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Role of Herbal Medicine in Boosting Immune System

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Role of Herbal Medicines

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Abstract

Herbal medicines are the medicines obtained from plant sources. This is an alternate type of treatment based on traditional knowledge and scientific evidences in many cases. The utility of plants as whole or their parts like fruits, flowers, leaves, stem, and roots have been established for the treatment of many diseases. The active ingredients present in the plants either alone or in combination have improved the immune system if taken with proper care. Many studies have shown that these are better in comparison to conventional modern treatment with respect to less or no side effects. This chapter focused on the use of herbal medicines in boosting the immune system. This chapter covers why people prefer herbal medicines, role of some herbal plants in enhancing the immune system, and role of some individual natural products in boosting the immune system.

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References

  1. Tan BK, Vanitha J. Immunomodulatory and antimicrobial effects of some traditional Chinese medicinal herbs: a review. Curr Med Chem. 2004;11(11):1423–30.

    Article  PubMed  Google Scholar 

  2. Sharma P, Kumar P, Sharma R, Gupta G, Chaudhary A. Immunomodulators: role of medicinal plants in immune system. Natl J Physiol Pharm Pharmacol. 2017;7(6):552.

    Article  Google Scholar 

  3. Debnath S, Chakravorty R, Devi D. A review on role of medicinal plants in immune system. Asian J Pharm Technol. 2020;10(4):273–7.

    Article  Google Scholar 

  4. Gasmi A, Shanaida M, Oleshchuk O, Semenova Y, Mujawdiya PK, Ivankiv Y, Pokryshko O, Noor S, et al. Natural ingredients to improve immunity. Pharmaceuticals. 2023;16:528.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Maqbool M, Dar MA, Gani I, Mir SA, Khan M. Herbal medicines as an alternative source of therapy: a review. World J Pharm Pharm Sci. 2019;3:374–80.

    Google Scholar 

  6. Butler MS. The role of natural product chemistry in drug discovery. J Nat Prod. 2004;67(12):2141–53.

    Article  PubMed  Google Scholar 

  7. Kew J, Morris C, Aihie A, Fysh R, Jones S, Brooks D. Arsenic and mercury intoxication due to Indian ethnic remedies. Br Med J. 1993;306(6876):506.

    Article  Google Scholar 

  8. Pal SK, Shukla Y. Herbal medicine: current status and the future. Asian Pac J Cancer Prev. 2003;4(4):281–8.

    PubMed  Google Scholar 

  9. Das S, Bordoloi R, Newar N. A review on immune modulatory effect of some traditional medicinal herbs. J Pharm Chem Biol Sci. 2014;2(1):33–42.

    Google Scholar 

  10. Frazzoli C, Grasso G, Husaini DC, Ajibo DN, Orish FC, Orisakwe OE. Immune system and epidemics: the role of African indigenous bioactive substances. Nutrients. 2023;15(2):273.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Panyod S, Ho CT, Sheen LY. Dietary therapy and herbal medicine for COVID-19 prevention: A review and perspective. J Tradit Complement Med. 2020;10(4):420–7.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Winslow LC, Kroll DJ. Herbs as medicines. Arch Intern Med. 1998;158(20):2192–9.

    Article  Google Scholar 

  13. Miller LG. Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions. Arch Intern Med. 1998;158(20):2200–11.

    Article  PubMed  Google Scholar 

  14. Tsai CW, Chen HW, Sheen LY, Lii CK. Garlic: health benefits and actions. Biomedicine. 2012;2(1):17–29.

    Article  Google Scholar 

  15. Gebreyohannes G, Gebreyohannes M. Medicinal values of garlic: A review. Int J Med Med Sci. 2013;5(9):401–8.

    Google Scholar 

  16. Zheng D, Liwinski T, Elinav E. Interaction between microbiota and immunity in health and disease. Cell Res. 2020;30:492–506.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Bhowmik D, Chiranjib YJ, Tripathi KK, Kumar KS. Herbal remedies of Azadirachta indica and its medicinal application. J Chem Pharm Res. 2010;2(1):62–72.

    Google Scholar 

  18. Sahoo JP, Behera L, Praveena J, Sawant S, Mishra A, Sharma SS, Ghosh L, Mishra AP, Sahoo AR, Pradhan P, Sahu S. The golden spice turmeric (Curcuma longa) and its feasible benefits in prospering human health—a review. Am J Plant Sci. 2021;12(3):455–75.

