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Combinational Therapy Using Chemotherapeutic Agents and Dietary Bioactive Compounds: A Pragmatic Approach to Cancer Treatment

Combinational Therapy Using Chemotherapeutic Agents and Dietary Bioactive Compounds: A Pragmatic Approach to Cancer Treatment

Madhumitha Kedhari Sundaram, Shefina Silas, Arif Hussain
Copyright: © 2021 |Pages: 27
ISBN13: 9781799848080|ISBN10: 1799848086|EISBN13: 9781799848097
DOI: 10.4018/978-1-7998-4808-0.ch008
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MLA

Kedhari Sundaram, Madhumitha, et al. "Combinational Therapy Using Chemotherapeutic Agents and Dietary Bioactive Compounds: A Pragmatic Approach to Cancer Treatment." Treating Endocrine and Metabolic Disorders With Herbal Medicines, edited by Arif Hussain and Shalini Behl, IGI Global, 2021, pp. 188-214. https://doi.org/10.4018/978-1-7998-4808-0.ch008

APA

Kedhari Sundaram, M., Silas, S., & Hussain, A. (2021). Combinational Therapy Using Chemotherapeutic Agents and Dietary Bioactive Compounds: A Pragmatic Approach to Cancer Treatment. In A. Hussain & S. Behl (Eds.), Treating Endocrine and Metabolic Disorders With Herbal Medicines (pp. 188-214). IGI Global. https://doi.org/10.4018/978-1-7998-4808-0.ch008

Chicago

Kedhari Sundaram, Madhumitha, Shefina Silas, and Arif Hussain. "Combinational Therapy Using Chemotherapeutic Agents and Dietary Bioactive Compounds: A Pragmatic Approach to Cancer Treatment." In Treating Endocrine and Metabolic Disorders With Herbal Medicines, edited by Arif Hussain and Shalini Behl, 188-214. Hershey, PA: IGI Global, 2021. https://doi.org/10.4018/978-1-7998-4808-0.ch008

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Abstract

Diet-derived phytochemicals find prominent use in traditional medicine and have been credited with lowering cancer risk significantly. Dietary agents demonstrate anticancer activity by modulating various molecular targets and cell signaling pathways. Several studies have focused on combinations of dietary bioactive compounds and conventional chemotherapeutic agents to augment their therapeutic response and mitigate the side effects of conventional chemotherapy. The observed synergistic response heralds promise for successful future chemopreventive and chemotherapeutic strategies in cancer management. Animal models and pre-clinical trials of the effective combinations must be undertaken to clearly understand the mechanism of action. This chapter catalogues recent studies that have used dietary bioactive compounds (sulforaphane, EGCG, curcumin, genistein, resveratrol, eugenol) in combination with conventional chemopreventive agents and with other phytochemicals.

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