES and GEN.
Table 1. Modulation of molecular targets of tumor-suppressor miRs upregulated by three to five CUR, EGCG, QUE, RES and GEN.
miRs miR-16 miR-22 miR-34a miR-141 miR-145 miR-146a miR-200c
Polyphenols CUR
Yang et al. [9]
EGCG Tsang et al. [10]
QUE
Sonoki et al. [11];
Zhao et al. [12]
RES
Hagiwara et al. [13];
Azimi et al. [14]		 CUR
Sun et al. [15];
Sreenivasan et al.
[16];
Sibbesen et al. [17]
EGCG
Li et al. [18]
QUE
Zhang et al. [19]		 CUR
Guo et al. [20]; Sun et al. [21];
Toden et al. [22]; Sun et al. [15]
EGCG
Chakrabarti et al. [23]; Li et al. [18];
Chakrabarti et al. [24]; Toden et al. [25]; Mostafa et al. [26]
GEN
Hsieh et al. [27]; Xia et al. [28];
Chiyomaru et al. [29]
RES
Hagiwara et al. [13]; Otsuka et al. [30];
Kumazaki et al. [31]; Yao et al. [32]		 CUR
Toden et al. [33]
EGCG
Gordon et al. [34]
GEN
Chiyomaru et al. [35]
RES
Hagiwara et al. [13]		 CUR
Mirgani et al. [36];
Liu et al. [37]
EGCG
Toden et al. [25]
GEN
Wei et al. [38]
QUE
Zhou et al. [39]
RES
Sachdeva et al. [40]		 CUR
Wu et al. [41]
GEN
Li et al. [42]
QUE
Tao et al. [43]		 CUR
Toden et al. [33];
Soubani et al. [44]
EGCG
Toden et al. [25]
RES
Hagiwara et al. [13];
Dermani et al. [45]
Targets * Bcl-2↓
CUR: Yang et al. [9];
EGCG: Tsang et al. [10]
HOXA10↓
QUE: Zhao et al. [12]		 SP1↓, ESR1↓
CUR: Sun et al. [15]
Erbb3↓
CUR: Sreenivasan et al. [16]
NCoA1↓, HDAC6↓, MYCBP↓, PTEN↓,
CUR: Sibbesen et al. [17]
Wnt1/β-catenin↓
QUE: Zhang et al. [19]		 Bcl-2↓, Bmi-1↓
CUR: Guo et al. [20]
Bcl-2↓, CDK4↓, Cyclin D1↓
CUR: Sun et al. [21]
Cyclin D↓, c-Myc↓, CDK6↓, Bcl-2↓
CUR: Toden et al. [22]
miR-92↓, miR-93↓, miR-106b↓, miR-7-1↑, miR-34a↑, miR-99a↑
EGCG: Chakrabarti et al. [23]
EMT↓, RTCB↓, ROS↑
GEN: Hsieh et al. [27]
HOTAIR↓
GEN: Chiyomaru et al. [29]
Notch-1↓
GEN: Xia et al. [28]
Sirt1↓ via E2F3
RES: Kumazaki et al. [31]
HNRNPA1↓
RES: Otsuka et al. [30]
Bcl-2↓
RES: Yao et al. [32]		 EMT↓
CUR: Toden et al. [33]
HOTAIR↓
GEN: Chiyomaru et al. [35]
Cancer stemness↓
RES: Hagiwara et al. [13]		 Oct4↓, SOX-2↓, Oct4B1↓,
CUR: Mirgani et al. [36]
Oct4↓, CD44↓, CD133↓, Cyclin D1↓, Cdk4↓
CUR: Liu et al. [37]
c-Myc↓
EGCG: Toden et al. [25]
ABCE1↓
GEN: Wei et al. [38]
Caspase-3↑
QUE: Zhou et al. [39]		 NF-κB↓
CUR: Wu et al. [41]
EGFR↓
MTA-2↓, IRAK-1↓, NF-κB↓
GEN
Li et al. [42]
Caspase 3↑, Bax↑, EGFR↓
QUE: Tao et al. [43]		 EMT↓
CUR: Toden et al. [33]
PTEN↑,
MT1-MMP↓
CUR: Soubani et al. [44]
Cancer stemness↓
EGCG: Toden et al. [25]
Cancer stemness↓
RES: Hagiwara et al. [13]
EMT↓ via vimentin, ZEB1, E-cadherin
