Abstract
The substrates of mammalian ULK1/2 and its yeast homologue Atg1 in autophagy have remained elusive. The class III phosphatidylinositol 3-kinase component Beclin-1 has now been identified as a physiological substrate of the ULK kinases in autophagy following amino acid starvation, therefore suggesting a critical molecular link between the upstream kinases and the autophagy core machinery.
MeSH terms
- Animals
- Apoptosis Regulatory Proteins / metabolism*
- Autophagy*
- Autophagy-Related Protein-1 Homolog
- Beclin-1
- Class III Phosphatidylinositol 3-Kinases / metabolism*
- Embryo, Mammalian / metabolism*
- Fibroblasts / metabolism*
- Humans
- Protein Serine-Threonine Kinases / physiology*
Substances
- Apoptosis Regulatory Proteins
- Beclin-1
- Becn1 protein, mouse
- Class III Phosphatidylinositol 3-Kinases
- Autophagy-Related Protein-1 Homolog
- Protein Serine-Threonine Kinases
- Ulk1 protein, mouse