Prospect
Apoptosis and lung cancer: A review
Narayan Shivapurkar,
Jyotsna Reddy,
Preet M. Chaudhary,
Adi F. Gazdar,
Narayan Shivapurkar
Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8593
Departments of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8593
Search for more papers by this authorJyotsna Reddy
Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8593
Search for more papers by this authorPreet M. Chaudhary
Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8593
Search for more papers by this authorCorresponding Author
Adi F. Gazdar
Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8593
Departments of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8593
Hamon Center for Therapeutic Oncology Research, NB8. 106, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390-8593.Search for more papers by this author
Narayan Shivapurkar,
Jyotsna Reddy,
Preet M. Chaudhary,
Adi F. Gazdar,
Narayan Shivapurkar
Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8593
Departments of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8593
Search for more papers by this authorJyotsna Reddy
Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8593
Search for more papers by this authorPreet M. Chaudhary
Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8593
Search for more papers by this authorCorresponding Author
Adi F. Gazdar
Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8593
Departments of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8593
Hamon Center for Therapeutic Oncology Research, NB8. 106, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390-8593.Search for more papers by this authorAbstract
It is important to understand the molecular events that contribute to drug-induced apoptosis, and how tumors evade apoptotic death. Defects in apoptosis are implicated in both tumorigenesis and drug resistance, and these defects are cause of chemotherapy failures. These studies should explain the relationship between cancer genetics and treatment sensitivity, and should enable a more rational approach to anticancer drug design and therapy. Lung cancer is a major cause of cancer deaths throughout the world. Small cell lung carcinoma (SCLC) and non-small cell lung carcinoma (NSCLC) represent the two major categories of lung cancer that differ in their sensitivity to undergo apoptosis. The role of apoptosis regulation in lung cancer with major focus on the differential sensitivities of the major subtypes is reviewed. J. Cell. Biochem. 88: 885–898, 2003. © 2003 Wiley-Liss, Inc.
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