RES: Dermani et al. [45]
* Targets upregulated and downregulated by polyphenols through upregulation of miRs are indicated by ↑ and ↓, respectively. Bcl-2; B-cell lymphoma 2, HOXA10; homeobox A10, SP1; specificity protein 1, ESR1; estrogen receptor alpha 1, Erbb3; Erb-b2 receptor tyrosine kinase 3, NCoA1; nuclear receptor coactivator 1, HDAC6; histone deacetylase 6, MYCBP; Myc binding protein, PTEN; phosphatase and tensin homolog deleted on chromosome 10, Wnt1; wingless and int-1, EMT; epithelial-mesenchymal transition, RTCB; RNA 2′,3′-cyclic phosphate and 5′-OH ligase, ROS; reactive oxygen species, HOTAIR; HOX transcript antisense RNA, Notch-1; Notch homolog protein 1, Sirt1; sirtuin 1, ABCE1; ATP-binding cassette E1, NF-κB; nuclear factor-κB, EGFR; epidermal growth factor receptor, MTA-2; metastasis-associated 2, Bax; Bcl2-associated X protein, MT1-MMP; membrane type 1-matrix metalloproteinase, Bmi-1; B-cell-specific Moloney murine leukemia virus integration site 1, CDK; cyclin-dependent kinase, E2F3; E2F transcription factor 3, HNRNPA1; heterogeneous nuclear ribonucleoprotein A1, Oct4; octamer-binding transcription factor 4, SOX-2; SRY [sex determining region Y]-box 2, ZEB1; zinc finger E-box binding homeobox 1.
Table
Table 2. Modulation of molecular targets of oncogenic miRs downregulated by three to five CUR, EGCG, QUE, RES and GEN.
Table 2. Modulation of molecular targets of oncogenic miRs downregulated by three to five CUR, EGCG, QUE, RES and GEN.
miRs miR-20a miR-21 miR-25 miR-27a miR-93 miR-106b miR-155 miR-221
Polyphenols CGA
Huang et al. [46]
CUR
Gandhy et al. [47]
EGCG
Mirzaaghaei et al. [48]
RES
Dhar et al. [49];
Dhar et al. [50]		 CGA
Wang et al. [51]
CUR
Mudduluru et al. [52];
Subramaniam et al. [53];
Zhang et al. [54];
Taverna et al. [55];
Yallapu et al. [56]
EGCG
Fix et al. [57] **;
Siddiqui et al. [58]
GEN
Zaman et al. [59]
RES
Tili et al. [60]; Sheth et al. [61]; Liu et al. [62]; Li et al. [63]; Zhou et al. [64]		 CUR
Sun et al. [15]
EGCG
Fix et al. [57] **;
Gordon et al. [34];
Zan et al. [65]
RES
Tili et al. [60]		 CUR
Toden et al. [22];
Noratto et al. [66]
EGCG
Fix et al. [57] **
GEN
Xia et al. [67];
Xu et al. [68];
Sun et al. [69]		 CGA
Huang et al. [46]
EGCG Chakrabarti et al. [23];
Chakrabarti et al. [24]
RES
Singh et al. [70]		 CGA
Huang et al. [46]
EGCG
Chakrabarti et al. [23]
RES
Dhar et al. [50];
Dhar et al. [49]		 CGA
Zeng et al. [71]
CUR
Ma et al. [72]
GEN
de la Parra et al. [73]
QUE
Boesch-Saadatmandi et al. [74]
RES
Tili et al. [75]		 CUR