    Article  Google Scholar 

  19. Sahoo JP, Mohapatra U, Mishra AP, Samal K. Turmeric (Haldi)-A strapping strategy for enhancing the immune system to reduce the effect of SARS-CoV-2. Food Sci Rep. 2020;1(8):10.

    Google Scholar 

  20. Chopra RN, Nayar SL. Glossary of Indian medicinal plants. Council of Scientific and Industrial Research; 1956.

    Google Scholar 

  21. Rabe T, Van Staden J. Antibacterial activity of South African plants used for medicinal purposes. J Ethnopharmacol. 1997;56(1):81–7.

    Article  PubMed  Google Scholar 

  22. Verma S, Singh SP. Current and future status of herbal medicines. Vet World. 2008;1(11):347.

    Article  Google Scholar 

  23. Lele RD. Ayurveda (ancient Indian system of medicine) and modern molecular medicine. J Assoc Physicians India. 1999;47(6):625–8.

    PubMed  Google Scholar 

  24. Valiathan MS. Healing plants. Curr Sci. 1998;75(11):1122–7.

    Google Scholar 

  25. Bhatt AD, Bhatt NS. Indigenous drugs and liver disease. Indian J Gastroenterol. 1996;15(2):63–7.

    PubMed  Google Scholar 

  26. Patil US, Jaydeokar AV, Bandawane DD. Immunomodulators: A pharmacological review. Int J Pharm Pharm Sci. 2012;4(1):30–6.

    Google Scholar 

  27. Falzon CC, Balabanova A. Phytotherapy: an introduction to herbal medicine. Prim Care. 2017;44(2):217–27.

    Article  PubMed  Google Scholar 

  28. Rajeswari R, Umadevi M, Rahale CS, Pushpa R, Selvavenkadesh S, Kumar KS, Bhowmik D. Aloe vera: the miracle plant its medicinal and traditional uses in India. J Pharmacogn Phytochem. 2012;1(4):118–24.

    Google Scholar 

  29. Hamman JH. Composition and applications of aloe vera leaf gel. Molecules. 2008;13(8):1599–616.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Qadir MI. Composition and applications of aloe vera leaf gel. Int J Nat Sci. 2009;2:21–6.

    Google Scholar 

  31. Singh UP, Prithiviraj B, Sarma BK, Singh M, Ray AB. Role of garlic (Allium sativum L.) in human and plant diseases. Indian J Exp Biol. 2001;39(4):310–22.

    PubMed  Google Scholar 

  32. Butt MS, Sultan MT, Butt MS, Iqbal J. Garlic: nature’s protection against physiological threats. Crit Rev Food Sci Nutr. 2009;49(6):538–51.

    Article  PubMed  Google Scholar 

  33. Sun Y, Xun K, Wang Y, Chen X. A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs. Anti-Cancer Drugs. 2009;20(9):757–69.

    Article  PubMed  Google Scholar 

  34. Wang S, Li Z, Ma Y, Liu Y, Lin CC, Li S, Zhan J, Ho CT. Immunomodulatory effects of green tea polyphenols. Molecules. 2021;26(12):3755.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Steinmann J, Buer J, Pietschmann T, Steinmann E. Anti-infective properties of epigallocatechin-3-gallate (EGCG), a component of green tea. Br J Pharmacol. 2013;168(5):1059–73.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Ikram A, Khalid W, Saeed F, Arshad MS, Afzaal M, Arshad MU. Senna: as immunity boosting herb against COVID-19 and several other diseases. J Herb Med. 2023;10:100626.

    Article  Google Scholar 

  37. Gupta S, Bansal RN, Sodhi SP, Brar GK, Molhotra M. Ashwagandha (Withania somnifera)–a herb with versatile medicinal properties empowering human physical and mental health. J Pre-Clin Clin Res. 2021;15(3):129–33.

    Article  Google Scholar 

  38. Gayen KC, Jana P, Giri A. Use of ashwagandha to boost immunity to combat COVID-19. In: Immunity boosting functional foods to combat COVID-19, vol. 14. CRC Press; 2021. p. 47–52.

    Google Scholar 

  39. Palai SS, Giri A. Tulsi-A potential immune boosting functional food ingredient to combat COVID-19. In: Immunity boosting functional foods to combat COVID-19, vol. 14. CRC Press; 2021. p. 27–36.

