Type 1 Interferons and the Virus-Host Relationship: A Lesson in Détente
Abstract
The interface between an infectious agent and its host represents the ultimate battleground for survival: The microbe must secure a niche for replication, whereas the host must limit the pathogen's advance. Among the host's arsenal of antimicrobial factors, the type 1 interferons (IFNs) induce potent defense mechanisms against viruses and are key in the host-virus standoff. Viruses have evolved multiple tricks to avoid the immediate antiviral effects of IFNs and, in turn, hosts have adapted use of this innate cytokine system to galvanize multiple additional layers of immune defense. The plasticity that exists in these interactions provides us with a lesson in détente.
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Work in A.G.-S.'s lab is supported by NIH grants R01AI46954, P01AI52106, P01AI58113, U54AI57158, and U19AI62623, and DOD grant W81XWH-04-1-0876. Work in C.A.B.'s lab is supported by NIH grants RO1CA41268 and RO1AI55677. In memory of Theresa P. Biron.
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Published In
Science
Volume 312 | Issue 5775
12 May 2006
12 May 2006
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American Association for the Advancement of Science.
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Published in print: 12 May 2006
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- Adolfo García-Sastre,
- Christine A. Biron
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What's Its Name?
*What's its name?
NF-kB can widely inflame
but it can not take the blame
for a neural error
that caused a furor
when nuclear was dropped from its name.
*We note that a recent article—"Type 1 interferons and the virus-host relationship: a lesson in détente" by A. Garcia-Sastre and C. A. Biron, Review, Science 312 (5775) 879-882 (2006)—inadvertently transformed the proper name of nuclear factor-kB to neural factor-kB.