Zhang et al. [76];
Allegri et al. [77]
EGCG
Allegri et al. [77]
GEN
Chen et al. [78]
Targets * p21↑
CGA: Huang et al. [46]
PTEN↑
RES: Dhar et al. [49]		 Smad7↑
CGA: Wang et al. [51]
PDCD4↑
CUR: Mudduluru et al. [52]
PTEN↑
CUR: Zhang et al. [54]
PTEN↑
CUR: Taverna et al. [55]
p21↑, p38 MAPK↑, Cyclin E2↓
GEN: Zaman et al. [59]
PDCD4↑
RES: Sheth et al. [61]
Bcl-2↓
RES: Liu et al. [62]
NF-κB↓
RES: Liu et al. [63]
AKT↓, Bcl-2↓
RES: Zhou et al. [64]		 p53↑
EGCG: Gordon et al. [34]
PARP1↑, Caspases 3↑,
Caspases 9↑
EGCG: Zan et al. [65]		 Cyclin E1↓, c-Myc↓ via FBXW7
CUR: Toden et al. [22]
ZBTB10-Sp↑
CUR: Noratto et al. [66]
Sp1↓, Sp3↓ Sp4↓, EGFR↓, hepatocyte growth factor receptor↓, survivin↓, Bcl-2↓, Cyclin D1↓, NFκB↓, ZBTB4↑
CUR: Grandhy et al. [47]
Spry2↑
GEN: Xu et al. [68]		 p21↑
CGA: Huang et al. [46]
Caspase 8↑, tBid↑, Calpain↑, Caspase 3↑
EGCG: Chakrabarti et al. [23]		 p21↑
CGA: Huang et al. [46]
PTEN↑
RES: Dhar et al. [50];
Dhar et al. [49]		 Inflammation↓ via NF-κB/NLRP3
CGA: Zeng et al. [71]
SOCS1↓, IL-6↓,
CUR: Ma et al. [72]
PTEN↑, FOXO3a↑
GEN: de la Parra et al. [73]
AP-1↓ via miR-663
RES: Tili et al. [75]		 PTEN↑, p27↑, p57↑, PUMA↑
CUR: Sarkar et al. [79]
FGF2↓, MMP2↓, VEGF↓, HGF↓,
CUR: Zhang et al. [76]
miR-21↓, miR-146b↓, miR-221↓, miR-222↓
CUR: Allegri et al. [77]
miR-221↓,
EGCG: Allegri et al. [77]
ARHI↑
GEN:Chen et al. [78]
* Targets upregulated and downregulated by polyphenols through downregulation of miRs are indicated by ↑ and ↓, respectively. ** EGCG-rich Polyphenon-E. PTEN; phosphatase and tensin homolog deleted on chromosome 10, Smad; Small mother against decapentaplegic, PDCD; programmed cell death, Bcl-2; B-cell lymphoma 2, NF-κB; nuclear factor-κB, AKT; AKT serine/threonine kinase 1, PARP; poly(ADP-ribose) polymerase 1, FBXW7; F-Box And WD Repeat Domain Containing 7, ZBTB10; Zinc finger and BTB domain containing 10, Sp1; specificity protein 1, EGFR; epidermal growth factor receptor, Spry2; Sprouty RTK signaling antagonist 2, tBid; truncated BH3 interacting domain death agonist, NLRP3; NLR family, pyrin domain containing 3, SOCS1; suppressor of cytokine signal 1, IL-6; interleukin-6, FOXO3a; forkhead Box O3, AP-1; Activator protein 1, PUMA; p53-upregulated modulator of apoptosis, ARHI; age-related hearing impairment, FGF2; fibroblast growth factor 2, MMP; matrix metalloproteinase, VEGF; vascular endothelial growth factor, HGF; hepatocyte growth factor.
Table
Table 3. miRs upregulated by one of five dietary polyphenols and their proposed targets *.