    Google Scholar 

  40. Srivastava AK, Singh VK. Tulsi (Ocimum sanctum): A potent adaptogen. Clin Res Notes. 2021;2(2):01–5.

    Article  Google Scholar 

  41. Priya FF, Islam MS. Phyllanthus emblica Linn. (Amla)—a natural gift to humans: an overview. J Dis Med Plants. 2019;5:1–9.

    Google Scholar 

  42. Abinaya S, Gayatri Devi R, Lakshmanan G. Knowledge and awareness about ginger and turmeric as a herbal cure for COVID-19. Int J Pharm Res. 2020:768–77.

    Google Scholar 

  43. Singh S, Paul V, Singh R. Cinnamon powder and its importance for immunity and human health. BMC Complement Altern Med. 13:275Y284.

    Google Scholar 

  44. Dutta A, Chakraborty A. Cinnamon in anticancer armamentarium: a molecular approach. J Toxicol. 2018;29:2018.

    Google Scholar 

  45. Singh NA, Kumar P, Jyoti KN. Spices and herbs: potential antiviral preventives and immunity boosters during COVID-19. Phytother Res. 2021;35(5):2745–57.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Singh S, Parmar N, Patel B. A review on Shalparni (Desmodium gangeticum DC.) and Desmodium species (Desmodium triflorum DC. & Desmodium laxiflorum DC.)–ethnomedicinal perspectives. J Med Plants. 2015;3(4):38–43.

    Google Scholar 

  47. Sabu MC, Kuttan R. Antidiabetic and antioxidant activity of Terminalia bellirica. Roxb. Indian J Exp Biol. 2009;47(4):270–5.

    PubMed  Google Scholar 

  48. Saha S, Ghosh S. Tinospora cordifolia: one plant, many roles. Anc Sci Life. 2012;31(4):151.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Bhakta S, Das SK. The medicinal values of Abrus precatorius: a review study. J Adv Biotechnol Exp Ther. 2020;3(2):84–91.

    Article  Google Scholar 

  50. Pattanayak S. Use of succulent bio-medicines to control COVID-19. Sikdar Bagan Street: Calcutta Block and Print; 2020.

    Google Scholar 

  51. Allam G. Immunomodulatory effects of curcumin treatment on murine schistosomiasis mansoni. Immunobiology. 2009;214(8):712–27.

    Article  PubMed  Google Scholar 

  52. Vetvicka V, Vetvickova J. Immune enhancing effects of WB365, a novel combination of Ashwagandha (Withania somnifera) and Maitake (Grifola frondosa) extracts. N Am J Med Sci. 2011;3(7):320.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Yamada K, Hung P, Park TK, Park PJ, Lim BO. A comparison of the immunostimulatory effects of the medicinal herbs Echinacea, Ashwagandha and Brahmi. J Ethnopharmacol. 2011;137(1):231–5.

    Article  PubMed  Google Scholar 

  54. Padhy M. A review on medicinal plants Withania somnifera and Nyctanthes arbortristis: boosting of immune system during SARS-CoV-2. Lett Appl NanoBioScience. 2020;9:1538–46.

    Article  Google Scholar 

  55. Singh P, Chakraborty P, He DH, Mergia A. Extract prepared from the leaves of Ocimum basilicum inhibits the entry of Zika virus. Acta Virol. 2019;1:63.

    Google Scholar 

  56. McKay DL, Blumberg JB. A review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.). Phytother Res. 2006;20(7):519–30.

    Article  PubMed  Google Scholar 

  57. Marissal-Arvy N, Batandier C, Dallennes J, Canini F, Poulet L, Couturier K, Hininger-Favier I, Moisan MP, Roussel AM, Mormede P. Effect of a high-fat–high-fructose diet, stress, and cinnamon on central expression of genes related to immune system, hypothalamic–pituitary–adrenocortical axis function and cerebral plasticity in rats. Br J Nutr. 2014;111(7):1190–201.

    Article  PubMed  Google Scholar 

  58. Randhawa MA, Alghamdi MS. Anticancer activity of Nigella sativa (black seed)—a review. Am J Chin Med. 2011;39(06):1075–91.

    Article  PubMed  Google Scholar 

  59. Sun T, Xu Z, Wu CT, Janes M, Prinyawiwatkul W, No HK. Antioxidant activities of different colored sweet bell peppers (Capsicum annuum L.). J Food Sci. 2007;72(2):S98–102.

