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Mitochondrial dysregulation and protection in cisplatin nephrotoxicity

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Abstract

Nephrotoxicity is a major side effect of cisplatin in chemotherapy. Pathologically, cisplatin nephrotoxicity is characterized by cell injury and death in renal tubules. The research in the past decade has gained significant understanding of the cellular and molecular mechanisms of tubular cell death, revealing a central role of mitochondrial dysregulation. The pathological changes in mitochondria in cisplatin nephrotoxicity are mainly triggered by DNA damage response, pro-apoptotic protein attack, disruption of mitochondrial dynamics, and oxidative stress. As such, inhibitory strategies targeting these cytotoxic events may provide renal protection. Nonetheless, ideal approaches for renoprotection should not only protect kidneys but also enhance the anticancer efficacy of cisplatin in chemotherapy.

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Acknowledgments

This study was sponsored by National Natural Science Foundation of China (81370791), the key project of the Hunan Province Natural Science Foundation, China (No. 2009TP-1066-2), and the National Institutes of Health and Department of Veterans Administration of USA.

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Authors and Affiliations

  1. Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China

    Yuan Yang, Hong Liu, Fuyou Liu & Zheng Dong

  2. Department of Cellular Biology and Anatomy, Medical College of Georgia at Georgia Regents University, 1459 Laney Walker Blvd, Augusta, GA, 30912, USA

    Zheng Dong

  3. Department of Cellular Biology and Anatomy, Charlie Norwood VA Medical Center, Augusta, GA, USA

    Zheng Dong

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  1. Yuan Yang
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  2. Hong Liu
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  3. Fuyou Liu
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Correspondence to Zheng Dong.

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Yang, Y., Liu, H., Liu, F. et al. Mitochondrial dysregulation and protection in cisplatin nephrotoxicity. Arch Toxicol 88, 1249–1256 (2014). https://doi.org/10.1007/s00204-014-1239-1

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