Table 3. miRs upregulated by one of five dietary polyphenols and their proposed targets *.
CUR EGCG GEN QUE RES
miR-7
SET8↓, Bcl-2↓, p53↑ [80];
Skp2↓, p57↑, p21↑ [81]
miR-9
AKT↓, FOXO1↓ [82];
GSK-3β↑, β-catenin↑, Cyclin D1↓ [83]
miR-15a
Bcl-2↓ [9]; WT1↓ [84]
miR-16-1
WT1↓ [84]
miR-28-5p
BECN1↓ [85]
miR-29a
DNMT1↓, 3A↓, 3B↓ [86]
miR-30c-5p
MTA1↓ [87]
miR-33b
HMGA2↓ [88]; XIAP↓ [89]
miR-98
LIN28A↓, MMP2↓, MMP9↓ [90]
miR-99a
JAK1↓, STAT1↓, STAT3↓ [91]
miR-101
EZH2↓, EpCAM↓ [92];
Notch1↓ [93]; EZH2↓ [94]
miR-124
Midkine↓ [95]		 miR-125a
ERRα↓ [96]
miR-138
Smad4↓, NF-kB↓, Cyclin D3↓ [97]
miR-143
NF-kB↓ [98]; PGK1↓ [99];
Autophagy via ATG2B↓ [100]
miR-181b
CXCL1↓ [101]
miR-185
DNMT1↓, 3A↓, 3B↓ [86]
miR-192-5p
XIAP↓ [102]; PI3K↓, AKT↓ [103];
Wnt/β-catenin↓ [104]
miR-196b **
BCR-ABL↓ [55]
miR-206
mTOR↓, AKT↓ [105]
miR-215
XIAP↓ [102]
miR-340
XIAP↓ [106]
miR-384
circ-PRKCA↓ [107]
miR-491
PEG10↓ [108]
miR-593
MDR1↓ [109]		 miR-15b
STIM2↓, Orai1↓ [110]
miR-29b
KDM2A↓ [111]
miR-485-5p
RXRα↓ [112]
let-7b
HMGA2↓ [113]		 miR-574-3p
RAC1↓, EGFR↓, EP300↓ [114]
miR-1469
Mcl1↓ [115]
let-7d
THBS1↓ [116]		 miR-1-3p
TAGLN2↓ [117]
miR-16-5p
WEE1↓ [118]
miR-22
Wnt1↓ [19]
miR-34a-5p
SNHG7↓ [119]
miR-142-3p
HSP70 ↓ [120]
miR-197
IGFBP5↓ [121]
miR-200b-3p
Notch1↓ [122]
miR-217
KRAS↓ [123]
miR-503-5p
Cyclin D1↓ [124]
miR-1254
CD36↓ [125]
miR-1275
IGF2BP1↓, IGF2BP3↓ [126]
let7-a
KRAS↓ [127]
let-7c
Numbl/Notch1↑ [128]		 miR-424-3p
Galectin-3↓ [129]
* Upregulation (↑) and downregulation (↓) of miR targets by polyphenols are indicated. ** Downregulation by RES is reported [130]. SET8; SET domain-containing lysine methyltransferase 8, Bcl-2; B-cell lymphoma 2, Skp2; S-phase kinase-associated protein 2, AKT; AKT serine/threonine kinase 1, FOXO1; forkhead Box O1, GSK-3β; glycogen synthase kinase-3 beta, WT1; Wilms’ tumor-1, BECN1; beclin 1, DNMT; DNA methyltransferase, MTA1; metastasis-associated 1, HMGA2; high mobility group A2, XIAP; X-linked inhibitor of apoptosis, LIN28A; Lin-28 homolog A, MMP; matrix metalloproteinase, JAK1; Janus kinase 1; STAT; signal transducer and activator of transcription, EZH2; enhancer of zeste homolog 2, EpCAM; epithelial cell adhesion molecule, Notch1; neurogenic locus notch homolog protein 1, ERRα; estrogen-related receptor alpha, PGK1; phosphoglycerate kinase 1, ATG2B; autophagy-related 2B, CXCL1; chemokine (C-X-C motif) ligand 1, PI3K; phosphoinositide-3 