    Article  PubMed  Google Scholar 

  60. Brush J, Mendenhall E, Guggenheim A, Chan T, Connelly E, Soumyanath A, Buresh R, Barrett R, Zwickey H. The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD69 expression and immune cell activation in humans. Phytother Res. 2006;20(8):687–95.

    Article  PubMed  Google Scholar 

  61. Kocaadam B, Şanlier N. Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Crit Rev Food Sci Nutr. 2017;57(13):2889–95.

    Article  PubMed  Google Scholar 

  62. Kunnumakkara AB, Bordoloi D, Padmavathi G, Monisha J, Roy NK, Prasad S, Aggarwal BB. Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases. Br J Pharmacol. 2017;174(11):1325–48.

    Article  PubMed  Google Scholar 

  63. Kant V, Gopal A, Pathak NN, Kumar P, Tandan SK, Kumar D. Antioxidant and anti-inflammatory potential of curcumin accelerated the cutaneous wound healing in streptozotocin-induced diabetic rats. Int Immunopharmacol. 2014;20(2):322–30.

    Article  PubMed  Google Scholar 

  64. Ganjali S, Sahebkar A, Mahdipour E, Jamialahmadi K, Torabi S, Akhlaghi S, Ferns G, Parizadeh SM, Ghayour-Mobarhan M. Investigation of the effects of curcumin on serum cytokines in obese individuals: a randomized controlled trial. Sci World J. 2014;2014

    Google Scholar 

  65. Sahebkar A. Dual effect of curcumin in preventing atherosclerosis: the potential role of pro-oxidant–antioxidant mechanisms. Nat Prod Res. 2015;29(6):491–2.

    Article  PubMed  Google Scholar 

  66. Panahi Y, Sahebkar A, Parvin S, Saadat A. A randomized controlled trial on the anti-inflammatory effects of curcumin in patients with chronic sulphur mustard-induced cutaneous complications. Ann Clin Biochem. 2012;49(6):580–8.

    Article  PubMed  Google Scholar 

  67. Momtazi AA, Shahabipour F, Khatibi S, Johnston TP, Pirro M, Sahebkar A. Curcumin as a microRNA regulator in cancer: a review. Rev Physiol Biochem Pharmacol. 2016;171:1–38.

    Article  PubMed  Google Scholar 

  68. Momtazi AA, Derosa G, Maffioli P, Banach M, Sahebkar A. Role of microRNAs in the therapeutic effects of curcumin in non-cancer diseases. Mol Diagn Ther. 2016;20:335–45.

    Article  PubMed  Google Scholar 

  69. Esmaily H, Sahebkar A, Iranshahi M, Ganjali S, Mohammadi A, Ferns G, Ghayour-Mobarhan M. An investigation of the effects of curcumin on anxiety and depression in obese individuals: A randomized controlled trial. Chin J Integr Med. 2015;21:332–8.

    Article  PubMed  Google Scholar 

  70. Rathaur P, Raja W, Ramteke PW, John SA. Turmeric: the golden spice of life. Int J Pharm Sci Res. 2012;1;3(7):1987.

    Google Scholar 

  71. Gautam SC, Gao X, Dulchavsky S. Immunomodulation by curcumin. In: The molecular targets and therapeutic uses of curcumin in health and disease, vol. 1. Boston, MA: Springer; 2007. p. 321–41.

    Google Scholar 

  72. Kurup VP, Barrios CS. Immunomodulatory effects of curcumin in allergy. Mol Nutr Food Res. 2008;52(9):1031–9.

    Article  PubMed  Google Scholar 

  73. Irfandi R, Ilham M, Erwing R, Arafah M, Rompegading AB, Putri SE, Sartika SD, Fauziah S, Agustina AS, Akbar H. Review on curcumin compounds in turmeric plants for the treatment of COVID-19. Int J Des Nat Ecodyn. 2022;17:957–65.

    Article  Google Scholar 

  74. Gibbons A. Archaeology. Ancient figs push back origin of plant cultivation. Science. 2006;312(5778):1292.

    Article  PubMed  Google Scholar 

  75. Yang XM, Yu W, Ou ZP, Ma HL, Liu WM, Ji XL. Antioxidant and immunity activity of water extract and crude polysaccharide from Ficus carica L. fruit. Plant Foods Hum Nutr. 2009;64(2):167–73.

