Lung cancer is one of the most common malignant tumors in the world, but its pathogenesis has still been remaining confusing. As an important protein in several signaling pathways, Akt has been identified to play a major role in the growth, proliferation, apoptosis and invasion of tumor cells. This paper is to review the effects of Akt, together with PDK1, Raf-1 and p70S6K, which are upstream and downstream regulatory molecules of Akt, and provide a new basis for the pathogenesis of non-small cell lung cancer.
肺癌是目前世界上最常见的恶性肿瘤之一，但其发病机制尚不完全清楚。Akt是一种重要的信号通路关键蛋白，广泛参与肿瘤细胞的生长、增殖、凋亡及侵袭等过程。本文就Akt及其重要的上下游调节分子之——PDK1、Raf-1和p70S6K在非小细胞肺癌中的作用研究现状做一综述，以期为阐明非小细胞肺癌的发病机制提供新的依据。