kinase, Wnt; wingless and int-1, BCR-ABL; BCR-ABL fusion gene, mTOR; mammalian target of rapamycin, circ-PRKCA; circ_0007580, PEG10; paternally expressed gene 10, MDR1; multidrug resistance mutation1, STIM2; Stromal interaction molecule 2, Orai1; ORAI calcium release-activated calcium modulator 1, KDM2A; lysine demethylase 2A, RXRα; retinoid X receptor alpha, RAC1; ras-related C3 botulinum toxin substrate 1, EGFR; epidermal growth factor receptor, EP300; E1A-associated protein P300, THBS1; thrombospondin 1, TAGLN2; transgelin 2, WEE1; WEE1 G2 checkpoint kinase, SNHG7, small nucleolar RNA host gene 7, HSP; heat shock protein, IGFBP; insulin-like growth factor binding protein, KRAS; KRAS proto-oncogene, GTPase, Numbl; NUMB like endocytic adaptor protein, Mcl1; myeloid cell leukemia 1, IGF2BP; insulin-like growth factor 2 mRNA binding protein.
Table
Table 4. miRs downregulated by one of six dietary polyphenols and their targets *.
Table 4. miRs downregulated by one of six dietary polyphenols and their targets *.
CGA CUR EGCG GEN QUE RES
miR-17
p21↑, G0/G1 arrest↑ [46]		 miR-19a,b
PTEN↑ [131]
miR-125a-5p
TP53↑ [132]
miR-130a
Nkd2↑ [133]
miR-7641
p16↑ [134]		 miR-98-5p
CTR1↑ [135]		 miR-23b-3p
PTEN↑ [136]
miR-151a-5p
CASZ1↑, IL1RAPL1↑, SOX17↑, N4BP1↑, ARHGDIA↑ [137]
miR-155
PTEN↑ [73]
miR-221
miR-222
ARHI↑ [78]
miR-223
Fbw7↑ [138]
miR-223
E-cadherin↑ [139]
miR-873-5p
FOXM1↓ [140]
miR-1260b
sFRP1↑, Smad4↑, Dkk2↑ [141,142]		 miR-30d-5p
Notch↓ Wnt↓ [143]		 miR-196b **
miR-1290
IGFBP3↑ [130]
* Upregulation (↑) and downregulation (↓) of miR targets by polyphenols are indicated. ** Upregulation by CUR is also reported [55]. PTEN; phosphatase and tensin homolog deleted on chromosome 10, Nkd2; naked cuticle homolog 2, CTR1; copper transporter 1, CASZ1; castor zinc finger 1, IL1RAPL1; interleukin 1 receptor accessory protein like 1, SOX17, SRY-box transcription factor 17, N4BP1; NEDD4-binding protein 1, ARHGDIA, rho-GDP dissociation inhibitor-alpha, ARHI; age-related hearing impairment, Fbw7; F-Box and WD repeat domain-containing 7, FOXM1; forkhead box M1, sFRP1; secreted frizzled-related protein 1, Smad; small mother against decapentaplegic, Dkk2; Dickkopf-related protein 2, Wnt; wingless and int-1, IGFBP; insulin-like growth factor binding protein.
Table
Table 5. Modulation of lncRs by six dietary polyphenols and targets affected by lncRs.