    Article  PubMed  Google Scholar 

  76. Chen R, Li H, Li S, Jin C, Lu J. Extraction optimization, preliminary characterization and immunological activity of polysaccharides from figs. Int J Biol Macromol. 2015;72:185–94.

    Article  PubMed  Google Scholar 

  77. Du J, Li J, Zhu J, Huang C, Bi S, Song L, Hu X, Yu R. Structural characterization, and immunomodulatory activity of a novel polysaccharide from Ficus carica. Food Funct. 2018;9(7):3930–43.

    Article  PubMed  Google Scholar 

  78. Zou Q, Zhang X, Liu X, Li Y, Tan Q, Dan Q, Yuan T, Liu X, Liu RH, Liu Z. Ficus carica polysaccharide attenuates DSS induced ulcerative colitis in C57BL/6 mice. Food Funct. 2020;11(7):6666–79.

    Article  PubMed  Google Scholar 

  79. Zhang J, Wu C, Gao L, Du G, Qin X. Astragaloside IV derived from Astragalus membranaceus: A research review on the pharmacological effects. Adv Pharmacol. 2020;87:89–112.

    Article  PubMed  Google Scholar 

  80. Yang ZG, Sun HX, Fang WH. Haemolytic activities and adjuvant effect of Astragalus membranaceus saponins (AMS) on the immune responses to ovalbumin in mice. Vaccine. 2005;23(44):5196–203.

    Article  PubMed  Google Scholar 

  81. De-Hong YU, Yong-Ming BA, Li-Jia AN, Ming YA. Protection of PC12 cells against superoxide-induced damage by isoflavonoids from Astragalus mongholicus. Biomed Environ Sci. 2009;22(1):50–4.

    Article  Google Scholar 

  82. Qin Q, Niu J, Wang Z, Xu W, Qiao Z, Gu Y. Astragalus membranaceus inhibits inflammation via phospho-P38 mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-κB pathways in advanced glycation end product-stimulated macrophages. Int J Mol Sci. 2012;13(7):8379–87.

    Article  PubMed  PubMed Central  Google Scholar 

  83. Shen HH, Wang K, Li W, Ying YH, Gao GX, Li XB, Huang HQ. Astragalus Membranaceus prevents airway hyperreactivity in mice related to Th2 response inhibition. J Ethnopharmacol. 2008;116(2):363–9.

    Article  PubMed  Google Scholar 

  84. Zhu H, Zhang Y, Ye G, Li Z, Zhou P, Huang C. In vivo and in vitro antiviral activities of calycosin-7-O-β-D-glucopyranoside against coxsackie virus B3. Biol Pharm Bull. 2009;32(1):68–73.

    Article  PubMed  Google Scholar 

  85. Fu J, Wang Z, Huang L, Zheng S, Wang D, Chen S, Zhang H, Yang S. Review of the botanical characteristics, phytochemistry, and pharmacology of Astragalus membranaceus (Huangqi). Phytother Res. 2014;28(9):1275–83.

    Article  PubMed  Google Scholar 

  86. Auyeung KK, Han QB, Ko JK. Astragalus membranaceus: a review of its protection against inflammation and gastrointestinal cancers. Am J Chin Med. 2016;44(01):1–22.

    Article  PubMed  Google Scholar 

  87. Yin X, Zhang Y, Wu H, Zhu X, Zheng X, Jiang S, Zhuo H, Shen J, Li L, Qiu J. Protective effects of Astragalus saponin I on early stage of diabetic nephropathy in rats. J Pharmacol Sci. 2004;95(2):256–66.

    Article  PubMed  Google Scholar 

  88. Ramalingum N, Mahomoodally MF. The therapeutic potential of medicinal foods. Adv Pharmacol Pharm Sci. 2014;2014:354264.

    Google Scholar 

  89. Bhandari PR. Curry leaf (Murraya koenigii) or cure leaf: review of its curative properties. J Med Nutr Nutraceut. 2012;1(2):92.

    Article  Google Scholar 

  90. Lal M, Kaur N. Effect of processing on nutritional and antinutritional composition of curry leaves (Murraya koenigii). Int J Home Sci. 2019;5(3):186–90.

