Abstract
Anoikis is defined as apoptosis that is induced by inadequate or inappropriate cell-matrix interactions. It is involved in a wide diversity of tissue-homeostatic, developmental and oncogenic processes. The central problem of anoikis is to understand how integrin-mediated cell adhesion signals control the apoptotic machinery. In particular, the initiation of the caspase cascade in anoikis remains to be explained.
MeSH terms
- Adaptor Proteins, Signal Transducing*
- Anoikis*
- Carrier Proteins / metabolism
- Cytoskeleton / physiology
- Fas-Associated Death Domain Protein
- Growth Substances / physiology
- Humans
- Integrins / physiology*
- MAP Kinase Signaling System
- Models, Biological
- Neoplasms / pathology
- Phosphatidylinositol 3-Kinases / physiology
- Protein Serine-Threonine Kinases*
- Proto-Oncogene Proteins / physiology
- Proto-Oncogene Proteins c-akt
- Signal Transduction
Substances
- Adaptor Proteins, Signal Transducing
- Carrier Proteins
- FADD protein, human
- Fas-Associated Death Domain Protein
- Growth Substances
- Integrins
- Proto-Oncogene Proteins
- Protein Serine-Threonine Kinases
- Proto-Oncogene Proteins c-akt