Table 5. Modulation of lncRs by six dietary polyphenols and targets affected by lncRs.
lncR Upregulation Downregulation Effects of Polyphenols on Proposed Targets of lncRs (↑, Upregulation; ↓, Downregulation)
AF085935 EGCG [177] Not specified
AK001796 RES [193] Cell-cycle arrest↑ [193]
AK294004 CUR [156] Cyclin D1↓ [156]
CCAT1 RES [205] PI3K/AKT/mTOR↓ [206]
DLEU2 RES [194] Cyclins E1 and D1↓ [195]
GAS5 CGA [152]
CUR [157]		 miR-23a↓ by sponging [152]
H19 RES (at 50 μM) [196] CUR [159,160,161]
RES (at 200 μM) [162]		 Cell cycle arrest at S-phase↑ [196], p53↑ [160]
EMT↓, invasion and migration via upregulating Snail [161]
HOTAIR GEN [29,35,182,183]
RES, [205]		 PI3K/AKT/mTOR signaling pathway↓ [184,185]
KCNQ1OT1 CUR [162] Bcl-2↓ via miR-497 [162]
LINC00511 EGCG [111] miR-29b↑ [111]
LINC00691 CUR [163] AKT↓ [163]
LINC-PINT CUR [164] Cell cycle arrest at G2/M↑ [164]
MALAT1 RES [196] QUE [187,188,189]
RES [197]		 Wnt/β-catenin signaling↓ [197]
MEG3 CUR [165,167] PTEN↑ [167]
NEAT1 EGCG [135,178] EGCG [179]
QUE [190]
RES [198]		 ERK1/2↓ [178]
miR-98-5p↑ [135] by sponging
Cancer cell stemness↓ [179]
NRB2 CUR [168] AMPK/mTOR pathway↑ [168]
PANDAR CUR [169] Bax↑ via upregulation of PUMA [169,170]
PCAT29 RES [199] PTEN↑ via downregulation of miR-494 [200]
ROR CUR [37,172] Wnt/β-catenin↓ [172]
Oct4↓ via sponging miR-145 [37]
SNHG7 QUE [119] AKT/mTOR↓ [191]
SOX2OT variant 7 EGCG [180] Cancer cell stemness↓ in combination with doxorubicin [180]
TTTY18 GEN [186] AKT↓ [186]
TUG1 CGA [153] Not specified
UCA1 CUR [174]
QUE [192]		 Wnt/mTOR↓ [174]
c-Myc↓ by sponging miR-124 [175]
XIST CUR [176] p21↑ [176]
PI3K; phosphatidylinositol 3-kinase, AKT; AKT serine/threonine kinase 1, mTOR; mammalian target of rapamycin, Bcl-2; B-cell lymphoma 2, PTEN; phosphatase and tensin homologs deleted on chromosome 10, ERK; extracellular signal-regulated kinase, AMPK; AMP-activated protein kinase, Bax; Bcl2-associated X protein, oct4; Octamer-binding transcription factor.
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Hayakawa, S.; Ohishi, T.; Oishi, Y.; Isemura, M.; Miyoshi, N. Contribution of Non-Coding RNAs to Anticancer Effects of Dietary Polyphenols: Chlorogenic Acid, Curcumin, Epigallocatechin-3-Gallate, Genistein, Quercetin and Resveratrol. Antioxidants 2022, 11, 2352. https://doi.org/10.3390/antiox11122352

AMA Style

Hayakawa S, Ohishi T, Oishi Y, Isemura M, Miyoshi N. Contribution of Non-Coding RNAs to Anticancer Effects of Dietary Polyphenols: Chlorogenic Acid, Curcumin, Epigallocatechin-3-Gallate, Genistein, Quercetin and Resveratrol. Antioxidants. 2022; 11(12):2352. https://doi.org/10.3390/antiox11122352

Chicago/Turabian Style

Hayakawa, Sumio, Tomokazu Ohishi, Yumiko Oishi, Mamoru Isemura, and Noriyuki Miyoshi. 2022. "Contribution of Non-Coding RNAs to Anticancer Effects of Dietary Polyphenols: Chlorogenic Acid, Curcumin, Epigallocatechin-3-Gallate, Genistein, Quercetin and Resveratrol" Antioxidants 11, no. 12: 2352. https://doi.org/10.3390/antiox11122352

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