    Google Scholar 

  91. Saini SC, Reddy GB. A review on curry leaves (Murraya koenigii): versatile multi-potential medicinal plant. Am J Phytomed Clin Ther. 2015;3(04):363–8.

    Google Scholar 

  92. Kaur P, Davar V. Exploring the nutraceutical and therapeutic potential of commonly used Indian spices. Int J Physiol Nutr Phys Educ. 2018;3:410–9.

    Google Scholar 

  93. Paul S, Bandyopadhyay TK, Bhattacharyya A. Immunomodulatory effect of leaf extract of Murraya koenigii in diabetic mice. Immunopharmacol Immunotoxicol. 2011;33(4):691–9.

    Article  PubMed  Google Scholar 

  94. Bhargava K, Singh DK. Aloe vera medical plant. Eur Chem Bull. 2023:1755–64.

    Google Scholar 

  95. Haque MN, Saha BK, Karim MR, Bhuiyan MN. Evaluation of nutritional and physico-chemical properties of several selected fruits in Bangladesh. Bangladesh J Sci Ind Res. 2009;44(3):353–8.

    Article  Google Scholar 

  96. Vijaya Anand A, Velayuthaprabhu S, Rengarajan RL, Sampathkumar P, Radhakrishnan R. Bioactive compounds of guava (Psidium guajava L.). Bioactive compounds in underutilized fruits and nuts 2020:503–527.

    Google Scholar 

  97. Mumtaz S, Ali S, Tahir HM, Kazmi SA, Shakir HA, Mughal TA, Mumtaz S, Summer M, Farooq MA. Aging and its treatment with vitamin C: a comprehensive mechanistic review. Mol Biol Rep. 2021;1:1–3.

    Google Scholar 

  98. Naseer S, Hussain S, Naeem N, Pervaiz M, Rahman M. The phytochemistry and medicinal value of Psidium guajava (guava). Clin Phytosci. 2018;4(1):1–8.

    Article  Google Scholar 

  99. Jiménez-Escrig A, Rincón M, Pulido R, Saura-Calixto F. Guava fruit (Psidium guajava L.) as a new source of antioxidant dietary fiber. J Agric Food Chem. 2001;49(11):5489–93.

    Article  PubMed  Google Scholar 

  100. Laily N, Kusumaningtyas RW, Sukarti I, Rini MRDK. The potency of guava Psidium Guajava (L.) leaves as a functional immunostimulatory ingredient. Procedia Chem. 2015;14:301–7.

    Article  Google Scholar 

  101. Lashgari NA, Momeni Roudsari N, Khayatan D, Shayan M, Momtaz S, Roufogalis BD, Abdolghaffari AH, Sahebkar A. Ginger and its constituents: role in treatment of inflammatory bowel disease. Biofactors. 2022;48(1):7–21.

    Article  PubMed  Google Scholar 

  102. Ahmed RS, Suke SG, Seth V, Chakraborti A, Tripathi AK, Banerjee BD. Protective effects of dietary ginger (Zingiber officinale Rosc.) on lindane-induced oxidative stress in rats. Phytother Res. 2008;22(7):902–6.

    Article  PubMed  Google Scholar 

  103. Al-Hashemi ZSS, Hossain MA. Biological activities of different neem leaf crude extracts used locally in ayurvedic medicine. Pac Sci Rev A Nat Sci Eng. 2016;18(2):128–31.

    Google Scholar 

  104. Patel MJ, Tripathy S, Mukhopadhyay KD, Wangjam T, Cabang AB, Morris J, Wargovich MJ. A supercritical CO2 extract of neem leaf (A. indica) and its bioactive liminoid, nimbolide, suppresses colon cancer in preclinical models by modulating pro-inflammatory pathways. Mol Carcinog. 2018;57(9):1156–65.

    Article  PubMed  Google Scholar 

  105. Sharma SK, Ilavazhagan G, Kumar D, Selvamurthy W. Immunomodulatory effects of NIM-76, a volatile fraction from neem oil. J Ethnopharmacol. 1997;55(2):133–9.

    Article  PubMed  Google Scholar 

  106. Kapoor D, Vijayvergiya R, Dhawan V. Terminalia arjuna in coronary artery disease: ethnopharmacology, pre-clinical, clinical & safety evaluation. J Ethnopharmacol. 2014;155(2):1029–45.

    Article  PubMed  Google Scholar 

  107. Maulik SK, Talwar KK. Therapeutic potential of Terminalia arjuna in cardiovascular disorders. Am J Cardiovasc Drugs. 2012;12:157–63.

