Childhood undernutrition, the gut microbiota, and microbiota-directed therapeutics
Gut microbiota and undernutrition
Structured Abstract
BACKGROUND
ADVANCES
OUTLOOK
Abstract
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24 June 2016
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- Laura V. Blanton et al.
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- Gut Microbiota and Cardiovascular System: An Intricate Balance of Health and the Diseased State, Life, 12, 12, (1986), (2022).https://doi.org/10.3390/life12121986
- Nutritional status and function after high-calorie formula vs. Chinese food intervention in undernourished children with cerebral palsy, Frontiers in Nutrition, 9, (2022).https://doi.org/10.3389/fnut.2022.960763
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- Intestinal Inflammation is Significantly Associated With Length Faltering in Preterm Infants at Neonatal Intensive Care Unit Discharge, Journal of Pediatric Gastroenterology & Nutrition, 74, 6, (837-844), (2022).https://doi.org/10.1097/MPG.0000000000003455
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RE: Undernutrition and the gut microbiota
Natural consolidation of a robust microbiota is a longstanding and complex process resulting in an highly diversified and resilient microbial community. In sharp contrast, significant perturbations of these optimally functioning ecological niches may result from acute and aggressive factors such as the administration of a very short course of antibiotics. Repair of a perturbed microbiota is almost always an unreachable goal, as demonstrated by frequent failure of probiotics in a myriad of clinical situations. We believe that a deep understanding of the intimate mechanisms of the perturbation microbiota in childhood undernutrition may help in the prevention of this horrible and ubiquitous problem rather than in its cure once it has been developed.