Abstract
Selenium (Se) is an essential nutritional factor that was shown by us to alter the expression of the high affinity interleukin 2 receptor (Il 2-R) and its subunits, cell proliferation, and clonal expansion of cytotoxic T-lymphocytes in mice. This study shows that dietary supplementation of Se-replete humans with 200 μg/d of sodium selenite for 8 wk, or in vitro supplementation with 1×10−7 M Se (as sodium selenite), result in a significant augmentation of the ability of peripheral blood lymphocytes to respond to stimulation with 1 μg/mL of phytohemagglutinin or alloantigen (mixed lymphocyte reaction) and to express high affinity Il 2-R on their surface. There was a clear correlation between supplementation with Se and enhanced3H-thymidine incorporation into nuclear DNA, preceded by enhanced expression of high affinity Il 2-R. Supplementation with Se can apparently modulate T-lymphocyte mediated immune responses in humans that depend on signals generated by the interaction of interleukin 2 with Il 2-R.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
D.A. Cantrell and K.A. Smith,Science 224, 1312–1316 (1984).
K.A. Smith,Science 240, 1169–1176 (1988).
M. Roy, L. Kiremidjian-Schumacher, H.I. Wishe, M.W. Cohen and G. Stotzky,Proc. Soc. Exp. Biol. Med. 200, 36–43 (1992).
M. Roy, L. Kiremidjian-Schumacher, H.I. Wishe, M.W. Cohen, and G. Stotzky,Proc. Soc. Exp. Biol. Med. 202, 295–301 (1993).
L. Kiremidjian-Schumacher, M. Roy, H.I. Wishe, M.W. Cohen, and G. Stotzky,Proc. Soc. Exp. Biol. Med. 193, 136–142 (1990).
M. Roy, L. Kiremidjian-Schumacher, H.I. Wishe, M.W. Cohen, and G. Stotzky,Proc. Soc. Exp. Biol. Med. 193, 143–148 (1990).
L. Kiremidjian-Schumacher, M. Roy, H.I. Wishe, M.W. Cohen, and G. Stotzky,Biol. Trace Elem. Res. 33, 23–35 (1992).
L. Kiremidjian-Schumacher, M. Roy, H.I. Wishe, M.W. Cohen, and G. Stotzky,J. Nutr. Immunol. 1, 65–67 (1992).
J.E. Spallholz, G.F. Collins, and K.A. Schwartz,Bioinorg. Chem. 9, 453–459 (1978).
R.J. Robb, P.C. Mayer, and R. Garlick,J. Immunol. Meth. 81, 15–30 (1985).
P.D. Brown and F.V. Sepulveda,J. Physiol. 363, 257–270 (1985).
G.N. Schrauzer and D.A. White,Bioinorg. Chem. 8, 303–318 (1978).
L. Olmsted, G.N. Schrauzer, M. Floses-Arce, and J. Dowd,Biol. Trace Elem. Res. 20, 59–65, (1989).
H.M. Meltzer, G. Norheim, E.G. Loken, and H. Holm,Br. J. Nutr. 67, 287–294 (1992).
H.M. Meltzer, G. Norheim, K. Bibow, K. Myhre, and H. Holm,Eur. J. Clin. Nutr. 44, 435–446 (1990).
P.V. Nash and A.M. Mastro,J. Leuk. Biol. 53, 73–78 (1993).
T. Takeshita, H. Asao, K. Ohtari, N. Ishii, S. Kumaki, N. Tanaka, H. Manakata, M. Nakamura and K. Sugamura,Science 257, 379–382 (1992).
W.A. Kuziel, G. Ju, T.A. Grdina, and W.C. Greene,J. Immunol. 150, 3357–3365 (1993).
M. Hatakeyama, S. Minamoto, T. Uchiyama, R.R. Hardy, G. Yamada, and T. Taniguchi,Nature 318 467–470 (1985).
W.C. Greene, R.J. Robb, P.B. Svetlik, G.M. Rusk, J.M. Depper, and W.J. Leonard,J. Exp. Med. 162, 363–368 (1985).
Y. Minami, T. Kono, T. Miyazaki, and T. Taniguchi,Annu. Rev. Immunol. 11, 245–267 (1993).
L. Kiremidjian-Schumacher, M. Roy, H.I. Wishe, M.W. Cohen, and G. Stotzky,Biol. Trace Elem. Res. this issue (1994).
K.S. Ullman, J.P. Northrop, C.L. Verweij, and G.R. Crabtree,Annu. Rev. Immunol. 8, 421–452 (1990).
Author information
Authors and Affiliations
Additional information
An erratum to this article is available at http://dx.doi.org/10.1007/BF02790078.
Rights and permissions
About this article
Cite this article
Roy, M., Kiremidjian-Schumacher, L., Wishe, H.I. et al. Supplementation with selenium and human immune cell functions. Biol Trace Elem Res 41, 103–114 (1994). https://doi.org/10.1007/BF02917221
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02917221