    Article  PubMed  Google Scholar 

  108. Gaherwal S, Anare R, Nageshwar W, Prakash MM. Immunomodulatory efficacy of Terminalia arjuna against Aspiculuris tetraptera in mice. Int J Microbiol Res. 2014;5(1):23–9.

    Google Scholar 

  109. Atanasov AG, Waltenberger B, Pferschy-Wenzig EM, Linder T, Wawrosch C, Uhrin P, Temml V, Wang L, Schwaiger S, Heiss EH, Rollinger JM. Discovery and resupply of pharmacologically active plant-derived natural products: A review. Biotechnol Adv. 2015;33(8):1582–614.

    Article  PubMed  PubMed Central  Google Scholar 

  110. Low Z, Lani R, Tiong V, Poh C, AbuBakar S, Hassandarvish P. COVID-19 therapeutic potential of natural products. Int J Mole Sci. 2023;24(11):9589.

    Article  Google Scholar 

  111. Fredrickson BL. The role of positive emotions in positive psychology: the broaden-and-build theory of positive emotions. Am Psychol. 2001;56(3):218.

    Article  PubMed  PubMed Central  Google Scholar 

  112. Wilson DR, Warise L. Cytokines and their role in depression. Perspect Psychiatr Care. 2008;44(4):285–9.

    Article  PubMed  Google Scholar 

  113. Rubio-Perez JM, Morillas-Ruiz JM. A review: inflammatory process in Alzheimer’s disease, role of cytokines. Sci World J. 2012;2012

    Google Scholar 

  114. Mansur RB, Zugman A, Asevedo ED, da Cunha GR, Bressan RA, Brietzke E. Cytokines in schizophrenia: possible role of anti-inflammatory medications in clinical and preclinical stages. Psychiatry Clin Neurosci. 2012;66(4):247–60.

    Article  PubMed  Google Scholar 

  115. Arrieta MC, Finlay BB. The commensal microbiota drives immune homeostasis. Front Immunol. 2012;3:33.

    Article  PubMed  PubMed Central  Google Scholar 

  116. Li M, Wang B, Zhang M, Rantalainen M, Wang S, Zhou H, Zhang Y, Shen J, Pang X, Zhang M, Wei H. Symbiotic gut microbes modulate human metabolic phenotypes. Proc Natl Acad Sci. 2008;105(6):2117–22.

    Article  PubMed  PubMed Central  Google Scholar 

  117. Sun S, Wang Y, Wu A, Ding Z, Liu X. Influence factors of the pharmacokinetics of herbal resourced compounds in clinical practice. Evid Based Complement Alternat Med. 2019;2019

    Google Scholar 

  118. Vlasova AN, Kandasamy S, Chattha KS, Rajashekara G, Saif LJ. Comparison of probiotic lactobacilli and bifidobacteria effects, immune responses and rotavirus vaccines and infection in different host species. Vet Immunol Immunopathol. 2016;172:72–84.

    Article  PubMed  PubMed Central  Google Scholar 

  119. Ruiz L, Delgado S, Ruas-Madiedo P, Sánchez B, Margolles A. Bifidobacteria and their molecular communication with the immune system. Front Microbiol. 2017;8:2345.

    Article  PubMed  PubMed Central  Google Scholar 

  120. Peterson CT, Sharma V, Uchitel S, Denniston K, Chopra D, Mills PJ, Peterson SN. Prebiotic potential of herbal medicines used in digestive health and disease. J Altern Complement Med. 2018;24(7):656–65.

    Article  PubMed  PubMed Central  Google Scholar 

  121. Koboziev I, Karlsson F, Grisham MB. Gut-associated lymphoid tissue, T cell trafficking, and chronic intestinal inflammation. Ann N Y Acad Sci. 2010;1207:86–93.

    Article  Google Scholar 

  122. Classen B, Thude S, Blaschek W, Wack M, Bodinet C. Immunomodulatory effects of arabinogalactan-proteins from Baptisia and Echinacea. Phytomedicine. 2006;13(9–10):688–94.

    Article  PubMed  Google Scholar 

  123. Batbayar S, Lee DH, Kim HW. Immunomodulation of fungal β-glucan in host defense signaling by dectin-1. Biomol Ther. 2012;20(5):433.

