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Phytoconstituents for Boosting the Stem Cells Used in Regenerative Medicine

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Abstract

Purpose of Review

Stem cells are the group of undifferentiated or partially differentiated cells which have the potential to distinguish in various forms of cells. These cells are found in both embryonic and adult stages, but their properties are slightly different in their functions. Tissue regeneration and homeostasis are dependent on the activity and viability of adult stem cells. Stem cells respond to the dietary signals. So phytochemicals and vitamins, having antioxidant, chemo preventive, and anti-inflammatory properties, can alter the functions and renewal activities of stem cells. In this review, we have focused on how different phytochemicals and vitamins can change the microenvironment of different stem cells to control their activities.

Recent Findings

Recent findings have reported that phenols, flavonoids, sterols, alkaloids, etc., including different vitamins, are critical for stem cell growth and regeneration. These biomolecules can stimulate major signalling pathways and key transcription factors to regulate self-renewal and differentiation of stem cell sub-populations.

Summary

In this review, we have summarised different stem cell types with their diet-induced signals responding to specific plant metabolites. It has also been discussed about the possibility to target the biomolecules for therapeutic dietary interventions or mimetics for stem cell regeneration physiology.

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Data Availability

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Funding

The authors gratefully acknowledge the University Grants Commission, New Delhi, and the University Of Kalyani for supporting this research.

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Authors and Affiliations

  1. Department of Zoology, University of Kalyani, Kalyani, Nadia, West Bengal, Pin 741235, India

    Debjani Nath, Baishakhi Bairagi & Farhin Khan

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  1. Debjani Nath
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DN conceptualized the title and BB and FK wrote the manuscript text. FK prepared figures and table and all authors reviewed the manuscript.

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Correspondence to Debjani Nath.

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Nath, D., Bairagi, B. & Khan, F. Phytoconstituents for Boosting the Stem Cells Used in Regenerative Medicine. Curr Pharmacol Rep 9, 228–246 (2023). https://doi.org/10.1007/s40495-023-00322-2

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