    Article  Google Scholar 

  124. Li ZX, Zhao GD, Xiong W, Linghu KG, Ma QS, Cheang WS, Yu H, Wang Y. Immunomodulatory effects of a new whole ingredients extract from Astragalus: a combined evaluation on chemistry and pharmacology. Chin Med. 2019;14:1–10.

    Article  Google Scholar 

  125. Du X, Zhao B, Li J, Cao X, Diao M, Feng H, Chen X, Chen Z, Zeng X. Astragalus polysaccharides enhance immune responses of HBV DNA vaccination via promoting the dendritic cell maturation and suppressing Treg frequency in mice. Int Immunopharmacol. 2012;14(4):463–70.

    Article  PubMed  Google Scholar 

  126. Phetkate P, Kummalue T, Kietinun S. Significant increase in cytotoxic T lymphocytes and natural killer cells by triphala: A clinical phase I study. Evid Based Complement Alternat Med 2012;2012.

    Google Scholar 

  127. Tyler VE. Phytomedicines: back to the future. J Nat Prod. 1999;62(11):1589–92.

    Article  PubMed  Google Scholar 

  128. Rathore D, Srivastava R, Geetanjali SR. Phytochemical screening, antioxidant and antimicrobial activities of Bombax ceiba flower. Alger J Nat Prod. 2019;7(1):651–6.

    Google Scholar 

  129. Rathore D, Srivastava R, Geetanjali SR. Phytochemistry and pharmacology of genus Bombax. Nat Prod J. 2019;9(3):184–96.

    Google Scholar 

  130. Singh R, Geetanjali. Asparagus racemosus: a review on its phytochemical and therapeutic potential. Nat Prod Res. 2016;30(17):1896–908.

    Article  PubMed  Google Scholar 

  131. Gasmi A, Mujawdiya PK, Lysiuk R, Shanaida M, Peana M, Gasmi Benahmed A, Beley N, Kovalska N, Bjorklund G. Quercetin in the prevention and treatment of coronavirus infections: a focus on SARS-CoV-2. Pharmaceuticals. 2022;15:1049.

    Article  PubMed  PubMed Central  Google Scholar 

  132. Javadi F, Ahmadzadeh A, Eghtesadi S, Aryaeian N, Zabihiyeganeh M, Rahimi Foroushani A, Jazayeri S. The effect of quercetin on inflammatory factors and clinical symptoms in women with rheumatoid arthritis: a double-blind, randomized controlled trial. J Am Coll Nutr. 2017;36:9–15.

    Article  PubMed  Google Scholar 

  133. Akramiene D, Kondrotas A, Didziapetriene J, Kevelaitis E. Effects of beta-glucans on the immune system. Medicina. 2007;43:597–606.

    Article  PubMed  Google Scholar 

  134. Farnoosh G, Akbariqomi M, Badri T, Bagheri M, Izadi M, Saeedi-Boroujeni A, Rezaei E, Ghaleh H, Aghamollaei H, Fasihi-Ramandi M, et al. Efficacy of a low dose of melatonin as an adjunctive therapy in hospitalized patients with COVID-19: a randomized, double-blind clinical trial. Arch Med Res. 2020;53:79–85.

    Article  Google Scholar 

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Acknowledgments

The authors Anchal Dabas, Parul Yadav, and Ram Singh are thankful to DTU, and Geetanjali to Kirori Mal College for infrastructural support.

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Authors and Affiliations

  1. Department of Applied Chemistry, Delhi Technological University, Delhi, India

    Anchal Dabas, Parul Yadav & Ram Singh

  2. Department of Chemistry, Kirori Mal College, University of Delhi, Delhi, India

    Geetanjali

Authors
  1. Anchal Dabas
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  2. Parul Yadav
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  3. Geetanjali
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  4. Ram Singh
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Correspondence to Ram Singh .

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Editors and Affiliations

  1. Department of Pharmacy, Contai Polytechnic, Government of West Bengal, Kolkatta, West Bengal, India

    Amal Kumar Dhara

  2. Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India

    Subhash C. Mandal

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Dabas, A., Yadav, P., Geetanjali, Singh, R. (2023). Role of Herbal Medicine in Boosting Immune System. In: Dhara, A.K., Mandal, S.C. (eds) Role of Herbal Medicines . Springer, Singapore. https://doi.org/10.1007/978-981-99-7703-1_19

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